Tbio TNFSF14 Tumor necrosis factor ligand superfamily member 14

Protein Summary

Description

Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus. The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O43557
• A8K7M2
• C9J5H4
• O75476
• Q6FHA1
• Q8WVF8
• Q96LD2

Gene Name

• TNFSF14

Ensembl ID

• ENST00000245912
• ENSP00000245912
• ENSG00000125735
• ENST00000599359
• ENSP00000469049

Symbol

• HVEML
• LIGHT
• LTg
• CD258
• HVEML
• LIGHT

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.98
biological term	0.69
molecular function	0.63
phenotype	0.6
virus perturbation	0.59

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Tumor Necrosis Factor Family Member / Tumor Necrosis Factor Ligand Superfamily Member 14

DTO Classes

Protein / Signaling / Cytokine / Tumor Necrosis Factor Family Member / Tumor Necrosis Factor Ligand Superfamily Member 14

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.23   (req: < 5)

Gene RIFs: 97   (req: <= 3)

Antibodies: 595   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.23   (req: >= 5)

Gene RIFs: 97   (req: > 3)

Antibodies: 595   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0