AKR7A2
Aflatoxin B1 aldehyde reductase member 2
Protein Summary
Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction o ...more
- ENST00000235835
- ENSP00000235835
- ENSG00000053371
- AFAR
- AFAR1
- AKR7
- AFAR
- AKR7
- AFAR1
- AFB1-AR1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.93 | ||
virus perturbation | 0.9 | ||
co-expressed gene | 0.89 | ||
histone modification site profile | 0.87 | ||
kinase perturbation | 0.84 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 107.09 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 251 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 107.09 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 251 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (74)
AKR7A3
Family: Enzyme
Novelty: 0.10681298
p_int: 0.999994409
p_ni: 0.000005591
Score: 0.981
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (8)
Reactome (3)
KEGG (1)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Aflatoxin activation and detoxification | ||||
Reactome | Biological oxidations | ||||
Reactome | Metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Aflatoxin activation and detoxification | ||||
Biological oxidations | ||||
Metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (4)
Components (3)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 2 | 2 | 2 | 89.6 | |||||
urinary metabolite measurement | 1 | 1 | 1 | 77.7 | |||||
viral load | 1 | 1 | 1 | 68.6 | |||||
BMI-adjusted hip circumference | 1 | 3 | 3 | 62 | |||||
platelet count | 1 | 1 | 1 | 42.3 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
heel bone mineral density | 2 | 89.6 | |||||
urinary metabolite measurement | 1 | 77.7 | |||||
viral load | 1 | 68.6 | |||||
BMI-adjusted hip circumference | 3 | 62 | |||||
platelet count | 1 | 42.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | aldo-keto reductase family 7 member A2 | VGNC:11732 | 748767 | |||||
Macaque | aflatoxin B1 aldehyde reductase member 3 | 715623 | ||||||
Mouse | MGI:107796 | 110198 | ||||||
Rat | RGD:620311 | 171445 | ||||||
Dog | aldo-keto reductase family 7 member A2 | 478210 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | aldo-keto reductase family 7 member A2 | |||||
Macaque | aflatoxin B1 aldehyde reductase member 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | aldo-keto reductase family 7 member A2 | |||||
Publication Statistics
PubMed Score 107.09
PubMed score by year
PubTator Score 149.41
PubTator score by year
Related Publications
Text Mined References (22)
GeneRif Annotations (8)
Items per page:
0 of 0
PMID | Year | Title |
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