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Tbio
AKAP10
A-kinase anchor protein 10, mitochondrial

Protein Summary
Description
Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity). This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins bind to the regulatory subunits of protein kinase A (PKA) and confine the holoenzyme to discrete locations within the cell. The encoded protein is localized to mitochondria and interacts with both the type I and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000225737
  • ENSP00000225737
  • ENSG00000108599

Symbol
  • PRKA10
  • AKAP-10
  • D-AKAP2
  • D-AKAP-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
transcription factor binding site profile
0.82
tissue sample
0.64
kinase perturbation
0.6
transcription factor
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.1   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 242   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.1   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
2
2
57.8
neutrophil count
2
2
2
56.6
mean platelet volume
1
1
1
31
worry measurement
1
1
1
5.9
reticulocyte count
2
1
2
3.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
57.8
neutrophil count
2
56.6
mean platelet volume
1
31
worry measurement
1
5.9
reticulocyte count
2
3.9
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
A-kinase anchoring protein 10
VGNC:6330
468376
Macaque
A-kinase anchoring protein 10
710970
Mouse
MGI:1890218
56697
Rat
RGD:1308869
360540
Dog
A-kinase anchoring protein 10
VGNC:37752
609073
Species
Name
OMA
EggNOG
Inparanoid
Chimp
A-kinase anchoring protein 10
Macaque
A-kinase anchoring protein 10
Mouse
Rat
Dog
A-kinase anchoring protein 10
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O43572-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Factors involved in megakaryocyte development and platelet production (R-HSA-983231)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Factors involved in megakaryocyte development and platelet production
Hemostasis
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (48)
1 – 10 of 48
OVGP1
Tbio
Family: Enzyme
Novelty: 0.00615902
p_int: 0.999999765
p_ni: 4e-8
p_wrong: 1.94e-7
Data Source: BioPlex
PRKAR2B
Tbio
Family: Enzyme
Novelty: 0.00456972
Score: 0.978
Data Source: Reactome,STRINGDB
PRKAR1A
Tbio
Family: Enzyme
Novelty: 0.00311432
Score: 0.97
Data Source: Reactome,STRINGDB
PRKAR2A
Tbio
Family: Enzyme
Novelty: 0.06183318
Score: 0.943
Data Source: Reactome,STRINGDB
PRKAR1B
Tbio
Family: Enzyme
Novelty: 0.05355517
Score: 0.929
Data Source: Reactome,STRINGDB
PRKACB
Tchem
Family: Kinase
Novelty: 0.01962222
Score: 0.924
Data Source: Reactome,STRINGDB
PRKACA
Tchem
Family: Kinase
Novelty: 0.03869658
Score: 0.916
Data Source: Reactome,STRINGDB
PRKACG
Tbio
Family: Kinase
Novelty: 0.11080061
Score: 0.914
Data Source: Reactome,STRINGDB
AKAP1
Tbio
Family: Epigenetic
Novelty: 0.00437217
Score: 0.801
Data Source: STRINGDB
C2orf88
Tdark
Family: Enzyme
Novelty: 0.39740724
Score: 0.787
Data Source: STRINGDB
Publication Statistics
PubMed Score  31.10

PubMed score by year
PubTator Score  26.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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