You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PROM1
Prominin-1

Protein Summary
Description
May play a role in cell differentiation, proliferation and apoptosis (PubMed:24556617). Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner (PubMed:20818439). This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters th ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000447510
  • ENSP00000415481
  • ENSG00000007062
  • ENST00000505450
  • ENSP00000426090
  • ENST00000508167
  • ENSP00000427346
  • ENST00000510224
  • ENSP00000426809
  • ENST00000539194
  • ENSP00000443620
  • ENST00000540805
  • ENSP00000438045

Symbol
  • PROML1
  • RP41
  • AC133
  • CD133
  • MCDR2
  • STGD4
  • CORD12
  • PROML1
  • MSTP061
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
PubMedID
0.99
trait
0.75
disease
0.74
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3323.4   (req: < 5)
Gene RIFs: 581   (req: <= 3)
Antibodies: 482   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3323.4   (req: >= 5)
Gene RIFs: 581   (req: > 3)
Antibodies: 482   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0