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Tbio
FRS3
Fibroblast growth factor receptor substrate 3

Protein Summary
Description
Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2. This gene encodes a substrate for the fibroblast growth factor receptor. The encoded protein is found in the peripheral plasma membrane and links fibroblast growth factor receptor stimulation to activators of Ras. The encoded protein down-regulates extracellular regulated kinase 2 through direct binding. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259748
  • ENSP00000259748
  • ENSG00000137218
  • ENST00000373018
  • ENSP00000362109

Symbol
  • SNT2
  • FRS2B
  • SNT-2
  • FRS2beta
  • FRS2-beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.74
histone modification site profile
0.65
cell line
0.62
kinase perturbation
0.6
tissue sample
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.95   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 197   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.95   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 197   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
puberty onset measurement
1
1
1
70.6
body mass index
1
1
1
54.9
appendicular lean mass
1
1
1
52.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
puberty onset measurement
1
70.6
body mass index
1
54.9
appendicular lean mass
1
52.5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fibroblast growth factor receptor substrate 3
VGNC:2836
107975139
Macaque
fibroblast growth factor receptor substrate 3
694462
Mouse
MGI:2135965
107971
Rat
RGD:1310226
316213
Dog
fibroblast growth factor receptor substrate 3
VGNC:40987
481794
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fibroblast growth factor receptor substrate 3
Macaque
fibroblast growth factor receptor substrate 3
Mouse
Rat
Dog
fibroblast growth factor receptor substrate 3
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O43559-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (89)
Activated NTRK2 signals through FRS2 and FRS3 (R-HSA-9028731)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 26
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NTRK2 signals through FRS2 and FRS3
Reactome
Cytokine Signaling in Immune system
Reactome
Downstream signaling of activated FGFR1
Reactome
Downstream signaling of activated FGFR2
Reactome
Downstream signaling of activated FGFR3
Name
Explore in Pharos
Explore in Source
Activated NTRK2 signals through FRS2 and FRS3
Cytokine Signaling in Immune system
Downstream signaling of activated FGFR1
Downstream signaling of activated FGFR2
Downstream signaling of activated FGFR3
Protein-Protein Interactions (62)
1 – 10 of 62
PTPN11
Tchem
Family: Enzyme
Novelty: 0.00073124
Score: 0.98
Data Source: Reactome,STRINGDB
NTRK1
Tclin
Family: Kinase
Novelty: 0.00033453
Score: 0.97
Data Source: STRINGDB
GRB2
Tchem
Novelty: 0.00091605
Score: 0.967
Data Source: Reactome,STRINGDB
ALK
Tclin
Family: Kinase
Novelty: 0.00022375
Score: 0.962
Data Source: STRINGDB
NTRK2
Tclin
Family: Kinase
Novelty: 0.00054534
Score: 0.962
Data Source: Reactome,STRINGDB
NTRK3
Tclin
Family: Kinase
Novelty: 0.00177321
Score: 0.933
Data Source: STRINGDB
FGFR4
Tclin
Family: Kinase
Novelty: 0.00258329
Score: 0.931
Data Source: Reactome,STRINGDB
BDNF
Tbio
Novelty: 0.00006891
Score: 0.928
Data Source: Reactome,STRINGDB
NGF
Tchem
Novelty: 0.00008139
Score: 0.925
Data Source: STRINGDB
SHC1
Tchem
Novelty: 0.00083615
Score: 0.922
Data Source: STRINGDB
Publication Statistics
PubMed Score  11.95

PubMed score by year
PubTator Score  9.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer