TGOLN2
Trans-Golgi network integral membrane protein 2
Protein Summary
May be involved in regulating membrane traffic to and from trans-Golgi network. This gene encodes a type I integral membrane protein that is localized to the trans-Golgi network, a major sorting station for secretory and membrane proteins. The encoded protein cycles between early endosomes and the trans-Golgi network, and may play a role in exocytic vesicle formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
- ENST00000282120
- ENSP00000282120
- ENSG00000152291
- ENST00000377386
- ENSP00000366603
- ENST00000398263
- ENSP00000381312
- ENST00000409232
- ENSP00000386443
- ENST00000444342
- ENSP00000391190
- TGN46
- TGN51
- TGN38
- TGN46
- TGN48
- TGN51
- TTGN2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.99 | ||
virus perturbation | 0.99 | ||
disease perturbation | 0.96 | ||
transcription factor perturbation | 0.84 | ||
microRNA | 0.77 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 172.36 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 295 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 172.36 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 295 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0