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Tbio
PSTPIP1
Proline-serine-threonine phosphatase-interacting protein 1

Protein Summary
Description
Involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation (By similarity). Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. Regulates endocytosis and cell migration in neutrophi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000558012
  • ENSP00000452746
  • ENSG00000140368
  • ENST00000559295
  • ENSP00000452743

Symbol
  • CD2BP1
  • H-PIP
  • PAPAS
  • CD2BP1
  • PSTPIP
  • CD2BP1L
  • CD2BP1S
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
tissue sample
0.7
disease perturbation
0.62
gene perturbation
0.55
hub protein
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.22   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 162   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.22   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 162   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (94)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Inflammasomes
Reactome
Innate Immune System
Reactome
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
Reactome
The NLRP3 inflammasome
Name
Explore in Pharos
Explore in Source
Immune System
Inflammasomes
Innate Immune System
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
The NLRP3 inflammasome
Gene Ontology Terms (19)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (111)
1 – 10 of 111
MEFV
Tbio
Novelty: 0.00090769
Score: 0.996
Data Source: Reactome,STRINGDB
PTPN12
Tchem
Family: Enzyme
Novelty: 0.01537047
Score: 0.947
Data Source: STRINGDB
ABL1
Tclin
Family: Kinase
Novelty: 0.00028825
Score: 0.924
Data Source: STRINGDB
PTPN18
Tbio
Family: Enzyme
Novelty: 0.15466786
Score: 0.876
Data Source: STRINGDB
WAS
Tbio
Novelty: 0.00072185
Score: 0.866
Data Source: STRINGDB
CD2
Tclin
Novelty: 0.0001768
Score: 0.814
Data Source: STRINGDB
WASL
Tbio
Novelty: 0.00386851
Score: 0.757
Data Source: STRINGDB
PTS
Tbio
Family: Enzyme
Novelty: 0.00144771
Score: 0.75
Data Source: STRINGDB
FNBP1
Tbio
Novelty: 0.06287005
Score: 0.74
Data Source: STRINGDB
TRIP10
Tbio
Novelty: 0.01228808
Score: 0.706
Data Source: STRINGDB
Publication Statistics
PubMed Score  86.22

PubMed score by year
PubTator Score  45.05

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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