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Tbio
SPRY3
Protein sprouty homolog 3

Protein Summary
Description
May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302805
  • ENSP00000302978
  • ENSG00000168939

Symbol
  • spry-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.65
microRNA
0.65
tissue sample
0.56
cell type or tissue
0.54
cell line
0.49


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.98   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 94   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.98   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 94   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
1
1
2
75
body mass index
1
1
1
72.3
low density lipoprotein cholesterol measurement
1
1
2
71.3
triglyceride measurement
1
1
2
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
2
75
body mass index
1
72.3
low density lipoprotein cholesterol measurement
2
71.3
triglyceride measurement
2
54.4
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1345188
236576
Rat
RGD:1562172
498159
Horse
sprouty RTK signaling antagonist 3
VGNC:23545
100062480
Cow
sprouty RTK signaling antagonist 3
VGNC:35243
539402
Chicken
sprouty RTK signaling antagonist 3
CGNC:5620
428712
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
sprouty RTK signaling antagonist 3
Cow
sprouty RTK signaling antagonist 3
Chicken
sprouty RTK signaling antagonist 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O43610-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
EGF receptor signaling pathway
PathwayCommons: panther
FGF signaling pathway
PathwayCommons: netpath
EGFR1
Name
Explore in Pharos
Explore in Source
EGF receptor signaling pathway
FGF signaling pathway
EGFR1
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (29)
1 – 10 of 29
CBL
Tbio
Family:  Enzyme
Novelty:  0.00114929
Score:  0.938
Data Source:  STRINGDB
SPRY1
Tbio
Novelty:  0.00441927
Score:  0.93
Data Source:  STRINGDB
SPRY4
Tbio
Novelty:  0.01578378
Score:  0.928
Data Source:  STRINGDB
SPRY2
Tbio
Novelty:  0.00884945
Score:  0.927
Data Source:  STRINGDB
RASA1
Tbio
Family:  Enzyme
Novelty:  0.00425286
Score:  0.92
Data Source:  STRINGDB
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
Score:  0.919
Data Source:  STRINGDB
PTPRB
Tchem
Family:  Enzyme
Novelty:  0.00797419
Score:  0.917
Data Source:  STRINGDB
VAMP7
Tbio
Novelty:  0.00900603
Score:  0.777
Data Source:  STRINGDB
SPARC
Tbio
Novelty:  0.00063267
Score:  0.71
Data Source:  STRINGDB
RENBP
Tbio
Family:  Enzyme
Novelty:  0.02220005
Score:  0.704
Data Source:  STRINGDB
Publication Statistics
PubMed Score  11.98

PubMed score by year
PubTator Score  3.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer