Tbio OIP5 Protein Mis18-beta

Protein Summary

Description

Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. The protein encoded by this gene localizes to centromeres, where it is essential for recruitment of CENP-A through the mediator Holliday junction recognition protein. Expression of this gene is upregulated in several cancers, making it a putative therapeutic target. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

Uniprot Accession IDs

• O43482
• Q96BX7

Gene Name

• OIP5

Ensembl ID

• ENST00000220514
• ENSP00000220514
• ENSG00000104147

Symbol

• MIS18B
• CT86
• MIS18B
• LINT-25
• MIS18beta
• hMIS18beta
• 5730547N13Rik

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.87
virus perturbation	0.68
transcription factor binding site profile	0.64
tissue sample	0.58
gene perturbation	0.55

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.83   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 96   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.83   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (4)

Reactome (4)

Cell Cycle (R-HSA-1640170)

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Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Chromosome Maintenance	88 targets	R-HSA-73886
Reactome	Deposition of new CENPA-containing nucleosomes at the centromere	52 targets	R-HSA-606279
Reactome	Nucleosome assembly	52 targets	R-HSA-774815

Name	Explore in Pharos	Explore in Source
Cell Cycle	597 targets	R-HSA-1640170
Chromosome Maintenance	88 targets	R-HSA-73886
Deposition of new CENPA-containing nucleosomes at the centromere	52 targets	R-HSA-606279
Nucleosome assembly	52 targets	R-HSA-774815

Gene Ontology Terms (15)

Functions (2)

Components (8)

Processes (5)

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (270)

Explore Interacting Targets

1 – 10 of 270

• See Interactions on String-DB

MIS18A

Tbio

Novelty: 0.00785124

p_int: 1

Score: 0.989

Data Source: BioPlex,Reactome,STRINGDB

CEP170

Tbio

Novelty: 0.00614876

p_int: 0.999999995

p_ni: 5e-9

Data Source: BioPlex

STX1A

Tbio

Novelty: 0.00128938

p_int: 0.999989679

p_ni: 0.000010291

p_wrong: 3e-8

Score: 0.193

Data Source: BioPlex,STRINGDB

TRAF7

Tbio

Family: Enzyme

Novelty: 0.05310289

p_int: 0.999979523

p_ni: 0.000019824

p_wrong: 6.54e-7

Data Source: BioPlex

GTF2E2

Tbio

Novelty: 0.16730745

p_int: 0.999975003

p_ni: 0.000024939

p_wrong: 5.8e-8

Data Source: BioPlex

MIS18BP1

Tbio

Novelty: 0.07604563

p_int: 0.999860708

p_ni: 0.000139279

p_wrong: 1.3e-8

Score: 0.995

Data Source: BioPlex,Reactome,STRINGDB

S100A4

Tbio

Novelty: 0.00156469

p_int: 0.999840441

p_ni: 0.000159337

p_wrong: 2.22e-7

Data Source: BioPlex

MED29

Tbio

Family: Enzyme

Novelty: 0.01553799

p_int: 0.999587127

p_ni: 0.000412861

p_wrong: 1.2e-8

Data Source: BioPlex

G0S2

Tbio

Novelty: 0.02314004

p_int: 0.997858902

p_ni: 0.000420439

p_wrong: 0.001720659

Data Source: BioPlex

PIP

Tbio

Novelty: 0.00268794

p_int: 0.995787728

p_ni: 0.000287674

p_wrong: 0.003924598

Data Source: BioPlex

Publication Statistics

PubMed Score  24.83

PubMed score by year

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PubTator Score  22.38

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MAAQPLRHRSRCATPPRGDFCGGTERAIDQASFTTSMEWDTQVVKGSSPLGPAGLGAEEPAAGPQLPSWL

1-70

QPERCAVFQCAQCHAVLADSVHLAWDLSRSLGAVVFSRVTNNVVLEAPFLVGIEGSLKGSTYNLLFCGSC

70-140

GIPVGFHLYSTHAALAALRGHFCLSSDKMVCYLLKTKAIVNASEMDIQNVPLSEKIAELKEKIVLTHNRL

140-210

KSLMKILSEVTPDQSKPEN

210-229

MAAQPLRHRSRCATPPRGDFCGGTERAIDQASFTTSMEWDTQVVKGSSPLGPAGLGAEEPAAGPQLPSWLQPERCAVFQCAQCHAVLADSVHLAWDLSRSLGAVVFSRVTNNVVLEAPFLVGIEGSLKGSTYNLLFCGSCGIPVGFHLYSTHAALAALRGHFCLSSDKMVCYLLKTKAIVNASEMDIQNVPLSEKIAELKEKIVLTHNRLKSLMKILSEVTPDQSKPEN

Find similar targets by:

Uniprot Keyword

Cell cycle
Cell division
Centromere
Chromosome
Complete proteome
Metal-binding
Mitosis
Nucleus
Phosphoprotein
Reference proteome