Tchem GALR2 Galanin receptor type 2

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Galanin Receptor Type 2

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Galanin Receptor / Galanin Receptor Type 2

Protein Summary

Description

Receptor for the hormone galanin and GALP. Receptor for the hormone spexin-1 (PubMed:24517231). The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)). Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O43603
• A5JUU4
• Q32MN8
• GAL2-R

Gene Name

• GALR2

Ensembl ID

• ENST00000329003
• ENSP00000329684
• ENSG00000182687

Symbol

• GALNR2
• GAL2-R
• GALNR2
• GALR-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (chemical)	1
biological process	0.92
gene perturbation	0.71
PubMedID	0.65
molecular function	0.63

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.92   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 255   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.92   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 255   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 30

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (30)

Explore Active Ligands

1 – 10 of 30

CHEMBL507373

GALR2Tchem GPCR

Ki : 7.12

CHEMBL1790054

GALR2Tchem GPCR

Ki : 7.18

CHEMBL578514

GALR2Tchem GPCR

Ki : 7.29

CHEMBL504758

GALR2Tchem GPCR

Ki : 7.29

CHEMBL525023

GALR2Tchem GPCR

Ki : 7.29

CHEMBL507353

GALR2Tchem GPCR

Ki : 7.29

CHEMBL578910

GALR2Tchem GPCR

Ki : 7.46

CHEMBL504914

GALR2Tchem GPCR

Ki : 7.55

CHEMBL508036

GALR2Tchem GPCR

Ki : 7.62

CHEMBL499807

GALR2Tchem GPCR

Ki : 7.76

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	galanin receptor 2	VGNC:9291	468332
Mouse	galanin receptor 2	MGI:1337018	14428
Rat	galanin receptor 2 [Source:RGD Symbol;Acc:2657]
Dog	galanin receptor 2	VGNC:41101	483325
Horse	galanin receptor 2	VGNC:18237	100051251

Species	Name	OMA	EggNOG	Inparanoid
Chimp	galanin receptor 2
Mouse	galanin receptor 2
Rat	galanin receptor 2 [Source:RGD Symbol;Acc:2657]
Dog	galanin receptor 2
Horse	galanin receptor 2

Protein Structure (0 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-O43603-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)

Reactome (7)

KEGG (1)

WikiPathways (2)

Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Items per page:

5

1 – 5 of 7

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
Reactome	G alpha (i) signalling events	408 targets	R-HSA-418594
Reactome	GPCR downstream signalling	1152 targets	R-HSA-388396
Reactome	GPCR ligand binding	460 targets	R-HSA-500792
Reactome	Peptide ligand-binding receptors	189 targets	R-HSA-375276

Name	Explore in Pharos	Explore in Source
Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
G alpha (i) signalling events	408 targets	R-HSA-418594
GPCR downstream signalling	1152 targets	R-HSA-388396
GPCR ligand binding	460 targets	R-HSA-500792
Peptide ligand-binding receptors	189 targets	R-HSA-375276

Gene Ontology Terms (25)

Functions (4)

Components (3)

Processes (18)

Find Similar Targets

Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
galanin receptor activity	Inferred from Direct Assay (IDA)	UniProtKB
peptide hormone binding	Inferred from Direct Assay (IDA)	UniProtKB
G protein-coupled peptide receptor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
neuropeptide binding	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (248)

Explore Interacting Targets

1 – 10 of 248

• See Interactions on String-DB

GAL

Tbio

Novelty: 0.0005132

Score: 0.998

Data Source: Reactome,STRINGDB

NPY

Tbio

Novelty: 0.00012637

Score: 0.972

Data Source: STRINGDB

NPY1R

Tchem

Family: GPCR

Novelty: 0.00438376

Score: 0.954

Data Source: STRINGDB

SST

Tbio

Novelty: 0.00005944

Score: 0.945

Data Source: STRINGDB

POMC

Tbio

Novelty: 0.00002436

Score: 0.926

Data Source: STRINGDB

NPY4R

Tchem

Family: GPCR

Novelty: 0.11465741

Score: 0.926

Data Source: STRINGDB

PNOC

Tbio

Novelty: 0.00132014

Score: 0.926

Data Source: STRINGDB

GNAT3

Tbio

Novelty: 0.00702357

Score: 0.925

Data Source: STRINGDB

NPW

Tbio

Novelty: 0.03174263

Score: 0.923

Data Source: STRINGDB

PDYN

Tbio

Novelty: 0.00039564

Score: 0.919

Data Source: STRINGDB

Publication Statistics

PubMed Score  97.92

PubMed score by year

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PubTator Score  57.33

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Receptor
Reference proteome
Transducer
Transmembrane

MGI Phenotype Find Similar Targets

behavior/neurological phenotype
hematopoietic system phenotype
immune system phenotype
integument phenotype
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