You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
B4GAT1
Beta-1,4-glucuronyltransferase 1

Protein Summary
Description
Beta-1,4-glucuronyltransferase involved in O-mannosylation of alpha-dystroglycan (DAG1). Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor to produce the glucuronyl-beta-1,4-xylose-beta disaccharide primer, which is further elongated by LARGE1, during synthesis of phosphorylated O-mannosyl glycan (PubMed:25279699, PubMed:25279697). Phosphorylated O-mannosyl glycan is a carbohydrate is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:25279699, PubMed:25279697). Required for axon guidance; via its function in O-mannosylation of alpha-dystroglycan (DAG1) (By similarity). This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein. It is essential for the synthesis of poly-N-acetyllactosamine, a determinant for the blood group i antigen. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311181
  • ENSP00000309096
  • ENSG00000174684

Symbol
  • B3GNT1
  • B3GNT6
  • iGAT
  • iGNT
  • B3GNT1
  • B3GNT6
  • B3GN-T1
  • MDDGA13
  • BETA3GNTI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.28   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 123   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.28   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 123   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (133)
PTPN2
Tchem
Family:  Enzyme
Novelty:  0.00372891
p_int:  0.999987921
p_ni:  0.000012078
p_wrong:  1e-9
Score:  0.151
Data Source:  BioPlex,STRINGDB
ATP9A
Tbio
Family:  Transporter
Novelty:  0.15755352
p_int:  0.999485528
p_ni:  0.000514463
p_wrong:  1e-8
Data Source:  BioPlex
SNX25
Tbio
Novelty:  0.15818269
p_int:  0.999360865
p_ni:  0.000636282
p_wrong:  0.000002853
Score:  0.199
Data Source:  BioPlex,STRINGDB
EIF2AK3
Tchem
Family:  Kinase
Novelty:  0.00044559
p_int:  0.998825765
p_ni:  0.001174234
Data Source:  BioPlex
SUSD1
Tdark
Novelty:  0.54249826
p_int:  0.998685955
p_ni:  0.001313918
p_wrong:  1.26e-7
Score:  0.19
Data Source:  BioPlex,STRINGDB
ADCY6
Tchem
Family:  Enzyme
Novelty:  0.00528765
p_int:  0.99816879
p_ni:  0.00183121
Data Source:  BioPlex
FKTN
Tbio
Novelty:  0.00981221
p_int:  0.996995565
p_ni:  0.002887084
p_wrong:  0.000117351
Score:  0.679
Data Source:  BioPlex,STRINGDB
PPM1L
Tbio
Family:  Enzyme
Novelty:  0.09146774
p_int:  0.994475793
p_ni:  0.00306622
p_wrong:  0.002457987
Score:  0.214
Data Source:  BioPlex,STRINGDB
ST7
Tbio
Novelty:  0.0339662
p_int:  0.992463093
p_ni:  0.007536907
Data Source:  BioPlex
TMEM39A
Tbio
Novelty:  0.11657639
p_int:  0.992182656
p_ni:  0.007817344
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
Defective LARGE causes MDDGA6 and MDDGB6 (R-HSA-5083627)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective LARGE causes MDDGA6 and MDDGB6
Reactome
Disease
Reactome
Diseases associated with O-glycosylation of proteins
Reactome
Diseases of glycosylation
Reactome
Glycosaminoglycan metabolism
Name
Explore in Pharos
Explore in Source
Defective LARGE causes MDDGA6 and MDDGB6
Disease
Diseases associated with O-glycosylation of proteins
Diseases of glycosylation
Glycosaminoglycan metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
2
2
3
80.7
self reported educational attainment
3
2
3
80.4
educational attainment
1
2
2
68.5
BMI-adjusted waist circumference
2
3
4
64.4
insomnia measurement
1
2
0
1
57.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
3
80.7
self reported educational attainment
3
80.4
educational attainment
2
68.5
BMI-adjusted waist circumference
4
64.4
insomnia measurement
0
1
57.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
beta-1,4-glucuronyltransferase 1
VGNC:7795
451344
Macaque
beta-1,4-glucuronyltransferase 1
714270
Mouse
MGI:1919680
108902
Dog
beta-1,4-glucuronyltransferase 1
VGNC:38355
476013
Horse
beta-1,4-glucuronyltransferase 1
VGNC:15746
100058396
Species
Name
OMA
EggNOG
Inparanoid
Chimp
beta-1,4-glucuronyltransferase 1
Macaque
beta-1,4-glucuronyltransferase 1
Mouse
Dog
beta-1,4-glucuronyltransferase 1
Horse
beta-1,4-glucuronyltransferase 1
Publication Statistics
PubMed Score 23.28
PubMed score by year
PubTator Score 10.22
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title