Tbio DENR Density-regulated protein

Protein Summary

Description

May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitmnet of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1. This gene encodes a protein whose expression was found to increase in cultured cells at high density but not during growth arrest. This gene was also shown to have increased expression in cells overexpressing HER-2/neu proto-oncogene. The protein contains an SUI1 domain. In budding yeast, SUI1 is a translation initiation factor that along with eIF-2 and the initiator tRNA-Met, directs the ribosome to the proper translation start site. Proteins similar to SUI have been found in mammals, insects, and plants. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O43583
• Q9H3U6
• Q9UKZ0
• DRP

Gene Name

• DENR

Ensembl ID

• ENST00000280557
• ENSP00000280557
• ENSG00000139726

Symbol

• DRP1
• DRP
• DRP1
• SMAP-3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (protein) perturbation	0.83
virus perturbation	0.83
transcription factor binding site profile	0.82
histone modification site profile	0.8
transcription factor perturbation	0.8

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Nuclease / Density-regulated Protein

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Initiation Factor / Density-regulated Protein

DTO Classes

Protein / Enzyme / Nuclease / Density-regulated Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 360.07   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 179   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 360.07   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0