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Tbio
ATP8B1
Phospholipid-transporting ATPase IC

Protein Summary
Description
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. May play a role in asymmetric distribution of phospholipids in the canicular membrane. May have a role in transport of bile acids into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa or both. In cooperation with ABCB4 may be involved in establishing integrity of the canalicular membrane thus protecting hepatocytes from bile salts. Together with TMEM30A is involved in uptake of the synthetic drug alkylphospholipid perifosine. Involved in the microvillus formation in polarized epithelial cells; the function seems to be independent from its flippase activity. Required for ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000283684
  • ENSP00000283684
  • ENSG00000081923
  • ENST00000648908
  • ENSP00000497896

Symbol
  • ATPIC
  • FIC1
  • PFIC
  • BRIC
  • FIC1
  • ICP1
  • PFIC
  • ATPIC
  • PFIC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
co-expressed gene
0.99
metabolite
0.98
trait
0.97
protein domain
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 135.06   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 38   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 135.06   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 38   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
1
1
82.5
hematocrit
2
2
2
75.9
hemoglobin measurement
2
2
2
74.4
red blood cell density measurement
1
1
1
67.3
serum gamma-glutamyl transferase measurement
1
1
0
4.8
39.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
82.5
hematocrit
2
75.9
hemoglobin measurement
2
74.4
red blood cell density measurement
1
67.3
serum gamma-glutamyl transferase measurement
0
4.8
39.1
Pathways (3)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Ion transport by P-type ATPases
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Ion transport by P-type ATPases
Transport of small molecules
Gene Ontology Terms (17)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (76)
1 – 10 of 76
TMEM30A
Tbio
Novelty: 0.05115559
Score: 0.92
Data Source: STRINGDB
ABCB11
Tchem
Family: Transporter
Novelty: 0.00097529
Score: 0.911
Data Source: STRINGDB
ABCB4
Tbio
Family: Transporter
Novelty: 0.00080254
Score: 0.8
Data Source: STRINGDB
TMEM30B
Tbio
Novelty: 0.26735006
Score: 0.776
Data Source: STRINGDB
GGT1
Tbio
Family: Enzyme
Novelty: 0.00252374
Score: 0.741
Data Source: STRINGDB
CUL3
Tbio
Novelty: 0.0028737
Score: 0.731
Data Source: STRINGDB
BACH2
Tbio
Family: TF
Novelty: 0.00932069
Score: 0.714
Data Source: STRINGDB
HSD3B7
Tbio
Family: Enzyme
Novelty: 0.04791842
Score: 0.653
Data Source: STRINGDB
RCBTB2
Tbio
Novelty: 0.04244536
Score: 0.652
Data Source: STRINGDB
MAFK
Tbio
Family: TF
Novelty: 0.01735942
Score: 0.642
Data Source: STRINGDB
Publication Statistics
PubMed Score  135.06

PubMed score by year
PubTator Score  214.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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