You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TNFSF12
Tumor necrosis factor ligand superfamily member 12

Protein Summary
Description
Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion. This gene encodes a member of the tumor necrosis factor superfamily. It encodes a hybrid protein composed of the cytoplasmic and transmembrane domains of family member 12 fused to the C-terminal domain of family member 13. The hybrid protein is membrane anchored and presents the receptor-binding domain of family member 13 at the cell surface. It stimulates cycling in T- and B-lymphoma cell lines. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293825
  • ENSP00000293825
  • ENSG00000239697

Symbol
  • APO3L
  • DR3LG
  • TWE-PRIL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.89
ligand (protein) perturbation
0.83
histone modification site profile
0.76
tissue sample
0.75
disease perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 387.14   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 512   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 387.14   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 512   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (51)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
10
26
37
100
sex hormone-binding globulin measurement
8
7
20
99.6
serum non-albumin protein measurement
3
7
9
99
blood protein measurement
2
6
6
97.3
albumin:globulin ratio measurement
1
2
2
94.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
37
100
sex hormone-binding globulin measurement
20
99.6
serum non-albumin protein measurement
9
99
blood protein measurement
6
97.3
albumin:globulin ratio measurement
2
94.1
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TNF superfamily member 12
VGNC:14220
100551503
Mouse
MGI:1196259
21944
Opossum
TNF superfamily member 12
100551511
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TNF superfamily member 12
Mouse
Opossum
TNF superfamily member 12
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O43508-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Reactome
TNFR2 non-canonical NF-kB pathway
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
TNFR2 non-canonical NF-kB pathway
Protein-Protein Interactions (104)
1 – 10 of 104
TNFRSF12A
Tbio
Novelty:  0.00550274
Score:  0.995
Data Source:  Reactome,STRINGDB
TNFRSF25
Tbio
Novelty:  0.0005039
Score:  0.981
Data Source:  STRINGDB
TNFSF13B
Tclin
Novelty:  0.00069885
Score:  0.979
Data Source:  STRINGDB
TNFSF11
Tclin
Novelty:  0.00018328
Score:  0.968
Data Source:  STRINGDB
BIRC2
Tchem
Novelty:  0.00199701
Score:  0.963
Data Source:  Reactome,STRINGDB
TRAF2
Tbio
Novelty:  0.00983658
Score:  0.96
Data Source:  Reactome,STRINGDB
TNF
Tclin
Novelty:  0.00001457
Score:  0.96
Data Source:  STRINGDB
TNFRSF1B
Tbio
Novelty:  0.0013033
Score:  0.944
Data Source:  STRINGDB
CASP8
Tchem
Family:  Enzyme
Novelty:  0.00024321
Score:  0.942
Data Source:  STRINGDB
TRADD
Tbio
Novelty:  0.00560091
Score:  0.941
Data Source:  STRINGDB
Publication Statistics
PubMed Score  387.14

PubMed score by year
PubTator Score  4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: