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Tbio
AKR7A2
Aflatoxin B1 aldehyde reductase member 2

Protein Summary
Description
Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction o ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000235835
  • ENSP00000235835
  • ENSG00000053371

Symbol
  • AFAR
  • AFAR1
  • AKR7
  • AFAR
  • AKR7
  • AFAR1
  • AFB1-AR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
virus perturbation
0.9
co-expressed gene
0.89
histone modification site profile
0.87
kinase perturbation
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.32   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 251   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.32   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 251   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary metabolite measurement
1
1
1
81.9
1
1
1
81.9
HIV-1 infection
1
1
1
61.5
viral load
1
1
1
61.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary metabolite measurement
1
81.9
1
81.9
HIV-1 infection
1
61.5
viral load
1
61.5
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aldo-keto reductase family 7 member A2
VGNC:11732
748767
Macaque
aflatoxin B1 aldehyde reductase member 3
715623
Mouse
MGI:107796
110198
Rat
RGD:620311
171445
Dog
aldo-keto reductase family 7 member A2
478210
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aldo-keto reductase family 7 member A2
Macaque
aflatoxin B1 aldehyde reductase member 3
Mouse
Rat
Dog
aldo-keto reductase family 7 member A2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O43488-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Aflatoxin activation and detoxification (R-HSA-5423646)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aflatoxin activation and detoxification
Reactome
Biological oxidations
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Aflatoxin activation and detoxification
Biological oxidations
Metabolism
Protein-Protein Interactions (74)
1 – 10 of 74
AKR7A3
Tbio
Family: Enzyme
Novelty: 0.10681298
p_int: 0.999994409
p_ni: 0.000005591
Score: 0.981
Data Source: BioPlex,STRINGDB
NFE2L2
Tchem
Family: TF
Novelty: 0.00043828
Score: 0.925
Data Source: STRINGDB
JUN
Tchem
Family: TF
Novelty: 0.00006856
Score: 0.916
Data Source: STRINGDB
CREB1
Tbio
Family: TF
Novelty: 0.00018059
Score: 0.901
Data Source: STRINGDB
FOS
Tbio
Family: TF
Novelty: 0.00006103
Score: 0.9
Data Source: STRINGDB
FXYD2
Tclin
Family: Enzyme
Novelty: 0.0196518
Score: 0.9
Data Source: STRINGDB
AKR1A1
Tchem
Family: Enzyme
Novelty: 0.0054436
Score: 0.779
Data Source: STRINGDB
AKR1B1
Tclin
Family: Enzyme
Novelty: 0.00045769
Score: 0.702
Data Source: STRINGDB
MCM6
Tbio
Novelty: 0.00675724
Score: 0.654
Data Source: STRINGDB
ZNF24
Tbio
Family: TF
Novelty: 0.02954446
Score: 0.645
Data Source: STRINGDB
Publication Statistics
PubMed Score  110.32

PubMed score by year
PubTator Score  149.41

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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