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Tbio
TNFSF14
Tumor necrosis factor ligand superfamily member 14

Protein Summary
Description
Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus. The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000245912
  • ENSP00000245912
  • ENSG00000125735
  • ENST00000599359
  • ENSP00000469049

Symbol
  • HVEML
  • LIGHT
  • LTg
  • CD258
  • HVEML
  • LIGHT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.98
biological term
0.69
molecular function
0.63
phenotype
0.6
virus perturbation
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.3   (req: < 5)
Gene RIFs: 66   (req: <= 3)
Antibodies: 595   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.3   (req: >= 5)
Gene RIFs: 66   (req: > 3)
Antibodies: 595   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (90)
MFF
Tbio
Novelty:  0.00411615
p_int:  0.999757714
p_ni:  0.000021492
p_wrong:  0.000220794
Data Source:  BioPlex
KCTD2
Tdark
Novelty:  0.42992811
p_int:  0.99434193
p_ni:  0.00157746
p_wrong:  0.004080609
Data Source:  BioPlex
DNAJB9
Tbio
Novelty:  0.00536296
p_int:  0.993745273
p_ni:  0.006254391
p_wrong:  3.37e-7
Data Source:  BioPlex
TAMM41
Tbio
Family:  Enzyme
Novelty:  0.06004824
p_int:  0.991730128
p_ni:  0.007716767
p_wrong:  0.000553106
Data Source:  BioPlex
YTHDF1
Tbio
Novelty:  0.02063275
p_int:  0.976766972
p_ni:  0.023232953
p_wrong:  7.5e-8
Data Source:  BioPlex
CCPG1
Tbio
Novelty:  0.07685013
p_int:  0.934839948
p_ni:  0.06516005
p_wrong:  2e-9
Data Source:  BioPlex
HOXD13
Tbio
Family:  TF
Novelty:  0.00404722
p_int:  0.884631061
p_ni:  0.115288567
p_wrong:  0.000080372
Data Source:  BioPlex
SLC25A24
Tbio
Family:  Transporter
Novelty:  0.06151955
p_int:  0.781592293
p_ni:  0.193541093
p_wrong:  0.024866614
Data Source:  BioPlex
TNFRSF14
Tbio
Novelty:  0.00345486
Score:  0.995
Data Source:  STRINGDB
LTBR
Tbio
Novelty:  0.003823
Score:  0.981
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Cytokine Signaling in Immune system (R-HSA-1280215)

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Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Reactome
TNFR2 non-canonical NF-kB pathway
Reactome
TNFs bind their physiological receptors
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
TNFR2 non-canonical NF-kB pathway
TNFs bind their physiological receptors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
7
3
0
1.4
96.9
tumor necrosis factor ligand superfamily member 14 measurement
1
3
3
96.7
2
2
0
1.6
94.1
atrophic macular degeneration
2
2
0
1.8
94.1
monocyte count
3
2
3
88.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
96.9
tumor necrosis factor ligand superfamily member 14 measurement
3
96.7
0
1.6
94.1
atrophic macular degeneration
0
1.8
94.1
monocyte count
3
88.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TNF superfamily member 14
VGNC:3583
468687
Macaque
TNF superfamily member 14
701451
Mouse
MGI:1355317
50930
Rat
RGD:1588572
301133
Dog
TNF superfamily member 14
VGNC:47670
611306
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TNF superfamily member 14
Macaque
TNF superfamily member 14
Mouse
Rat
Dog
TNF superfamily member 14
Publication Statistics
PubMed Score 71.30
PubMed score by year
PubTator Score 41.86
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title