Tbio WIPF1 WAS/WASL-interacting protein family member 1

Protein Summary

Description

Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus. This gene encodes a protein that plays an important role in the organization of the actin cytoskeleton. The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive disorder. Impairment of the interaction between these two proteins may contribute to the disease. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O43516
• B8ZZM1
• D3DPE4
• Q15220
• Q53TA9
• Q6MZU9
• Q9BU37
• Q9UNP1

Gene Name

• WIPF1

Ensembl ID

• ENST00000272746
• ENSP00000272746
• ENSG00000115935
• ENST00000359761
• ENSP00000352802
• ENST00000392546
• ENSP00000376329
• ENST00000392547
• ENSP00000376330
• ENST00000409891
• ENSP00000386431

Symbol

• WASPIP
• WIP
• WIP
• WAS2
• PRPL-2
• WASPIP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.91
kinase perturbation	0.88
gene perturbation	0.86
disease perturbation	0.83
cell type or tissue	0.8

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 320.87   (req: < 5)

Gene RIFs: 31   (req: <= 3)

Antibodies: 138   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 320.87   (req: >= 5)

Gene RIFs: 31   (req: > 3)

Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0