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Tbio
PROM1
Prominin-1

Protein Summary
Description
May play a role in cell differentiation, proliferation and apoptosis (PubMed:24556617). Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner (PubMed:20818439). This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters th ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000447510
  • ENSP00000415481
  • ENSG00000007062
  • ENST00000505450
  • ENSP00000426090
  • ENST00000508167
  • ENSP00000427346
  • ENST00000510224
  • ENSP00000426809
  • ENST00000539194
  • ENSP00000443620
  • ENST00000540805
  • ENSP00000438045

Symbol
  • PROML1
  • RP41
  • AC133
  • CD133
  • MCDR2
  • STGD4
  • CORD12
  • PROML1
  • MSTP061
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
PubMedID
0.99
trait
0.75
disease
0.74
transcription factor perturbation
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2993.93   (req: < 5)
Gene RIFs: 475   (req: <= 3)
Antibodies: 482   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2993.93   (req: >= 5)
Gene RIFs: 475   (req: > 3)
Antibodies: 482   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
1
1
37.4
electrocardiography
1
1
4
20.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
37.4
electrocardiography
4
20.5
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
prominin 1
VGNC:665
461127
Macaque
prominin 1
714610
Mouse
MGI:1100886
19126
Rat
RGD:69367
60357
Dog
prominin 1
VGNC:45012
488816
Species
Name
OMA
EggNOG
Inparanoid
Chimp
prominin 1
Macaque
prominin 1
Mouse
Rat
Dog
prominin 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O43490-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (25)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (233)
1 – 10 of 233
CD34
Tbio
Novelty: 0.00005468
Score: 0.938
Data Source: STRINGDB
CDHR1
Tbio
Novelty: 0.03000456
Score: 0.934
Data Source: STRINGDB
POU5F1
Tbio
Family: TF
Novelty: 0.00033974
Score: 0.919
Data Source: STRINGDB
CD44
Tbio
Novelty: 0.00011321
Score: 0.896
Data Source: STRINGDB
THY1
Tbio
Novelty: 0.00032846
Score: 0.889
Data Source: STRINGDB
SOX2
Tbio
Family: TF
Novelty: 0.00037089
Score: 0.889
Data Source: STRINGDB
NANOG
Tbio
Family: TF
Novelty: 0.00054893
Score: 0.88
Data Source: STRINGDB
CD24
Tbio
Novelty: 0.00097222
Score: 0.86
Data Source: STRINGDB
NES
Tbio
Novelty: 0.00035379
Score: 0.854
Data Source: STRINGDB
EGF
Tbio
Novelty: 0.00010809
Score: 0.852
Data Source: STRINGDB
Publication Statistics
PubMed Score  2993.93

PubMed score by year
PubTator Score  2012.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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