You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TGOLN2
Trans-Golgi network integral membrane protein 2

Protein Summary
Description
May be involved in regulating membrane traffic to and from trans-Golgi network. This gene encodes a type I integral membrane protein that is localized to the trans-Golgi network, a major sorting station for secretory and membrane proteins. The encoded protein cycles between early endosomes and the trans-Golgi network, and may play a role in exocytic vesicle formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282120
  • ENSP00000282120
  • ENSG00000152291
  • ENST00000377386
  • ENSP00000366603
  • ENST00000398263
  • ENSP00000381312
  • ENST00000409232
  • ENSP00000386443
  • ENST00000444342
  • ENSP00000391190

Symbol
  • TGN46
  • TGN51
  • TGN38
  • TGN46
  • TGN48
  • TGN51
  • TTGN2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
virus perturbation
0.99
disease perturbation
0.96
transcription factor perturbation
0.84
microRNA
0.77


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.25   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 295   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.25   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 295   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (386)
ALG2
Tbio
Family:  Enzyme
Novelty:  0.03804805
p_int:  0.999908886
p_ni:  0.000078174
p_wrong:  0.000012939
Score:  0.196
Data Source:  BioPlex,STRINGDB
ARF6
Tbio
Family:  Enzyme
Novelty:  0.00278138
p_int:  0.999302841
p_ni:  0.000697159
Score:  0.46
Data Source:  BioPlex,STRINGDB
DOCK5
Tbio
Novelty:  0.03153692
p_int:  0.999099647
p_ni:  0.000226705
p_wrong:  0.000673648
Score:  0.152
Data Source:  BioPlex,STRINGDB
GOPC
Tbio
Novelty:  0.01110168
p_int:  0.998112428
p_ni:  0.001887572
Score:  0.28
Data Source:  BioPlex,STRINGDB
INTS4
Tdark
Novelty:  0.20868831
p_int:  0.988689216
p_ni:  0.011310784
Data Source:  BioPlex
IPO13
Tbio
Novelty:  0.01954093
p_int:  0.977423145
p_ni:  0.022576855
Data Source:  BioPlex
GPD1L
Tbio
Family:  Enzyme
Novelty:  0.0169606
p_int:  0.976279938
p_ni:  0.023720062
Data Source:  BioPlex
GGH
Tchem
Family:  Enzyme
Novelty:  0.00258239
p_int:  0.965242361
p_ni:  0.034757639
Data Source:  BioPlex
RRAGB
Tbio
Novelty:  0.02279777
p_int:  0.964344134
p_ni:  0.035655722
p_wrong:  1.44e-7
Data Source:  BioPlex
RUFY1
Tbio
Novelty:  0.16796947
p_int:  0.957543272
p_ni:  0.042281589
p_wrong:  0.000175139
Score:  0.284
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Golgi Associated Vesicle Biogenesis
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Membrane Trafficking
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Golgi Associated Vesicle Biogenesis
Intra-Golgi and retrograde Golgi-to-ER traffic
Membrane Trafficking
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
1
2
77.6
platelet count
1
1
1
68.8
heel bone mineral density
2
2
2
68.5
high density lipoprotein cholesterol measurement
2
2
3
59.7
bone density
1
2
2
39.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
77.6
platelet count
1
68.8
heel bone mineral density
2
68.5
high density lipoprotein cholesterol measurement
3
59.7
bone density
2
39.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
trans-golgi network protein 2
VGNC:487
470418
Macaque
trans-golgi network protein 2
100426141
Mouse
MGI:105080
22134
Rat
RGD:620445
192152
Dog
trans-golgi network protein 2
475772
Species
Name
OMA
EggNOG
Inparanoid
Chimp
trans-golgi network protein 2
Macaque
trans-golgi network protein 2
Mouse
Rat
Dog
trans-golgi network protein 2
Publication Statistics
PubMed Score 158.25
PubMed score by year
PubTator Score 94.15
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title