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Tbio
CHST10
Carbohydrate sulfotransferase 10

Protein Classes
Protein Summary
Description
Catalyzes the transfer of sulfate to position 3 of terminal glucuronic acid of both protein- and lipid-linked oligosaccharides. Participates in biosynthesis of HNK-1 carbohydrate structure, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult. May be indirectly involved in synapse plasticity of the hippocampus, via its role in HNK-1 biosynthesis. This protein encoded by this gene transfers sulfate to the C-3 hydroxyl of terminal glucuronic acid of protein- and lipid-linked oligosaccharides. This protein was first identified as a sulfotransferase that acts on the human natural killer-1 (HNK-1) glycan; HNK-1 is a carbohydrate involved in neurodevelopment and synaptic plasticity.[provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264249
  • ENSP00000264249
  • ENSG00000115526
  • ENST00000409701
  • ENSP00000387309

Symbol
  • HNK1ST
  • HNK-1ST
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.75
small molecule perturbation
0.75
histone modification site profile
0.66
disease perturbation
0.62
PubMedID
0.51


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.07   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 176   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.07   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
3
10
8
6.1
86.4
mathematical ability
2
3
3
79.3
self reported educational attainment
2
2
3
78.7
household income
2
8
8
76.5
body mass index
1
1
1
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
8
6.1
86.4
mathematical ability
3
79.3
self reported educational attainment
3
78.7
household income
8
76.5
body mass index
1
54.4
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
carbohydrate sulfotransferase 10
VGNC:195
459446
Macaque
carbohydrate sulfotransferase 10
709939
Mouse
MGI:2138283
98388
Rat
RGD:621216
140568
Dog
carbohydrate sulfotransferase 10
VGNC:39250
474555
Species
Name
OMA
EggNOG
Inparanoid
Chimp
carbohydrate sulfotransferase 10
Macaque
carbohydrate sulfotransferase 10
Mouse
Rat
Dog
carbohydrate sulfotransferase 10
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O43529-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Metabolism of proteins
Reactome
N-glycan antennae elongation in the medial/trans-Golgi
Reactome
Post-translational protein modification
Reactome
Reactions specific to the complex N-glycan synthesis pathway
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Metabolism of proteins
N-glycan antennae elongation in the medial/trans-Golgi
Post-translational protein modification
Reactions specific to the complex N-glycan synthesis pathway
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (86)
1 – 10 of 86
INSL5
Tbio
Novelty:  0.04351334
p_int:  0.980363939
p_ni:  0.019636033
p_wrong:  2.8e-8
Data Source:  BioPlex
PARL
Tbio
Family:  Enzyme
Novelty:  0.01317944
p_int:  0.973475225
p_ni:  0.026523839
p_wrong:  9.36e-7
Score:  0.203
Data Source:  BioPlex,STRINGDB
PTPRK
Tbio
Family:  Enzyme
Novelty:  0.03149943
p_int:  0.966734046
p_ni:  0.033265951
p_wrong:  3e-9
Score:  0.503
Data Source:  BioPlex,STRINGDB
SCGB2A1
Tbio
Novelty:  0.01902973
p_int:  0.947820476
p_ni:  0.052179524
Data Source:  BioPlex
RLN1
Tbio
Novelty:  0.03992636
p_int:  0.947269803
p_ni:  0.052730189
p_wrong:  8e-9
Data Source:  BioPlex
INS
Tbio
Novelty:  0.00000499
p_int:  0.941505825
p_ni:  0.058492797
p_wrong:  0.000001378
Data Source:  BioPlex
NPTX1
Tbio
Novelty:  0.02872516
p_int:  0.929970221
p_ni:  0.070029749
p_wrong:  2.9e-8
Score:  0.221
Data Source:  BioPlex,STRINGDB
PON2
Tbio
Family:  Enzyme
Novelty:  0.00414855
p_int:  0.927039466
p_ni:  0.072960534
Score:  0.354
Data Source:  BioPlex,STRINGDB
PPM1A
Tchem
Family:  Enzyme
Novelty:  0.01464968
p_int:  0.906011263
p_ni:  0.093900218
p_wrong:  0.00008852
Data Source:  BioPlex
EDDM3B
Tdark
Novelty:  0.12874735
p_int:  0.894556924
p_ni:  0.105442891
p_wrong:  1.85e-7
Data Source:  BioPlex
Publication Statistics
PubMed Score  15.07

PubMed score by year
PubTator Score  12.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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