Tbio FRS3 Fibroblast growth factor receptor substrate 3

Protein Summary

Description

Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2. This gene encodes a substrate for the fibroblast growth factor receptor. The encoded protein is found in the peripheral plasma membrane and links fibroblast growth factor receptor stimulation to activators of Ras. The encoded protein down-regulates extracellular regulated kinase 2 through direct binding. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• O43559
• Q5T3D5
• FGFR substrate 3

Gene Name

• FRS3

Ensembl ID

• ENST00000259748
• ENSP00000259748
• ENSG00000137218
• ENST00000373018
• ENSP00000362109

Symbol

• SNT2
• FRS2B
• SNT-2
• FRS2beta
• FRS2-beta

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.74
histone modification site profile	0.65
cell line	0.62
kinase perturbation	0.6
tissue sample	0.59

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.41   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 197   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.41   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 197   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0