Tbio ATP8B1 Phospholipid-transporting ATPase IC

Protein Summary

Description

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. May play a role in asymmetric distribution of phospholipids in the canicular membrane. May have a role in transport of bile acids into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa or both. In cooperation with ABCB4 may be involved in establishing integrity of the canalicular membrane thus protecting hepatocytes from bile salts. Together with TMEM30A is involved in uptake of the synthetic drug alkylphospholipid perifosine. Involved in the microvillus formation in polarized epithelial cells; the function seems to be independent from its flippase activity. Required for the preservation of cochlear hair cells in the inner ear. May act as cardiolipin transporter during inflammatory injury. This gene encodes a member of the P-type cation transport ATPase family, which belongs to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. Mutations in this gene may result in progressive familial intrahepatic cholestasis type 1 and in benign recurrent intrahepatic cholestasis. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O43520
• Q9BTP8

Gene Name

• ATP8B1

Ensembl ID

• ENST00000283684
• ENSP00000283684
• ENSG00000081923
• ENST00000648908
• ENSP00000497896

Symbol

• ATPIC
• FIC1
• PFIC
• BRIC
• FIC1
• ICP1
• PFIC
• ATPIC
• PFIC1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
co-expressed gene	0.99
metabolite	0.98
trait	0.97
protein domain	0.92

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Phospholipid-transporting Atpase Ic

Protein / Hydrolase / Phospholipid-transporting Atpase Ic

DTO Classes

Protein / Transporter / P-type Atpases / Phospholipid-transporting Atpases / Phospholipid-transporting Atpase Ic

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 171.23   (req: < 5)

Gene RIFs: 54   (req: <= 3)

Antibodies: 38   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 171.23   (req: >= 5)

Gene RIFs: 54   (req: > 3)

Antibodies: 38   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0