You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
DCX
Neuronal migration protein doublecortin

Protein Summary
Description
Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration. This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded prote ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358070
  • ENSP00000350776
  • ENSG00000077279
  • ENST00000371993
  • ENSP00000361061
  • ENST00000488120
  • ENSP00000419861
  • ENST00000496551
  • ENSP00000490448
  • ENST00000635795
  • ENSP00000489635

Symbol
  • DBCN
  • LISX
  • DC
  • DBCN
  • LISX
  • SCLH
  • XLIS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase
0.97
hub protein
0.79
molecular function
0.76
transcription factor perturbation
0.68
biological term
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1068.59   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 657   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1068.59   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 657   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (131)
NMNAT3
Tbio
Family:  Enzyme
Novelty:  0.03261313
p_int:  0.999995348
p_ni:  2.45e-7
p_wrong:  0.000004408
Score:  0.543
Data Source:  BioPlex,STRINGDB
DCLK1
Tchem
Family:  Kinase
Novelty:  0.0064994
p_int:  0.999989667
p_ni:  1e-9
p_wrong:  0.000010332
Score:  0.884
Data Source:  BioPlex,STRINGDB
DIS3
Tbio
Family:  Enzyme
Novelty:  0.00961238
p_int:  0.999268835
p_ni:  0.000731165
Score:  0.211
Data Source:  BioPlex,STRINGDB
NUFIP1
Tbio
Novelty:  0.11726869
p_int:  0.994650398
p_ni:  0.005349599
p_wrong:  4e-9
Data Source:  BioPlex
DGUOK
Tbio
Family:  Kinase
Novelty:  0.00897987
p_int:  0.99406121
p_ni:  0.005938789
p_wrong:  1e-9
Data Source:  BioPlex
HAX1
Tbio
Novelty:  0.00749205
p_int:  0.994005006
p_ni:  0.005994988
p_wrong:  6e-9
Score:  0.189
Data Source:  BioPlex,STRINGDB
NDUFA10
Tclin
Family:  Enzyme
Novelty:  0.06260343
p_int:  0.983344425
p_ni:  0.016655574
p_wrong:  1e-9
Data Source:  BioPlex
LGALS9C
Tdark
Novelty:  0.29969898
p_int:  0.97509093
p_ni:  0.024909054
p_wrong:  1.6e-8
Data Source:  BioPlex
RGL4
Tdark
Novelty:  0.29339149
p_int:  0.972499343
p_ni:  0.027498235
p_wrong:  0.000002422
Score:  0.359
Data Source:  BioPlex,STRINGDB
DPF3
Tbio
Family:  Epigenetic
Novelty:  0.069151
p_int:  0.970168712
p_ni:  0.02983126
p_wrong:  2.7e-8
Score:  0.194
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
L1CAM interactions
Reactome
Neurofascin interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
L1CAM interactions
Neurofascin interactions
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
doublecortin
706556
Mouse
MGI:1277171
13193
Rat
RGD:620670
84394
Dog
doublecortin
VGNC:54132
612950
Horse
doublecortin
100058909
Species
Name
OMA
EggNOG
Inparanoid
Macaque
doublecortin
Mouse
Rat
Dog
doublecortin
Horse
doublecortin
Publication Statistics
PubMed Score 1068.59
PubMed score by year
PubTator Score 346.45
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title