Tbio RAD51C DNA repair protein RAD51 homolog 3

Protein Summary

Description

Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Part of the RAD21 paralog protein complexes BCDX2 and CX3 which act at different stages of the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 seems to act downstream of BRCA2 recruitment and upstream of RAD51 recruitment; CX3 seems to act downstream of RAD51 recruitment; both complexes bind predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. Involved in RAD51 foci formation in response to DNA damage suggesting an involvement in early stages of HR probably in the invasion step. Has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinase CHEK2 and thereby transduction of the damage signal, leading to cell cycle arrest and HR activation. Participates in branch migration and HJ resolution and thus is important for processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex. Part of a PALB2-scaffolded HR complex containing BRCA2 and which is thought to play a role in DNA repair by HR. Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA damage. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and XRCC3. Contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Involved in maintaining centrosome number in mitosis. This gene is a member of the RAD51 family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51 and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with other RAD51 paralogs and is reported to be important for Holliday junction resolution. Mutations in this gene are associated with Fanconi anemia-like syndrome. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• O43502
• O43503
• Q3B783
• R51H3

Gene Name

• RAD51C

Ensembl ID

• ENST00000337432
• ENSP00000336701
• ENSG00000108384
• ENST00000421782
• ENSP00000391450

Symbol

• RAD51L2
• FANCO
• R51H3
• BROVCA3
• RAD51L2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
histone modification site profile	0.89
kinase perturbation	0.88
transcription factor binding site profile	0.81
protein domain	0.73

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.96   (req: < 5)

Gene RIFs: 61   (req: <= 3)

Antibodies: 352   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.96   (req: >= 5)

Gene RIFs: 61   (req: > 3)

Antibodies: 352   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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ARCHS4

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (217)

Explore Interacting Targets

1 – 10 of 217

• See Interactions on String-DB

KLHL10

Tdark

Novelty:  0.09497583

p_int:  0.999996895

p_ni:  0.000003105

Score:  0.167

Data Source:  BioPlex,STRINGDB

PTPN9

Tchem

Family:  Enzyme

Novelty:  0.01574113

p_int:  0.999060315

p_ni:  0.000939685

Score:  0.188

Data Source:  BioPlex,STRINGDB

XRCC2

Tbio

Novelty:  0.00862049

p_int:  0.994666946

p_ni:  0.005333054

Score:  0.98

Data Source:  BioPlex,Reactome,STRINGDB

CCDC140

Tdark

Novelty:  2.54113496

p_int:  0.988756179

p_ni:  0.001419398

p_wrong:  0.009824423

Score:  0.282

Data Source:  BioPlex,STRINGDB

SPACA1

Tbio

Novelty:  0.07415851

p_int:  0.918267139

p_ni:  0.081732861

Data Source:  BioPlex

EFNB3

Tbio

Novelty:  0.0120367

p_int:  0.88732406

p_ni:  0.11267594

Data Source:  BioPlex

DKKL1

Tbio

Novelty:  0.00544618

p_int:  0.801493754

p_ni:  0.198506246

Data Source:  BioPlex

FAM174A

Tdark

Novelty:  0.30693139

p_int:  0.778536285

p_ni:  0.221463715

Data Source:  BioPlex

ADAMTS4

Tchem

Family:  Enzyme

Novelty:  0.00424194

p_int:  0.761509157

p_ni:  0.238490843

Data Source:  BioPlex

HENMT1

Tdark

Family:  Enzyme

Novelty:  0.17427834

p_int:  0.756103317

p_ni:  0.243896683

Score:  0.228

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (18)

Reactome (16)

KEGG (2)

Cell Cycle (R-HSA-1640170)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	DNA Double-Strand Break Repair	146 targets	R-HSA-5693532
Reactome	DNA Repair	306 targets	R-HSA-73894
Reactome	Factors involved in megakaryocyte development and platelet production	139 targets	R-HSA-983231
Reactome	HDR through Homologous Recombination (HRR)	66 targets	R-HSA-5685942

Name	Explore in Pharos	Explore in Source
Cell Cycle	597 targets	R-HSA-1640170
DNA Double-Strand Break Repair	146 targets	R-HSA-5693532
DNA Repair	306 targets	R-HSA-73894
Factors involved in megakaryocyte development and platelet production	139 targets	R-HSA-983231
HDR through Homologous Recombination (HRR)	66 targets	R-HSA-5685942

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (26)

Functions (4)

Components (11)

Processes (11)

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1 – 4 of 4

GO Term	Evidence	Assigned by
DNA binding	Traceable Author Statement (TAS)	ProtInc
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
crossover junction endodeoxyribonuclease activity	Inferred from Electronic Annotation (IEA)	Ensembl
DNA-dependent ATPase activity	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (12)

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1 – 5 of 12

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
neutrophil count	EFO_0004833	1	1	1		64.9
systolic blood pressure	EFO_0006335	1	1	1		63.7
glomerular filtration rate	EFO_0005208	2	1	2		44.2
urate measurement	EFO_0004531	1	1	1		42.3
iron biomarker measurement	EFO_0004461	1	1	1		42.3

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
neutrophil count	EFO_0004833	1		64.9
systolic blood pressure	EFO_0006335	1		63.7
glomerular filtration rate	EFO_0005208	2		44.2
urate measurement	EFO_0004531	1		42.3
iron biomarker measurement	EFO_0004461	1		42.3

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
ATP-binding
Complete proteome
Cytoplasm
Disease mutation
DNA damage
DNA recombination
DNA repair
DNA-binding
Fanconi anemia

GWAS Trait Find Similar Targets

No Header	No Header
cognitive function measurement
ferritin measurement
glomerular filtration rate
intelligence
iron biomarker measurement
leukocyte count
neutrophil count
self reported educational attainment
systolic blood pressure
tooth eruption

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
embryo phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
mortality/aging
reproductive system phenotype

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	RAD51 paralog C	VGNC:9552	455162
Macaque	RAD51 paralog C		714828
Mouse	RAD51 paralog C	MGI:2150020	114714
Rat	RAD51 paralog C	RGD:1563765	497976
Dog	RAD51 paralog C	VGNC:45319	480573

Species	Name	OMA	EggNOG	Inparanoid
Chimp	RAD51 paralog C
Macaque	RAD51 paralog C
Mouse	RAD51 paralog C
Rat	RAD51 paralog C
Dog	RAD51 paralog C

Publication Statistics

PubMed Score 142.96

PubMed score by year

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PubTator Score 99.02

PubTator score by year

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Related Publications

Text Mined References (94)

GeneRif Annotations (61)

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PMID	Year	Title