You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
SUV39H1
Histone-lysine N-methyltransferase SUV39H1

Protein Summary
Description
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component o ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337852
  • ENSP00000337976
  • ENSG00000101945
  • ENST00000376687
  • ENSP00000365877

Symbol
  • KMT1A
  • SUV39H
  • MG44
  • KMT1A
  • SUV39H
  • H3-K9-HMTase 1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
molecular function
0.95
histone modification site profile
0.89
biological process
0.87
cellular component
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 208.82   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 377   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 208.82   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 377   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (14)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Reactome
Negative epigenetic regulation of rRNA expression
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Epigenetic regulation of gene expression
Gene expression (Transcription)
Negative epigenetic regulation of rRNA expression
Gene Ontology Terms (30)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (253)
1 – 10 of 253
MAGEC1
Tbio
Novelty: 0.01123023
p_int: 0.999996121
p_wrong: 0.000003879
Score: 0.416
Data Source: BioPlex,STRINGDB
USP34
Tbio
Family: Enzyme
Novelty: 0.16444192
p_int: 0.999882384
p_ni: 0.000117616
Score: 0.188
Data Source: BioPlex,STRINGDB
ATF7IP
Tbio
Novelty: 0.04269323
p_int: 0.999566597
p_ni: 0.000433402
p_wrong: 1e-9
Score: 0.752
Data Source: BioPlex,STRINGDB
MCMBP
Tbio
Novelty: 0.13330215
p_int: 0.999544235
p_ni: 0.000455765
Score: 0.16
Data Source: BioPlex,STRINGDB
ENKD1
Tdark
Novelty: 21.40077406
p_int: 0.999287533
p_ni: 0.000001292
p_wrong: 0.000711176
Score: 0.427
Data Source: BioPlex,STRINGDB
CBX5
Tbio
Family: Epigenetic
Novelty: 0.00653413
p_int: 0.998288402
p_ni: 0.001711598
Score: 0.921
Data Source: BioPlex,STRINGDB
ZNF644
Tbio
Family: TF
Novelty: 0.12816167
p_int: 0.997215112
p_ni: 0.002784888
Score: 0.234
Data Source: BioPlex,STRINGDB
USP24
Tbio
Family: Enzyme
Novelty: 0.07281326
p_int: 0.996884894
p_ni: 0.003115104
p_wrong: 2e-9
Score: 0.32
Data Source: BioPlex,STRINGDB
SETDB1
Tbio
Family: TF; Epigenetic
Novelty: 0.00609294
p_int: 0.996111025
p_ni: 0.003888964
p_wrong: 1.1e-8
Score: 0.589
Data Source: BioPlex,STRINGDB
MID1IP1
Tbio
Novelty: 0.11443752
p_int: 0.994031838
p_ni: 0.005352799
p_wrong: 0.000615362
Score: 0.187
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  208.82

PubMed score by year
PubTator Score  139.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer