Protein Summary
Reversible hydration of carbon dioxide. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10% of clear cell renal carcinomas. Three transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2014]
- ENST00000178638
- ENSP00000178638
- ENSG00000074410
- ENST00000344366
- ENSP00000343088
- CAXII
- CA-XII
- T18816
- HsT18816
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.98 | ||
kinase perturbation | 0.91 | ||
virus perturbation | 0.85 | ||
PubMedID | 0.84 | ||
gene perturbation | 0.83 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 281.23 (req: < 5)
Gene RIFs: 30 (req: <= 3)
Antibodies: 460 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 281.23 (req: >= 5)
Gene RIFs: 30 (req: > 3)
Antibodies: 460 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2029
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 19
Approved Drugs (19)
1 – 10 of 19
Active Ligands (2029)
1 – 10 of 2029
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
dental caries | 2 | 1 | 2 | 85.6 | |||||
dentures | 2 | 1 | 2 | 70.6 | |||||
glomerular filtration rate | 1 | 1 | 0 | 5.9 | 15 | ||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
dental caries | 2 | 85.6 | |||||
dentures | 2 | 70.6 | |||||
glomerular filtration rate | 0 | 5.9 | 15 | ||||
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | carbonic anhydrase 12 | 705838 | ||||||
Mouse | MGI:1923709 | 76459 | ||||||
Rat | RGD:1306612 | 363085 | ||||||
Dog | carbonic anhydrase 12 | VGNC:38607 | 478333 | |||||
Horse | carbonic anhydrase 12 | VGNC:15961 | 100054028 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | carbonic anhydrase 12 | |||||
Mouse | ||||||
Rat | ||||||
Dog | carbonic anhydrase 12 | |||||
Horse | carbonic anhydrase 12 | |||||
Protein Data Bank (16)
1 – 5 of 16
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (4)
Reactome (2)
KEGG (2)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 2 of 2
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Reversible hydration of carbon dioxide | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Reversible hydration of carbon dioxide | ||||
Gene Ontology Terms (6)
Functions (2)
Components (2)
Processes (2)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | ProtInc | |||
Protein-Protein Interactions (45)
1 – 10 of 45
TMEM30B
Novelty: 0.26735006
p_int: 0.988136691
p_ni: 5e-8
p_wrong: 0.011863259
Score: 0.188
Data Source: BioPlex,STRINGDB
CYP24A1
Family: Enzyme
Novelty: 0.00107155
Score: 0.795
Data Source: STRINGDB
UHMK1
Family: Kinase
Novelty: 0.04117277
Score: 0.67
Data Source: STRINGDB
HIGD1A
Novelty: 0.06248108
Score: 0.626
Data Source: STRINGDB
SLC9A1
Family: Transporter
Novelty: 0.00096678
Score: 0.611
Data Source: STRINGDB
SLC4A4
Family: Transporter
Novelty: 0.00352439
Score: 0.581
Data Source: STRINGDB
GREB1
Novelty: 0.01644388
Score: 0.575
Data Source: STRINGDB
FOXF1
Family: TF
Novelty: 0.00787458
Score: 0.571
Data Source: STRINGDB
SNRPB
Novelty: 0.01503535
Score: 0.555
Data Source: STRINGDB
TFF1
Novelty: 0.00295014
Score: 0.549
Data Source: STRINGDB
Publication Statistics
PubMed Score 281.23
PubMed score by year
PubTator Score 186.98
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: