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Tbio
SYT7
Synaptotagmin-7

Protein Summary
Description
Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory and synaptic vesicles through Ca(2+) and phospholipid binding to the C2 domain (By similarity). Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). SYT7 binds Ca(2+) with high affinity and slow kinetics compared to other synaptotagmins (By similarity). Involved in Ca(2+)-triggered lysosomal exocytosis, a major component of the plasma membrane repair (PubMed:11342594). Ca(2+)-regulated delivery of lysosomal membranes to the cell surface is also involved in the phagocytic uptake of particles by macrophages (By similarity). Ca(2+)-triggered lysosomal exocytosis also plays a role in bone remodeling by regulating secretory pathways in osteoclasts and osteoblasts (By similarity). In case of infection, involved in participates cell invasion by Trypanosoma cruzi via Ca(2+)-triggered lysosomal exocytosis (PubMed:113 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263846
  • ENSP00000263846
  • ENSG00000011347
  • ENST00000535826
  • ENSP00000437720
  • ENST00000539008
  • ENSP00000439694
  • ENST00000540677
  • ENSP00000444201
  • ENST00000542670
  • ENSP00000444019
  • ENST00000542836
  • ENSP00000444568

Symbol
  • PCANAP7
  • IPCA7
  • IPCA-7
  • SYTVII
  • PCANAP7
  • SYT-VII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.9
transcription factor
0.77
transcription factor binding site profile
0.74
tissue sample
0.68
microRNA
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 136.78   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 235   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 136.78   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 235   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (83)
P58400
Tbio
Novelty:  0.00454659
Score:  0.956
Data Source:  STRINGDB
Q9ULB1
Tbio
Novelty:  0.00454659
Score:  0.956
Data Source:  STRINGDB
P58401
Tbio
Novelty:  0.01252742
Score:  0.922
Data Source:  STRINGDB
Q9P2S2
Tbio
Novelty:  0.01252742
Score:  0.922
Data Source:  STRINGDB
Q9Y4C0
Tbio
Novelty:  0.00999084
Score:  0.918
Data Source:  STRINGDB
Q9HDB5
Tbio
Novelty:  0.00999084
Score:  0.918
Data Source:  STRINGDB
STX1A
Tbio
Novelty:  0.00087207
Score:  0.871
Data Source:  STRINGDB
CPLX1
Tbio
Novelty:  0.01434543
Score:  0.845
Data Source:  STRINGDB
SNAP25
Tclin
Novelty:  0.00148905
Score:  0.83
Data Source:  STRINGDB
STX3
Tbio
Novelty:  0.01055819
Score:  0.807
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Neurexins and neuroligins (R-HSA-6794361)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neurexins and neuroligins
Reactome
Neuronal System
Reactome
Protein-protein interactions at synapses
Name
Explore in Pharos
Explore in Source
Neurexins and neuroligins
Neuronal System
Protein-protein interactions at synapses
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (49)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
3
2
3
77.9
self reported educational attainment
2
2
2
66.2
mean arterial pressure
1
1
1
51.7
cognitive function measurement
3
1
3
48.5
esterified cholesterol measurement
1
1
1
46.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
3
77.9
self reported educational attainment
2
66.2
mean arterial pressure
1
51.7
cognitive function measurement
3
48.5
esterified cholesterol measurement
1
46.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
synaptotagmin 7
VGNC:11651
451239
Mouse
MGI:1859545
54525
Rat
RGD:62013
59267
Dog
synaptotagmin 7
VGNC:47050
483796
Horse
synaptotagmin 7
VGNC:23825
100062526
Species
Name
OMA
EggNOG
Inparanoid
Chimp
synaptotagmin 7
Mouse
Rat
Dog
synaptotagmin 7
Horse
synaptotagmin 7
Publication Statistics
PubMed Score 136.78
PubMed score by year
PubTator Score 39.49
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title