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Tbio
BCL2L11
Bcl-2-like protein 11

Protein Summary
Description
Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis. The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308659
  • ENSP00000309226
  • ENSG00000153094
  • ENST00000337565
  • ENSP00000338374
  • ENST00000393256
  • ENSP00000376943
  • ENST00000405953
  • ENSP00000384641
  • ENST00000415458
  • ENSP00000393781
  • ENST00000431217
  • ENSP00000394640
  • ENST00000433098
  • ENSP00000401662
  • ENST00000436733
  • ENSP00000403727
  • ENST00000437029
  • ENSP00000412892
  • ENST00000439718
  • ENSP00000411137
  • ENST00000452231
  • ENSP00000391292
  • ENST00000610735
  • ENSP00000481030
  • ENST00000615946
  • ENSP00000481423
  • ENST00000619294
  • ENSP00000479714
  • ENST00000620862
  • ENSP00000478133
  • ENST00000621302
  • ENSP00000481652
  • ENST00000622509
  • ENSP00000482175
  • ENST00000622612
  • ENSP00000484360
  • ENST00000639340
  • ENSP00000491154
  • ENST00000640419
  • ENSP00000491422

Symbol
  • BIM
  • BAM
  • BIM
  • BOD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
microRNA
1
transcription factor perturbation
0.99
kinase
0.98
biological term
0.96


Related Tools
Target Illumination GWAS Analytics (TIGA)
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GENEVA
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1801.88   (req: < 5)
Gene RIFs: 347   (req: <= 3)
Antibodies: 1169   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1801.88   (req: >= 5)
Gene RIFs: 347   (req: > 3)
Antibodies: 1169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 46
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
2
2
2
95.6
2
2
2
86.8
sex hormone-binding globulin measurement
2
1
2
85.5
heel bone mineral density
2
1
2
79
prostate carcinoma
3
3
1
1.1
78.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
2
95.6
2
86.8
sex hormone-binding globulin measurement
2
85.5
heel bone mineral density
2
79
prostate carcinoma
1
1.1
78.5
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
BCL2 like 11 [Source:HGNC Symbol;Acc:HGNC:994]
Mouse
MGI:1197519
12125
Rat
RGD:628774
64547
Dog
BCL2 like 11
612867
Horse
BCL2 like 11
VGNC:49534
100064312
Species
Name
OMA
EggNOG
Inparanoid
Macaque
BCL2 like 11 [Source:HGNC Symbol;Acc:HGNC:994]
Mouse
Rat
Dog
BCL2 like 11
Horse
BCL2 like 11
Protein Structure (37 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O43521-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 37
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (135)
Activation of BH3-only proteins (R-HSA-114452)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of BH3-only proteins
Reactome
Activation of BIM and translocation to mitochondria
Reactome
Apoptosis
Reactome
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Reactome
Cell death signalling via NRAGE, NRIF and NADE
Name
Explore in Pharos
Explore in Source
Activation of BH3-only proteins
Activation of BIM and translocation to mitochondria
Apoptosis
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Cell death signalling via NRAGE, NRIF and NADE
Gene Ontology Terms (54)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (308)
1 – 10 of 308
MCL1
Tchem
Novelty: 0.00046181
p_int: 1
Score: 0.998
Data Source: BioPlex,STRINGDB
BCL2L1
Tchem
Novelty: 0.00018414
p_int: 0.999999936
p_ni: 6.4e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
RHPN2
Tbio
Novelty: 0.04808006
p_int: 0.999998126
p_ni: 9e-9
p_wrong: 0.000001865
Score: 0.224
Data Source: BioPlex,STRINGDB
MTHFR
Tbio
Family: Enzyme
Novelty: 0.00018162
p_int: 0.999353861
p_ni: 0.000646139
Data Source: BioPlex
ZAR1L
Tdark
Novelty: 0.08793345
p_int: 0.998765064
p_ni: 0.001234818
p_wrong: 1.19e-7
Data Source: BioPlex
ANKLE2
Tbio
Novelty: 0.0995907
p_int: 0.998379525
p_ni: 0.001620463
p_wrong: 1.2e-8
Score: 0.186
Data Source: BioPlex,STRINGDB
BCL2
Tclin
Novelty: 0.00608635
p_int: 0.997509561
p_ni: 0.0006702
p_wrong: 0.001820241
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
BCL2L2
Tchem
Novelty: 0.00430896
p_int: 0.99703184
p_ni: 0.00296815
p_wrong: 1e-8
Score: 0.982
Data Source: BioPlex,STRINGDB
EDNRA
Tclin
Family: GPCR
Novelty: 0.00045591
p_int: 0.994878599
p_ni: 0.005121396
p_wrong: 5e-9
Score: 0.553
Data Source: BioPlex,STRINGDB
BTRC
Tbio
Novelty: 0.00293475
p_int: 0.991882568
p_ni: 0.008117396
p_wrong: 3.6e-8
Score: 0.547
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  1801.88

PubMed score by year
PubTator Score  327.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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