Tclin CA12 Carbonic anhydrase 12

Protein Summary

Description

Reversible hydration of carbon dioxide. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10% of clear cell renal carcinomas. Three transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2014]

Uniprot Accession IDs

• O43570
• B2RE24
• Q53YE5
• Q9BWG2

Gene Name

• CA12

Ensembl ID

• ENST00000178638
• ENSP00000178638
• ENSG00000074410
• ENST00000344366
• ENSP00000343088

Symbol

• CAXII
• CA-XII
• T18816
• HsT18816

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.98
kinase perturbation	0.91
virus perturbation	0.85
PubMedID	0.84
gene perturbation	0.83

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 256   (req: < 5)

Gene RIFs: 30   (req: <= 3)

Antibodies: 460   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 256   (req: >= 5)

Gene RIFs: 30   (req: > 3)

Antibodies: 460   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2029

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 19

Approved Drugs (19)

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1 – 10 of 19

acetazolamide

CA12Tclin Enzyme

INHIBITOR Ki: 8.6

ethoxzolamide

CA12Tclin Enzyme

INHIBITOR Ki: 7.66

topiramate

CA12Tclin Enzyme

Ki: 8.42000008

celecoxib

CA12Tclin Enzyme

Ki: 7.73999977

dichlorphenamide

CA12Tclin Enzyme

INHIBITOR Ki: 7.301

dorzolamide

CA12Tclin Enzyme

Ki: 8.46000004

brinzolamide

CA12Tclin Enzyme

Ki: 8.52000046

imatinib

CA12Tclin Enzyme

Ki: 6.01

valdecoxib

CA12Tclin Enzyme

Ki: 7.88999987

sulpiride

CA12Tclin Enzyme

Ki: 8.40999985

Active Ligands (2029)

Explore Active Ligands

1 – 10 of 2029

CHEMBL19

CA12Tclin Enzyme

Ki: 8.47

CHEMBL77517

CA12Tclin Enzyme

Ki: 8.47000027

CHEMBL21

CA12Tclin Enzyme

Ki: 7.43

CHEMBL268439

CA12Tclin Enzyme

Ki: 7.07

CHEMBL73962

CA12Tclin Enzyme

Ki: 8.46000004

CHEMBL6633

CA12Tclin Enzyme

Ki: 8.47

CHEMBL266026

CA12Tclin Enzyme

Ki: 8.46

CHEMBL7146

CA12Tclin Enzyme

Ki: 8.35

CHEMBL265674

CA12Tclin Enzyme

Ki: 7.48

CHEMBL7087

CA12Tclin Enzyme

Ki: 8.49

Protein Data Bank (16)

1 – 5 of 16

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (4)

Reactome (2)

KEGG (2)

Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:

5

1 – 2 of 2

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Reversible hydration of carbon dioxide	12 targets	R-HSA-1475029

Name	Explore in Pharos	Explore in Source
Metabolism	2112 targets	R-HSA-1430728
Reversible hydration of carbon dioxide	12 targets	R-HSA-1475029

Gene Ontology Terms (6)

Functions (2)

Components (2)

Processes (2)

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
carbonate dehydratase activity	Traceable Author Statement (TAS)	Reactome
zinc ion binding	Traceable Author Statement (TAS)	ProtInc

Protein-Protein Interactions (45)

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1 – 10 of 45

• See Interactions on String-DB

TMEM30B

Tbio

Novelty: 0.41265163

p_int: 0.988136691

p_ni: 5e-8

p_wrong: 0.011863259

Score: 0.188

Data Source: BioPlex,STRINGDB

CYP24A1

Tchem

Family: Enzyme

Novelty: 0.00108437

Score: 0.795

Data Source: STRINGDB

UHMK1

Tbio

Family: Kinase

Novelty: 0.00180095

Score: 0.67

Data Source: STRINGDB

HIGD1A

Tbio

Novelty: 0.07704751

Score: 0.626

Data Source: STRINGDB

SLC9A1

Tchem

Family: Transporter

Novelty: 0.00112175

Score: 0.611

Data Source: STRINGDB

SLC4A4

Tbio

Family: Transporter

Novelty: 0.00221797

Score: 0.581

Data Source: STRINGDB

GREB1

Tbio

Novelty: 0.02488332

Score: 0.575

Data Source: STRINGDB

FOXF1

Tbio

Family: TF

Novelty: 0.01072169

Score: 0.571

Data Source: STRINGDB

SNRPB

Tbio

Novelty: 0.01137048

Score: 0.555

Data Source: STRINGDB

TFF1

Tbio

Novelty: 0.00363238

Score: 0.549

Data Source: STRINGDB

Publication Statistics

PubMed Score  256.00

PubMed score by year

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PubTator Score  186.98

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDAS

1-70

LTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHF

70-140

AAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEEL

140-210

LPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKF

210-280

DERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMET

280-350

EAHA

350-354

MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA

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Uniprot Keyword

3D-structure
Alternative splicing
Complete proteome
Disease mutation
Disulfide bond
Glycoprotein
Lyase
Membrane
Metal-binding
Reference proteome