Tbio HTRA2 Serine protease HTRA2, mitochondrial

Protein Summary

Description

Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive. This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

Uniprot Accession IDs

• O43464
• Q9HBZ4
• Q9P0Y3
• Q9P0Y4

Gene Name

• HTRA2

Ensembl ID

• ENST00000258080
• ENSP00000258080
• ENSG00000115317
• ENST00000352222
• ENSP00000312893

Symbol

• OMI
• PRSS25
• OMI
• MGCA8
• PARK13
• PRSS25

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.97
disease perturbation	0.95
kinase perturbation	0.95
cellular component	0.89
transcription factor binding site profile	0.84

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 334.84   (req: < 5)

Gene RIFs: 109   (req: <= 3)

Antibodies: 686   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 334.84   (req: >= 5)

Gene RIFs: 109   (req: > 3)

Antibodies: 686   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 37

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0