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Tbio
EPB41L2
Band 4.1-like protein 2

Protein Summary
Description
Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337057
  • ENSP00000338481
  • ENSG00000079819
  • ENST00000368128
  • ENSP00000357110
  • ENST00000392427
  • ENSP00000376222
  • ENST00000445890
  • ENSP00000402041
  • ENST00000525271
  • ENSP00000432803
  • ENST00000528282
  • ENSP00000434308
  • ENST00000530481
  • ENSP00000434576

Symbol
  • 4.1G
  • 4.1-G
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
protein domain
1
transcription factor perturbation
0.91
disease perturbation
0.9
hub protein
0.9


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.76   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 222   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.76   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 222   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
3
6
97.2
balding measurement
1
1
1
86.9
urolithiasis
1
1
0
1.1
49.6
mean corpuscular volume
1
1
1
48.4
loneliness measurement
3
1
3
48.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
6
97.2
balding measurement
1
86.9
urolithiasis
0
1.1
49.6
mean corpuscular volume
1
48.4
loneliness measurement
3
48.3
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
erythrocyte membrane protein band 4.1 like 2
VGNC:9540
462997
Macaque
erythrocyte membrane protein band 4.1 like 2
714889
Mouse
MGI:103009
13822
Rat
RGD:1563977
309557
Dog
erythrocyte membrane protein band 4.1 like 2
VGNC:40394
484127
Species
Name
OMA
EggNOG
Inparanoid
Chimp
erythrocyte membrane protein band 4.1 like 2
Macaque
erythrocyte membrane protein band 4.1 like 2
Mouse
Rat
Dog
erythrocyte membrane protein band 4.1 like 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O43491-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Neurexins and neuroligins (R-HSA-6794361)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neurexins and neuroligins
Reactome
Neuronal System
Reactome
Protein-protein interactions at synapses
Name
Explore in Pharos
Explore in Source
Neurexins and neuroligins
Neuronal System
Protein-protein interactions at synapses
Gene Ontology Terms (18)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (75)
1 – 10 of 75
MLLT1
Tbio
Novelty: 0.00328241
p_int: 0.999998265
p_ni: 0.000001368
p_wrong: 3.67e-7
Data Source: BioPlex
MLLT3
Tbio
Novelty: 0.00361056
p_int: 0.999996319
p_ni: 0.000003681
Data Source: BioPlex
RNPS1
Tbio
Novelty: 0.03203224
p_int: 0.999992959
p_ni: 0.000007041
Score: 0.307
Data Source: BioPlex,STRINGDB
PNN
Tbio
Novelty: 0.01395394
p_int: 0.999991935
p_ni: 0.000008065
Score: 0.203
Data Source: BioPlex,STRINGDB
ACIN1
Tbio
Novelty: 0.01675479
p_int: 0.999973553
p_ni: 0.000026447
Score: 0.158
Data Source: BioPlex,STRINGDB
GPATCH8
Tdark
Novelty: 0.45717416
p_int: 0.999962972
p_ni: 0.000037028
Data Source: BioPlex
CWC22
Tbio
Novelty: 0.027689
p_int: 0.999962469
p_ni: 0.00003753
Data Source: BioPlex
DDAH2
Tbio
Family: Enzyme
Novelty: 0.00355931
p_int: 0.999660381
p_ni: 0.000339619
Score: 0.747
Data Source: BioPlex,STRINGDB
WDR59
Tdark
Novelty: 0.22243351
p_int: 0.996858474
p_ni: 0.003141526
Data Source: BioPlex
EPB41L3
Tbio
Novelty: 0.00915217
p_int: 0.996133832
p_ni: 0.003866168
Score: 0.98
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  34.76

PubMed score by year
PubTator Score  31.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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