Tbio AKR7A2 Aflatoxin B1 aldehyde reductase member 2

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Reductase / Aflatoxin B1 Aldehyde Reductase Member 2

DTO Classes

Protein / Enzyme / Oxidoreductase / Reductase / Aflatoxin B1 Aldehyde Reductase Member 2

Protein Summary

Description

Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Uniprot Accession IDs

• O43488
• O75749
• Q5TG63

Gene Name

• AKR7A2

Ensembl ID

• ENST00000235835
• ENSP00000235835
• ENSG00000053371

Symbol

• AFAR
• AFAR1
• AKR7
• AFAR
• AKR7
• AFAR1
• AFB1-AR1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.93
virus perturbation	0.9
co-expressed gene	0.89
histone modification site profile	0.87
kinase perturbation	0.84

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.32   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 251   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.32   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 251   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (4)

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1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
urinary metabolite measurement	EFO_0005116	1	1	1		81.9
chronic kidney disease	EFO_0003884	1	1	1		81.9
HIV-1 infection	EFO_0000180	1	1	1		61.5
viral load	EFO_0010125	1	1	1		61.5

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
urinary metabolite measurement	EFO_0005116	1		81.9
chronic kidney disease	EFO_0003884	1		81.9
HIV-1 infection	EFO_0000180	1		61.5
viral load	EFO_0010125	1		61.5

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Orthologs (6)

1 – 5 of 6

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	aldo-keto reductase family 7 member A2	VGNC:11732	748767
Macaque	aflatoxin B1 aldehyde reductase member 3		715623
Mouse	aldo-keto reductase family 7, member A5 (aflatoxin aldehyde reductase)	MGI:107796	110198
Rat	aldo-keto reductase family 7, member A2	RGD:620311	171445
Dog	aldo-keto reductase family 7 member A2		478210

Species	Name	OMA	EggNOG	Inparanoid
Chimp	aldo-keto reductase family 7 member A2
Macaque	aflatoxin B1 aldehyde reductase member 3
Mouse	aldo-keto reductase family 7, member A5 (aflatoxin aldehyde reductase)
Rat	aldo-keto reductase family 7, member A2
Dog	aldo-keto reductase family 7 member A2

Protein Structure (1 Structure, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O43488-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (8)

Reactome (3)

KEGG (1)

WikiPathways (4)

Aflatoxin activation and detoxification (R-HSA-5423646)

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Find Similar Targets

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Aflatoxin activation and detoxification	20 targets	R-HSA-5423646
Reactome	Biological oxidations	221 targets	R-HSA-211859
Reactome	Metabolism	2112 targets	R-HSA-1430728

Name	Explore in Pharos	Explore in Source
Aflatoxin activation and detoxification	20 targets	R-HSA-5423646
Biological oxidations	221 targets	R-HSA-211859
Metabolism	2112 targets	R-HSA-1430728

Gene Ontology Terms (12)

Functions (4)

Components (3)

Processes (5)

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Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
phenanthrene-9,10-epoxide hydrolase activity	Inferred from Direct Assay (IDA)	UniProtKB
alditol:NADP+ 1-oxidoreductase activity	Traceable Author Statement (TAS)	ProtInc
aldo-keto reductase (NADP) activity	Traceable Author Statement (TAS)	Reactome
electron transfer activity	Traceable Author Statement (TAS)	UniProtKB

Protein-Protein Interactions (74)

Explore Interacting Targets

1 – 10 of 74

• See Interactions on String-DB

AKR7A3

Tbio

Family: Enzyme

Novelty: 0.10681298

p_int: 0.999994409

p_ni: 0.000005591

Score: 0.981

Data Source: BioPlex,STRINGDB

NFE2L2

Tchem

Family: TF

Novelty: 0.00043828

Score: 0.925

Data Source: STRINGDB

JUN

Tchem

Family: TF

Novelty: 0.00006856

Score: 0.916

Data Source: STRINGDB

CREB1

Tbio

Family: TF

Novelty: 0.00018059

Score: 0.901

Data Source: STRINGDB

FOS

Tbio

Family: TF

Novelty: 0.00006103

Score: 0.9

Data Source: STRINGDB

FXYD2

Tclin

Family: Enzyme

Novelty: 0.0196518

Score: 0.9

Data Source: STRINGDB

AKR1A1

Tchem

Family: Enzyme

Novelty: 0.0054436

Score: 0.779

Data Source: STRINGDB

AKR1B1

Tclin

Family: Enzyme

Novelty: 0.00045769

Score: 0.702

Data Source: STRINGDB

MCM6

Tbio

Novelty: 0.00675724

Score: 0.654

Data Source: STRINGDB

ZNF24

Tbio

Family: TF

Novelty: 0.02954446

Score: 0.645

Data Source: STRINGDB

Publication Statistics

PubMed Score  110.32

PubMed score by year

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PubTator Score  149.41

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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3D-structure
Acetylation
Complete proteome
Cytoplasm
Direct protein sequencing
Golgi apparatus
NADP
Oxidoreductase
Phosphoprotein
Polymorphism

GWAS Trait Find Similar Targets

chronic kidney disease
HIV-1 infection
urinary metabolite measurement
viral load

MGI Phenotype Find Similar Targets

behavior/neurological phenotype
mortality/aging