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Tbio
SPRY1
Protein sprouty homolog 1

Protein Summary
Description
May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339241
  • ENSP00000343785
  • ENSG00000164056
  • ENST00000394339
  • ENSP00000377871
  • ENST00000610581
  • ENSP00000481675
  • ENST00000622283
  • ENSP00000480540

Symbol
  • hSPRY1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.88
virus perturbation
0.88
biological process
0.86
disease perturbation
0.79
small molecule perturbation
0.73


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 209.69   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 255   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 209.69   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 255   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
sprouty RTK signaling antagonist 1
708752
Mouse
MGI:1345139
24063
Rat
RGD:1309293
294981
Dog
sprouty RTK signaling antagonist 1
VGNC:54828
483838
Horse
sprouty RTK signaling antagonist 1
VGNC:23543
100063739
Species
Name
OMA
EggNOG
Inparanoid
Macaque
sprouty RTK signaling antagonist 1
Mouse
Rat
Dog
sprouty RTK signaling antagonist 1
Horse
sprouty RTK signaling antagonist 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O43609-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
EGFR downregulation (R-HSA-182971)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
EGFR downregulation
Reactome
Signal Transduction
Reactome
Signaling by EGFR
Reactome
Signaling by Receptor Tyrosine Kinases
Name
Explore in Pharos
Explore in Source
EGFR downregulation
Signal Transduction
Signaling by EGFR
Signaling by Receptor Tyrosine Kinases
Gene Ontology Terms (18)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (109)
1 – 10 of 109
CBL
Tbio
Family: Enzyme
Novelty: 0.00114929
Score: 0.975
Data Source: Reactome,STRINGDB
EGFR
Tclin
Family: Kinase
Novelty: 0.00007274
Score: 0.951
Data Source: Reactome,STRINGDB
SH3KBP1
Tbio
Family: Enzyme
Novelty: 0.01454593
Score: 0.949
Data Source: STRINGDB
RASA1
Tbio
Family: Enzyme
Novelty: 0.00425286
Score: 0.947
Data Source: STRINGDB
EGF
Tbio
Novelty: 0.00010809
Score: 0.945
Data Source: STRINGDB
SPRY2
Tbio
Novelty: 0.00884945
Score: 0.943
Data Source: STRINGDB
HRAS
Tchem
Family: Enzyme
Novelty: 0.00008069
Score: 0.94
Data Source: STRINGDB
SPRY4
Tbio
Novelty: 0.01578378
Score: 0.932
Data Source: STRINGDB
SPRY3
Tbio
Novelty: 0.06114906
Score: 0.93
Data Source: STRINGDB
HGS
Tbio
Family: Enzyme
Novelty: 0.00665044
Score: 0.913
Data Source: STRINGDB
Publication Statistics
PubMed Score  209.69

PubMed score by year
PubTator Score  37.61

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer