You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RGS14
Regulator of G-protein signaling 14

Protein Summary
Description
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o) alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resista ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000408923
  • ENSP00000386229
  • ENSG00000169220
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.93
molecular function
0.88
disease perturbation
0.87
kinase perturbation
0.76
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.15   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 298   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.15   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 298   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
4
0
1.2
97.2
2
2
0
1.1
85.9
hematocrit
2
2
2
83.1
hemoglobin measurement
2
2
2
82.6
fibroblast growth factor 23 measurement
2
2
2
80.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
97.2
0
1.1
85.9
hematocrit
2
83.1
hemoglobin measurement
2
82.6
fibroblast growth factor 23 measurement
2
80.1
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (14)
G alpha (i) signalling events (R-HSA-418594)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
GPCR downstream signalling
Signal Transduction
Signaling by GPCR
Gene Ontology Terms (42)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (52)
1 – 10 of 52
GNAI3
Tbio
Novelty: 0.03484857
p_int: 0.999999215
p_ni: 2.38e-7
p_wrong: 5.46e-7
Score: 0.996
Data Source: BioPlex,STRINGDB
GNAI1
Tbio
Novelty: 0.0488971
p_int: 0.996610103
p_ni: 2.2e-8
p_wrong: 0.003389875
Score: 0.999
Data Source: BioPlex,STRINGDB
GNAI2
Tbio
Novelty: 0.03014729
Score: 0.983
Data Source: STRINGDB
GNAT3
Tbio
Novelty: 0.00702357
Score: 0.967
Data Source: STRINGDB
RAP1A
Tchem
Family: Enzyme
Novelty: 0.00375413
Score: 0.929
Data Source: STRINGDB
GNAO1
Tbio
Novelty: 0.00315097
Score: 0.91
Data Source: STRINGDB
ITGB2
Tclin
Novelty: 0.00185859
Score: 0.82
Data Source: STRINGDB
RAP1B
Tbio
Family: Enzyme
Novelty: 0.00627538
Score: 0.813
Data Source: STRINGDB
ITGAL
Tclin
Novelty: 0.00099016
Score: 0.813
Data Source: STRINGDB
ITGAM
Tbio
Novelty: 0.00017521
Score: 0.812
Data Source: STRINGDB
Publication Statistics
PubMed Score  57.15

PubMed score by year
PubTator Score  29.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: