You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
XRCC3
DNA repair protein XRCC3

Protein Summary
Description
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C. This gene encodes a member of the RecA/Rad51-related protein family that p ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000352127
  • ENSP00000343392
  • ENSG00000126215
  • ENST00000553264
  • ENSP00000451974
  • ENST00000554913
  • ENSP00000451362
  • ENST00000555055
  • ENSP00000452598

Symbol
  • CMM6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
disease
0.88
phenotype
0.81
cell type or tissue
0.67
small molecule perturbation
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 361.83   (req: < 5)
Gene RIFs: 285   (req: <= 3)
Antibodies: 536   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 361.83   (req: >= 5)
Gene RIFs: 285   (req: > 3)
Antibodies: 536   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0