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Tbio
HTRA2
Serine protease HTRA2, mitochondrial

Protein Summary
Description
Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive. This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicin ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258080
  • ENSP00000258080
  • ENSG00000115317
  • ENST00000352222
  • ENSP00000312893

Symbol
  • OMI
  • PRSS25
  • OMI
  • MGCA8
  • PARK13
  • PRSS25
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.97
disease perturbation
0.95
kinase perturbation
0.95
cellular component
0.89
transcription factor binding site profile
0.84


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 334.84   (req: < 5)
Gene RIFs: 95   (req: <= 3)
Antibodies: 686   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 334.84   (req: >= 5)
Gene RIFs: 95   (req: > 3)
Antibodies: 686   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 37
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (137)
BIRC8
Tchem
Novelty:  0.05142518
p_int:  0.999805316
p_ni:  0.000194684
Score:  0.596
Data Source:  BioPlex,STRINGDB
RMND5A
Tbio
Novelty:  0.01820349
p_int:  0.995000125
p_ni:  0.004999875
Score:  0.543
Data Source:  BioPlex,STRINGDB
MMP13
Tchem
Family:  Enzyme
Novelty:  0.00057893
p_int:  0.991298641
p_ni:  0.008701359
Data Source:  BioPlex
WDYHV1
Tbio
Family:  Enzyme
Novelty:  0.1844203
p_int:  0.976573123
p_ni:  0.023426877
Score:  0.207
Data Source:  BioPlex,STRINGDB
BIRC7
Tchem
Novelty:  0.00420245
p_int:  0.949306096
p_ni:  0.050693904
Score:  0.866
Data Source:  BioPlex,STRINGDB
BIRC2
Tchem
Novelty:  0.00199701
p_int:  0.931009059
p_ni:  0.068990941
Score:  0.984
Data Source:  BioPlex,STRINGDB
MRPL4
Tbio
Novelty:  0.27290276
p_int:  0.906540907
p_ni:  0.093459093
Score:  0.215
Data Source:  BioPlex,STRINGDB
XIAP
Tchem
Family:  Enzyme
Novelty:  0.00062268
Score:  0.965
Data Source:  STRINGDB
PINK1
Tbio
Family:  Kinase
Novelty:  0.00100973
Score:  0.946
Data Source:  STRINGDB
DIABLO
Tbio
Novelty:  0.0007851
Score:  0.946
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Apoptosis - multiple species
KEGG
Parkinson disease
KEGG
Apoptosis
Name
Explore in Pharos
Explore in Source
Apoptosis - multiple species
Parkinson disease
Apoptosis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (50)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Mutant Phenotype (IMP)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
63.1
platelet count
2
1
2
57.9
platelet crit
1
1
1
48.8
appendicular lean mass
1
1
1
5.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
63.1
platelet count
2
57.9
platelet crit
1
48.8
appendicular lean mass
1
5.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HtrA serine peptidase 2
VGNC:273
459339
Macaque
HtrA serine peptidase 2
709938
Mouse
MGI:1928676
64704
Rat
RGD:1308906
297376
Dog
HtrA serine peptidase 2
VGNC:41836
475782
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HtrA serine peptidase 2
Macaque
HtrA serine peptidase 2
Mouse
Rat
Dog
HtrA serine peptidase 2
Publication Statistics
PubMed Score 334.84
PubMed score by year
PubTator Score 163.04
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title