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Tbio
SLC26A4
Pendrin

Protein Summary
Description
Sodium-independent transporter of chloride and iodide. Mutations in this gene are associated with Pendred syndrome, the most common form of syndromic deafness, an autosomal-recessive disease. It is highly homologous to the SLC26A3 gene; they have similar genomic structures and this gene is located 3' of the SLC26A3 gene. The encoded protein has homology to sulfate transporters. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265715
  • ENSP00000265715
  • ENSG00000091137
  • ENST00000644269
  • ENSP00000494017

Symbol
  • PDS
  • EVA
  • PDS
  • DFNB4
  • TDH2B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.88
protein domain
0.85
PubMedID
0.7
co-expressed gene
0.65
histone modification site profile
0.63


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 689.58   (req: < 5)
Gene RIFs: 217   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 689.58   (req: >= 5)
Gene RIFs: 217   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
5
3
1.1
57.7
lymphocyte count
2
2
2
51.7
alkaline phosphatase measurement
1
1
1
21.5
cortical surface area measurement
1
1
0
10.7
17.8
sleep duration
1
1
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.1
57.7
lymphocyte count
2
51.7
alkaline phosphatase measurement
1
21.5
cortical surface area measurement
0
10.7
17.8
sleep duration
1
14.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 26 member 4
VGNC:8761
463654
Macaque
solute carrier family 26 member 4
699859
Mouse
MGI:1346029
23985
Rat
RGD:3293
29440
Dog
solute carrier family 26 member 4
VGNC:46324
483263
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 26 member 4
Macaque
solute carrier family 26 member 4
Mouse
Rat
Dog
solute carrier family 26 member 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O43511-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Defective SLC26A4 causes Pendred syndrome (PDS) (R-HSA-5619046)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective SLC26A4 causes Pendred syndrome (PDS)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
Multifunctional anion exchangers
Reactome
SLC transporter disorders
Name
Explore in Pharos
Explore in Source
Defective SLC26A4 causes Pendred syndrome (PDS)
Disease
Disorders of transmembrane transporters
Multifunctional anion exchangers
SLC transporter disorders
Gene Ontology Terms (19)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (114)
1 – 10 of 114
GJB2
Tbio
Novelty:  0.00056398
Score:  0.899
Data Source:  STRINGDB
FOXI1
Tbio
Family:  TF
Novelty:  0.02247223
Score:  0.857
Data Source:  STRINGDB
ATP6V1B1
Tchem
Family:  Enzyme
Novelty:  0.01122589
Score:  0.837
Data Source:  STRINGDB
GJB3
Tbio
Novelty:  0.00612314
Score:  0.791
Data Source:  STRINGDB
SLC4A4
Tbio
Family:  Transporter
Novelty:  0.00352439
Score:  0.779
Data Source:  STRINGDB
TMPRSS3
Tbio
Family:  Enzyme
Novelty:  0.0268524
Score:  0.777
Data Source:  STRINGDB
MYO15A
Tbio
Novelty:  0.0148787
Score:  0.752
Data Source:  STRINGDB
TMC1
Tbio
Family:  IC
Novelty:  0.00609628
Score:  0.745
Data Source:  STRINGDB
OTOF
Tbio
Novelty:  0.00676341
Score:  0.743
Data Source:  STRINGDB
SLC5A5
Tbio
Family:  Transporter
Novelty:  0.00139132
Score:  0.732
Data Source:  STRINGDB
Publication Statistics
PubMed Score  689.58

PubMed score by year
PubTator Score  519.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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