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Tchem
DNPH1
2'-deoxynucleoside 5'-phosphate N-hydrolase 1

Protein Summary
Description
Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases. This gene was identified on the basis of its stimulation by c-Myc protein. The latter is a transcription factor that participates in the regulation of cell proliferation, differentiation, and apoptosis. The exact function of this gene is not known but studies in rat suggest a role in cellular proliferation and c-Myc-mediated transformation. Two alternative transcripts encoding different proteins have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000230431
  • ENSP00000230431
  • ENSG00000112667
  • ENST00000393987
  • ENSP00000377556

Symbol
  • C6orf108
  • RCL
  • RCL
  • C6orf108
  • dJ330M21.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.84
transcription factor perturbation
0.8
PubMedID
0.7
tissue sample
0.61
tissue
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.19   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 177   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.19   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
1
1
1
1.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
1
1.5
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
2'-deoxynucleoside 5'-phosphate N-hydrolase 1
699111
Cow
2'-deoxynucleoside 5'-phosphate N-hydrolase 1
VGNC:28149
613560
Pig
2'-deoxynucleoside 5'-phosphate N-hydrolase 1
100157902
Opossum
2'-deoxynucleoside 5'-phosphate N-hydrolase 1
100011197
Species
Name
OMA
EggNOG
Inparanoid
Macaque
2'-deoxynucleoside 5'-phosphate N-hydrolase 1
Cow
2'-deoxynucleoside 5'-phosphate N-hydrolase 1
Pig
2'-deoxynucleoside 5'-phosphate N-hydrolase 1
Opossum
2'-deoxynucleoside 5'-phosphate N-hydrolase 1
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleobase catabolism
Reactome
Purine catabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleobase catabolism
Purine catabolism
Protein-Protein Interactions (13)
1 – 10 of 13
ZNF593
Tbio
Novelty: 0.45276787
Score: 0.827
Data Source: STRINGDB
UBR1
Tbio
Family: Enzyme
Novelty: 0.00998888
Score: 0.816
Data Source: STRINGDB
GPA33
Tbio
Novelty: 0.0081206
Score: 0.543
Data Source: STRINGDB
ATG4A
Tbio
Family: Enzyme
Novelty: 0.04073485
Score: 0.519
Data Source: STRINGDB
SERPINB1
Tbio
Family: Enzyme
Novelty: 0.00267786
Score: 0.482
Data Source: STRINGDB
GAD2
Tbio
Family: Enzyme
Novelty: 0.00058427
Score: 0.457
Data Source: STRINGDB
CRYGC
Tbio
Novelty: 0.00083924
Score: 0.446
Data Source: STRINGDB
SERPINA9
Tbio
Novelty: 0.04989426
Score: 0.432
Data Source: STRINGDB
CLEC18C
Tdark
Novelty: 0.18974682
Score: 0.424
Data Source: STRINGDB
DNTT
Tchem
Family: Enzyme
Novelty: 0.00027411
Score: 0.412
Data Source: STRINGDB
Publication Statistics
PubMed Score  83.19

PubMed score by year
PubTator Score  12.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer