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Tbio
SPRY1
Protein sprouty homolog 1

Protein Summary
Description
May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339241
  • ENSP00000343785
  • ENSG00000164056
  • ENST00000394339
  • ENSP00000377871
  • ENST00000610581
  • ENSP00000481675
  • ENST00000622283
  • ENSP00000480540

Symbol
  • hSPRY1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.88
virus perturbation
0.88
biological process
0.86
disease perturbation
0.79
small molecule perturbation
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 176.38   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 255   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 176.38   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 255   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (10)
EGFR downregulation (R-HSA-182971)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
EGFR downregulation
Reactome
Signal Transduction
Reactome
Signaling by EGFR
Reactome
Signaling by Receptor Tyrosine Kinases
Name
Explore in Pharos
Explore in Source
EGFR downregulation
Signal Transduction
Signaling by EGFR
Signaling by Receptor Tyrosine Kinases
Gene Ontology Terms (18)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (109)
1 – 10 of 109
CBL
Tbio
Family: Enzyme
Novelty: 0.00118988
Score: 0.975
Data Source: Reactome,STRINGDB
EGFR
Tclin
Family: Kinase
Novelty: 0.0000974
Score: 0.951
Data Source: Reactome,STRINGDB
SH3KBP1
Tbio
Family: Enzyme
Novelty: 0.01467085
Score: 0.949
Data Source: STRINGDB
RASA1
Tbio
Family: Enzyme
Novelty: 0.00312451
Score: 0.947
Data Source: STRINGDB
EGF
Tbio
Novelty: 0.00015623
Score: 0.945
Data Source: STRINGDB
SPRY2
Tbio
Novelty: 0.01058901
Score: 0.943
Data Source: STRINGDB
HRAS
Tchem
Family: Enzyme
Novelty: 0.00008788
Score: 0.94
Data Source: STRINGDB
SPRY4
Tbio
Novelty: 0.01980762
Score: 0.932
Data Source: STRINGDB
SPRY3
Tbio
Novelty: 0.10243032
Score: 0.93
Data Source: STRINGDB
HGS
Tbio
Family: Enzyme
Novelty: 0.00097717
Score: 0.913
Data Source: STRINGDB
Publication Statistics
PubMed Score  176.38

PubMed score by year
PubTator Score  37.61

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer