Tbio SPRY2 Protein sprouty homolog 2

Protein Summary

Description

May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O43597
• B2R9J9
• Q5T6Z7
• Spry-2

Gene Name

• SPRY2

Ensembl ID

• ENST00000377102
• ENSP00000366306
• ENSG00000136158
• ENST00000377104
• ENSP00000366308

Symbol

• IGAN3
• hSPRY2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.95
PubMedID	0.93
transcription factor binding site profile	0.93
gene perturbation	0.83
virus perturbation	0.83

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Protein Sprouty Homolog 2

Protein / Signaling Molecule / Protein Sprouty Homolog 2

DTO Classes

Protein / Signaling / Protein Sprouty Homolog 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.29   (req: < 5)

Gene RIFs: 138   (req: <= 3)

Antibodies: 282   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.29   (req: >= 5)

Gene RIFs: 138   (req: > 3)

Antibodies: 282   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0