Protein Summary
Reversible hydration of carbon dioxide. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10% of clear cell renal carcinomas. Three transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2014]
- ENST00000178638
- ENSP00000178638
- ENSG00000074410
- ENST00000344366
- ENSP00000343088
- CAXII
- CA-XII
- T18816
- HsT18816
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor perturbation | 0.98 | ||
kinase perturbation | 0.91 | ||
virus perturbation | 0.85 | ||
PubMedID | 0.84 | ||
gene perturbation | 0.83 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 256 (req: < 5)
Gene RIFs: 30 (req: <= 3)
Antibodies: 460 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 256 (req: >= 5)
Gene RIFs: 30 (req: > 3)
Antibodies: 460 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2029
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 19
Approved Drugs (19)
1 – 10 of 19
Active Ligands (2029)
1 – 10 of 2029
Protein Data Bank (16)
1 – 5 of 16
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
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PDB Structure Id | M.W. | Resolution | Pub Year |
---|
Pathways (4)
Reactome (2)
KEGG (2)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 2 of 2
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Reversible hydration of carbon dioxide | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Metabolism | ||||
Reversible hydration of carbon dioxide | ||||
Gene Ontology Terms (6)
Functions (2)
Components (2)
Processes (2)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | ProtInc | |||
Protein-Protein Interactions (45)
1 – 10 of 45
TMEM30B
Novelty: 0.41265163
p_int: 0.988136691
p_ni: 5e-8
p_wrong: 0.011863259
Score: 0.188
Data Source: BioPlex,STRINGDB
CYP24A1
Family: Enzyme
Novelty: 0.00108437
Score: 0.795
Data Source: STRINGDB
UHMK1
Family: Kinase
Novelty: 0.00180095
Score: 0.67
Data Source: STRINGDB
HIGD1A
Novelty: 0.07704751
Score: 0.626
Data Source: STRINGDB
SLC9A1
Family: Transporter
Novelty: 0.00112175
Score: 0.611
Data Source: STRINGDB
SLC4A4
Family: Transporter
Novelty: 0.00221797
Score: 0.581
Data Source: STRINGDB
GREB1
Novelty: 0.02488332
Score: 0.575
Data Source: STRINGDB
FOXF1
Family: TF
Novelty: 0.01072169
Score: 0.571
Data Source: STRINGDB
SNRPB
Novelty: 0.01137048
Score: 0.555
Data Source: STRINGDB
TFF1
Novelty: 0.00363238
Score: 0.549
Data Source: STRINGDB
Publication Statistics
PubMed Score 256.00
PubMed score by year
PubTator Score 186.98
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDAS
1-70
LTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHF
70-140
AAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEEL
140-210
LPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKF
210-280
DERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMET
280-350
EAHA
350-354
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
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