Tchem GALR2 Galanin receptor type 2

Protein Summary

Description

Receptor for the hormone galanin and GALP. Receptor for the hormone spexin-1 (PubMed:24517231). The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)). Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O43603
• A5JUU4
• Q32MN8
• GAL2-R

Gene Name

• GALR2

Ensembl ID

• ENST00000329003
• ENSP00000329684
• ENSG00000182687

Symbol

• GALNR2
• GAL2-R
• GALNR2
• GALR-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (chemical)	1
biological process	0.92
gene perturbation	0.71
PubMedID	0.65
molecular function	0.63

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Galanin Receptor Type 2

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Galanin Receptor / Galanin Receptor Type 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.08   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 255   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.08   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 255   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 30

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0