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Tbio
FOXO3
Forkhead box protein O3

Protein Summary
Description
Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' (PubMed:21329882). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301). This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343882
  • ENSP00000339527
  • ENSG00000118689
  • ENST00000406360
  • ENSP00000385824
  • ENST00000540898
  • ENSP00000446316

Symbol
  • FKHRL1
  • FOXO3A
  • FOXO2
  • AF6q21
  • FKHRL1
  • FOXO3A
  • FKHRL1P2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
kinase
1
hub protein
0.99
biological process
0.98
transcription factor
0.97


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1573.6   (req: < 5)
Gene RIFs: 493   (req: <= 3)
Antibodies: 1051   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1573.6   (req: >= 5)
Gene RIFs: 493   (req: > 3)
Antibodies: 1051   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 51
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
8
14
10
7.2
92.6
IGF-1 measurement
1
2
2
89.5
reticulocyte count
5
4
5
86.3
self reported educational attainment
4
3
3
7.8
86.1
body mass index
7
4
7
82.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
10
7.2
92.6
IGF-1 measurement
2
89.5
reticulocyte count
5
86.3
self reported educational attainment
3
7.8
86.1
body mass index
7
82.5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
forkhead box O3
VGNC:11082
462921
Macaque
forkhead box O3
700731
Mouse
MGI:1890081
56484
Rat
RGD:1309196
294515
Dog
forkhead box O3
VGNC:40963
481954
Species
Name
OMA
EggNOG
Inparanoid
Chimp
forkhead box O3
Macaque
forkhead box O3
Mouse
Rat
Dog
forkhead box O3
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O43524-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (149)
AKT phosphorylates targets in the nucleus (R-HSA-198693)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 33
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AKT phosphorylates targets in the nucleus
Reactome
Constitutive Signaling by AKT1 E17K in Cancer
Reactome
Cytokine Signaling in Immune system
Reactome
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
AKT phosphorylates targets in the nucleus
Constitutive Signaling by AKT1 E17K in Cancer
Cytokine Signaling in Immune system
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Developmental Biology
Gene Ontology Terms (58)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (389)
1 – 10 of 389
SIRT1
Tchem
Family:  Epigenetic
Novelty:  0.00022265
Score:  0.999
Data Source:  Reactome,STRINGDB
AKT1
Tchem
Family:  Kinase
Novelty:  0.00003185
Score:  0.999
Data Source:  Reactome,STRINGDB
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.995
Data Source:  Reactome,STRINGDB
BCL2L11
Tchem
Novelty:  0.00055914
Score:  0.994
Data Source:  STRINGDB
SOD2
Tbio
Family:  Enzyme
Novelty:  0.00084288
Score:  0.994
Data Source:  STRINGDB
SGK1
Tchem
Family:  Kinase
Novelty:  0.00155681
Score:  0.992
Data Source:  STRINGDB
AKT2
Tchem
Family:  Kinase
Novelty:  0.00167027
Score:  0.99
Data Source:  STRINGDB
CREBBP
Tchem
Family:  Epigenetic
Novelty:  0.00111166
Score:  0.988
Data Source:  Reactome,STRINGDB
CDKN1B
Tbio
Family:  Enzyme
Novelty:  0.00069449
Score:  0.987
Data Source:  STRINGDB
SMAD4
Tbio
Family:  TF
Novelty:  0.00047069
Score:  0.985
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  1573.60

PubMed score by year
PubTator Score  848.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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