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Tbio
KLF4
Krueppel-like factor 4

Protein Summary
Description
Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription. This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is required for normal development of the barrier function of skin. The encoded protein is thought to control the G1-to-S transition of the cell cycle following DNA damage by mediating the tumor suppressor ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
gene perturbation
1
PubMedID
1
molecular function
0.99
virus perturbation
0.98


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1343.56   (req: < 5)
Gene RIFs: 335   (req: <= 3)
Antibodies: 864   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1343.56   (req: >= 5)
Gene RIFs: 335   (req: > 3)
Antibodies: 864   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 65
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Kruppel like factor 4
VGNC:13903
464640
Macaque
Kruppel like factor 4
711169
Mouse
MGI:1342287
16600
Rat
RGD:621445
114505
Dog
Kruppel like factor 4
481657
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Kruppel like factor 4
Macaque
Kruppel like factor 4
Mouse
Rat
Dog
Kruppel like factor 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O43474-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (23)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
FOXO-mediated transcription
Reactome
FOXO-mediated transcription of cell cycle genes
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Developmental Biology
FOXO-mediated transcription
FOXO-mediated transcription of cell cycle genes
Gene expression (Transcription)
Generic Transcription Pathway
Gene Ontology Terms (71)
Items per page:
10
1 – 10 of 14
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (288)
1 – 10 of 288
SOX2
Tbio
Family: TF
Novelty: 0.00037089
Score: 0.996
Data Source: STRINGDB
NANOG
Tbio
Family: TF
Novelty: 0.00054893
Score: 0.996
Data Source: STRINGDB
POU5F1
Tbio
Family: TF
Novelty: 0.00033974
Score: 0.994
Data Source: STRINGDB
LIN28A
Tbio
Family: TF
Novelty: 0.00199524
Score: 0.989
Data Source: STRINGDB
CTNNB1
Tchem
Novelty: 0.0000744
Score: 0.978
Data Source: STRINGDB
SMAD2
Tbio
Family: TF
Novelty: 0.00040166
Score: 0.972
Data Source: STRINGDB
EP300
Tchem
Family: Epigenetic
Novelty: 0.00055009
Score: 0.966
Data Source: STRINGDB
MYC
Tbio
Family: TF
Novelty: 0.00005734
Score: 0.951
Data Source: STRINGDB
CEBPB
Tbio
Family: TF
Novelty: 0.00068108
Score: 0.943
Data Source: STRINGDB
SMAD4
Tbio
Family: TF
Novelty: 0.00047069
Score: 0.938
Data Source: STRINGDB
Publication Statistics
PubMed Score  1343.56

PubMed score by year
PubTator Score  610

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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