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Tbio
B4GAT1
Beta-1,4-glucuronyltransferase 1

Protein Summary
Description
Beta-1,4-glucuronyltransferase involved in O-mannosylation of alpha-dystroglycan (DAG1). Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor to produce the glucuronyl-beta-1,4-xylose-beta disaccharide primer, which is further elongated by LARGE1, during synthesis of phosphorylated O-mannosyl glycan (PubMed:25279699, PubMed:25279697). Phosphorylated O-mannosyl glycan is a carbohydrate is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:25279699, PubMed:25279697). Required for axon guidance; via its function in O-mannosylation of alpha-dystroglycan (DAG1) (By similarity). This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein. It is essential for the synthesis of poly-N-acetyllactosamine, a determinant for the blood group i antigen. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311181
  • ENSP00000309096
  • ENSG00000174684

Symbol
  • B3GNT1
  • B3GNT6
  • iGAT
  • iGNT
  • B3GNT1
  • B3GNT6
  • B3GN-T1
  • MDDGA13
  • BETA3GNTI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.42   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 123   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.42   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 123   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (15)
Defective LARGE causes MDDGA6 and MDDGB6 (R-HSA-5083627)

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Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective LARGE causes MDDGA6 and MDDGB6
Reactome
Disease
Reactome
Diseases associated with O-glycosylation of proteins
Reactome
Diseases of glycosylation
Reactome
Glycosaminoglycan metabolism
Name
Explore in Pharos
Explore in Source
Defective LARGE causes MDDGA6 and MDDGB6
Disease
Diseases associated with O-glycosylation of proteins
Diseases of glycosylation
Glycosaminoglycan metabolism
Protein-Protein Interactions (133)
1 – 10 of 133
PTPN2
Tchem
Family: Enzyme
Novelty: 0.00214939
p_int: 0.999987921
p_ni: 0.000012078
p_wrong: 1e-9
Score: 0.151
Data Source: BioPlex,STRINGDB
ATP9A
Tbio
Family: Transporter
Novelty: 0.30295744
p_int: 0.999485528
p_ni: 0.000514463
p_wrong: 1e-8
Data Source: BioPlex
SNX25
Tbio
Novelty: 0.34710744
p_int: 0.999360865
p_ni: 0.000636282
p_wrong: 0.000002853
Score: 0.199
Data Source: BioPlex,STRINGDB
EIF2AK3
Tchem
Family: Kinase
Novelty: 0.00059307
p_int: 0.998825765
p_ni: 0.001174234
Data Source: BioPlex
SUSD1
Tdark
Novelty: 2.91666667
p_int: 0.998685955
p_ni: 0.001313918
p_wrong: 1.26e-7
Score: 0.19
Data Source: BioPlex,STRINGDB
ADCY6
Tchem
Family: Enzyme
Novelty: 0.0060511
p_int: 0.99816879
p_ni: 0.00183121
Data Source: BioPlex
FKTN
Tbio
Novelty: 0.00450349
p_int: 0.996995565
p_ni: 0.002887084
p_wrong: 0.000117351
Score: 0.679
Data Source: BioPlex,STRINGDB
PPM1L
Tbio
Family: Enzyme
Novelty: 0.17709194
p_int: 0.994475793
p_ni: 0.00306622
p_wrong: 0.002457987
Score: 0.214
Data Source: BioPlex,STRINGDB
ST7
Tbio
Novelty: 0.03189752
p_int: 0.992463093
p_ni: 0.007536907
Data Source: BioPlex
TMEM39A
Tbio
Novelty: 0.17017828
p_int: 0.992182656
p_ni: 0.007817344
Data Source: BioPlex
Publication Statistics
PubMed Score  17.42

PubMed score by year
PubTator Score  10.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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