You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SPRY2
Protein sprouty homolog 2

Protein Summary
Description
May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377102
  • ENSP00000366306
  • ENSG00000136158
  • ENST00000377104
  • ENSP00000366308

Symbol
  • IGAN3
  • hSPRY2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.95
PubMedID
0.93
transcription factor binding site profile
0.93
gene perturbation
0.83
virus perturbation
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 127.11   (req: < 5)
Gene RIFs: 121   (req: <= 3)
Antibodies: 282   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 127.11   (req: >= 5)
Gene RIFs: 121   (req: > 3)
Antibodies: 282   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
2
1
2
2.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
2
2.2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sprouty RTK signaling antagonist 2
VGNC:5112
452616
Mouse
MGI:1345138
24064
Rat
RGD:1311472
306141
Dog
sprouty RTK signaling antagonist 2
VGNC:46766
485504
Horse
sprouty RTK signaling antagonist 2
VGNC:23544
100050086
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sprouty RTK signaling antagonist 2
Mouse
Rat
Dog
sprouty RTK signaling antagonist 2
Horse
sprouty RTK signaling antagonist 2
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O43597-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (24)
EGFR downregulation (R-HSA-182971)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
EGFR downregulation
Reactome
Negative regulation of FGFR1 signaling
Reactome
Negative regulation of FGFR2 signaling
Reactome
Negative regulation of FGFR3 signaling
Reactome
Negative regulation of FGFR4 signaling
Name
Explore in Pharos
Explore in Source
EGFR downregulation
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
Protein-Protein Interactions (122)
1 – 10 of 122
UBE2D2
Tbio
Novelty: 0.00603877
p_int: 0.974249295
p_ni: 0.015781272
p_wrong: 0.009969433
Score: 0.188
Data Source: BioPlex,STRINGDB
PLS1
Tbio
Novelty: 0.00538817
p_int: 0.971298097
p_ni: 0.028701903
Data Source: BioPlex
S100A13
Tbio
Novelty: 0.0283577
p_int: 0.95423145
p_ni: 0.041195312
p_wrong: 0.004573238
Score: 0.252
Data Source: BioPlex,STRINGDB
SNX3
Tbio
Novelty: 0.02703152
p_int: 0.869244697
p_ni: 0.125773916
p_wrong: 0.004981387
Score: 0.165
Data Source: BioPlex,STRINGDB
TES
Tbio
Novelty: 0.00052221
p_int: 0.856319705
p_ni: 0.100345711
p_wrong: 0.043334584
Score: 0.19
Data Source: BioPlex,STRINGDB
ZDHHC17
Tbio
Family: Enzyme
Novelty: 0.03288707
p_int: 0.806775769
p_ni: 0.193224201
p_wrong: 3.1e-8
Score: 0.163
Data Source: BioPlex,STRINGDB
CTH
Tchem
Family: Enzyme
Novelty: 0.0017155
p_int: 0.777396997
p_ni: 0.222552553
p_wrong: 0.00005045
Score: 0.165
Data Source: BioPlex,STRINGDB
CBL
Tbio
Family: Enzyme
Novelty: 0.00114929
Score: 0.998
Data Source: Reactome,STRINGDB
GRB2
Tchem
Novelty: 0.00091605
Score: 0.98
Data Source: Reactome,STRINGDB
EGFR
Tclin
Family: Kinase
Novelty: 0.00007274
Score: 0.976
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  127.11

PubMed score by year
PubTator Score  87.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: