Tbio OIP5 Protein Mis18-beta

Protein Summary

Description

Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. The protein encoded by this gene localizes to centromeres, where it is essential for recruitment of CENP-A through the mediator Holliday junction recognition protein. Expression of this gene is upregulated in several cancers, making it a putative therapeutic target. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

Uniprot Accession IDs

• O43482
• Q96BX7

Gene Name

• OIP5

Ensembl ID

• ENST00000220514
• ENSP00000220514
• ENSG00000104147

Symbol

• MIS18B
• CT86
• MIS18B
• LINT-25
• MIS18beta
• hMIS18beta
• 5730547N13Rik

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.87
virus perturbation	0.68
transcription factor binding site profile	0.64
tissue sample	0.58
gene perturbation	0.55

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.61   (req: < 5)

Gene RIFs: 36   (req: <= 3)

Antibodies: 96   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.61   (req: >= 5)

Gene RIFs: 36   (req: > 3)

Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0