You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
CA12
Carbonic anhydrase 12

Protein Summary
Description
Reversible hydration of carbon dioxide. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10% of clear cell renal carcinomas. Three transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000178638
  • ENSP00000178638
  • ENSG00000074410
  • ENST00000344366
  • ENSP00000343088

Symbol
  • CAXII
  • CA-XII
  • T18816
  • HsT18816
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
kinase perturbation
0.91
virus perturbation
0.85
PubMedID
0.84
gene perturbation
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 281.23   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 460   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 281.23   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 460   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2029
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 19
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
dental caries
2
1
2
85.6
dentures
2
1
2
70.6
glomerular filtration rate
1
1
0
5.9
15
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
dental caries
2
85.6
dentures
2
70.6
glomerular filtration rate
0
5.9
15
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
carbonic anhydrase 12
705838
Mouse
MGI:1923709
76459
Rat
RGD:1306612
363085
Dog
carbonic anhydrase 12
VGNC:38607
478333
Horse
carbonic anhydrase 12
VGNC:15961
100054028
Species
Name
OMA
EggNOG
Inparanoid
Macaque
carbonic anhydrase 12
Mouse
Rat
Dog
carbonic anhydrase 12
Horse
carbonic anhydrase 12
Protein Data Bank (16)
1 – 5 of 16
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Reversible hydration of carbon dioxide
Name
Explore in Pharos
Explore in Source
Metabolism
Reversible hydration of carbon dioxide
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (45)
1 – 10 of 45
TMEM30B
Tbio
Novelty: 0.26735006
p_int: 0.988136691
p_ni: 5e-8
p_wrong: 0.011863259
Score: 0.188
Data Source: BioPlex,STRINGDB
CYP24A1
Tchem
Family: Enzyme
Novelty: 0.00107155
Score: 0.795
Data Source: STRINGDB
UHMK1
Tbio
Family: Kinase
Novelty: 0.04117277
Score: 0.67
Data Source: STRINGDB
HIGD1A
Tbio
Novelty: 0.06248108
Score: 0.626
Data Source: STRINGDB
SLC9A1
Tchem
Family: Transporter
Novelty: 0.00096678
Score: 0.611
Data Source: STRINGDB
SLC4A4
Tbio
Family: Transporter
Novelty: 0.00352439
Score: 0.581
Data Source: STRINGDB
GREB1
Tbio
Novelty: 0.01644388
Score: 0.575
Data Source: STRINGDB
FOXF1
Tbio
Family: TF
Novelty: 0.00787458
Score: 0.571
Data Source: STRINGDB
SNRPB
Tbio
Novelty: 0.01503535
Score: 0.555
Data Source: STRINGDB
TFF1
Tbio
Novelty: 0.00295014
Score: 0.549
Data Source: STRINGDB
Publication Statistics
PubMed Score  281.23

PubMed score by year
PubTator Score  186.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer