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Tbio
LAT
Linker for activation of T-cells family member 1

Protein Summary
Description
Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins an ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360872
  • ENSP00000354119
  • ENSG00000213658
  • ENST00000395456
  • ENSP00000378841
  • ENST00000395461
  • ENSP00000378845
  • ENST00000454369
  • ENSP00000398793
  • ENST00000564277
  • ENSP00000457036
  • ENST00000566177
  • ENSP00000456761

Symbol
  • LAT1
  • pp36
  • IMD52
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
hub protein
0.96
biological process
0.88
protein complex
0.87
biological term
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.25   (req: < 5)
Gene RIFs: 68   (req: <= 3)
Antibodies: 918   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.25   (req: >= 5)
Gene RIFs: 68   (req: > 3)
Antibodies: 918   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
65.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
65.5
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
linker for activation of T-cells
743295
Mouse
MGI:1342293
16797
Rat
RGD:620802
81511
Dog
linker for activation of T cells
VGNC:42596
607947
Horse
linker for activation of T cells
VGNC:19595
100064430
Species
Name
OMA
EggNOG
Inparanoid
Chimp
linker for activation of T-cells
Mouse
Rat
Dog
linker for activation of T cells
Horse
linker for activation of T cells
Pathways (49)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Cytokine Signaling in Immune system
Reactome
DAP12 interactions
Reactome
DAP12 signaling
Reactome
FCERI mediated Ca+2 mobilization
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Cytokine Signaling in Immune system
DAP12 interactions
DAP12 signaling
FCERI mediated Ca+2 mobilization
Protein-Protein Interactions (179)
1 – 10 of 179
ZAP70
Tchem
Family: Kinase
Novelty: 0.0011564
Score: 0.995
Data Source: Reactome,STRINGDB
LCP2
Tbio
Novelty: 0.00512968
Score: 0.994
Data Source: Reactome,STRINGDB
GRB2
Tchem
Novelty: 0.00091605
Score: 0.992
Data Source: Reactome,STRINGDB
PLCG1
Tchem
Family: Enzyme
Novelty: 0.00110273
Score: 0.992
Data Source: Reactome,STRINGDB
LCK
Tclin
Family: Kinase
Novelty: 0.00058377
Score: 0.991
Data Source: Reactome,STRINGDB
SYK
Tclin
Family: Kinase
Novelty: 0.00058994
Score: 0.99
Data Source: Reactome,STRINGDB
GRAP2
Tbio
Novelty: 0.00503901
Score: 0.987
Data Source: Reactome,STRINGDB
VAV1
Tchem
Novelty: 0.00180518
Score: 0.985
Data Source: Reactome,STRINGDB
FYN
Tclin
Family: Kinase
Novelty: 0.00072167
Score: 0.984
Data Source: STRINGDB
ITK
Tclin
Family: Kinase
Novelty: 0.00054195
Score: 0.981
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  97.25

PubMed score by year
PubTator Score  432.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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