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Tbio
PSTPIP1
Proline-serine-threonine phosphatase-interacting protein 1

Protein Summary
Description
Involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation (By similarity). Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. Regulates endocytosis and cell migration in neutrophi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000558012
  • ENSP00000452746
  • ENSG00000140368
  • ENST00000559295
  • ENSP00000452743

Symbol
  • CD2BP1
  • H-PIP
  • PAPAS
  • CD2BP1
  • PSTPIP
  • CD2BP1L
  • CD2BP1S
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
tissue sample
0.7
disease perturbation
0.62
gene perturbation
0.55
hub protein
0.53


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.9   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 162   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.9   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 162   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
72.4
BMI-adjusted hip circumference
2
4
5
65.3
myeloid white cell count
1
1
1
59.9
self reported educational attainment
1
1
1
42.3
leukocyte count
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
72.4
BMI-adjusted hip circumference
5
65.3
myeloid white cell count
1
59.9
self reported educational attainment
1
42.3
leukocyte count
1
30.2
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1321396
19200
Rat
RGD:1307557
300732
Dog
proline-serine-threonine phosphatase interacting protein 1
VGNC:45127
611757
Horse
proline-serine-threonine phosphatase interacting protein 1
VGNC:21975
100050881
Cow
proline-serine-threonine phosphatase interacting protein 1
VGNC:33486
513924
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
proline-serine-threonine phosphatase interacting protein 1
Horse
proline-serine-threonine phosphatase interacting protein 1
Cow
proline-serine-threonine phosphatase interacting protein 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O43586-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (94)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Inflammasomes
Reactome
Innate Immune System
Reactome
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
Reactome
The NLRP3 inflammasome
Name
Explore in Pharos
Explore in Source
Immune System
Inflammasomes
Innate Immune System
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
The NLRP3 inflammasome
Gene Ontology Terms (19)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (111)
1 – 10 of 111
MEFV
Tbio
Novelty:  0.00074419
Score:  0.996
Data Source:  Reactome,STRINGDB
PTPN12
Tchem
Family:  Enzyme
Novelty:  0.01333491
Score:  0.947
Data Source:  STRINGDB
ABL1
Tclin
Family:  Kinase
Novelty:  0.00023803
Score:  0.924
Data Source:  STRINGDB
PTPN18
Tbio
Family:  Enzyme
Novelty:  0.0950339
Score:  0.876
Data Source:  STRINGDB
WAS
Tbio
Novelty:  0.00087362
Score:  0.866
Data Source:  STRINGDB
CD2
Tclin
Novelty:  0.00037283
Score:  0.814
Data Source:  STRINGDB
WASL
Tbio
Novelty:  0.0029314
Score:  0.757
Data Source:  STRINGDB
PTS
Tbio
Family:  Enzyme
Novelty:  0.00279396
Score:  0.75
Data Source:  STRINGDB
FNBP1
Tbio
Novelty:  0.03879767
Score:  0.74
Data Source:  STRINGDB
TRIP10
Tbio
Novelty:  0.01553463
Score:  0.706
Data Source:  STRINGDB
Publication Statistics
PubMed Score  99.90

PubMed score by year
PubTator Score  45.05

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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