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Tbio
MBTPS2
Membrane-bound transcription factor site-2 protease

Protein Summary
Description
Involved in regulated intramembrane proteolysis (RIP) that is the cleavage of membrane-spanning regulatory proteins by proteases within the plane of the membrane. It cleaves sterol-regulatory element-binding proteins (SREBPs) within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal fragments shuttle to the nucleus and activate gene transcription (PubMed:9659902, PubMed:27380894). Involved in RIP-mediated regulation of bone formation (PubMed:27380894). This gene encodes a intramembrane zinc metalloprotease, which is essential in development. This protease functions in the signal protein activation involved in sterol control of transcription and the ER stress response. Mutations in this gene have been associated with ichthyosis follicularis with atrichia and photophobia (IFAP syndrome); IFAP syndrome has been quantitatively linked to a reduction in cholesterol homeostasis and ER stress respons ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379484
  • ENSP00000368798
  • ENSG00000012174

Symbol
  • S2P
  • S2P
  • IFAP
  • KFSD
  • OI19
  • KFSDX
  • OLMSX
  • BRESEK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
transcription factor perturbation
0.84
transcription factor binding site profile
0.82
phenotype
0.76
histone modification site profile
0.74


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 160.35   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 141   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 160.35   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
membrane bound transcription factor peptidase, site 2
VGNC:1358
465532
Mouse
MGI:2444506
270669
Rat
RGD:1566171
302705
Dog
membrane bound transcription factor peptidase, site 2
VGNC:43065
491771
Horse
membrane bound transcription factor peptidase, site 2
VGNC:20019
100051796
Species
Name
OMA
EggNOG
Inparanoid
Chimp
membrane bound transcription factor peptidase, site 2
Mouse
Rat
Dog
membrane bound transcription factor peptidase, site 2
Horse
membrane bound transcription factor peptidase, site 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O43462-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (14)
ATF6 (ATF6-alpha) activates chaperones (R-HSA-381033)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ATF6 (ATF6-alpha) activates chaperones
Reactome
Assembly of active LPL and LIPC lipase complexes
Reactome
CREB3 factors activate genes
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
ATF6 (ATF6-alpha) activates chaperones
Assembly of active LPL and LIPC lipase complexes
CREB3 factors activate genes
Metabolism
Metabolism of lipids
Gene Ontology Terms (15)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (73)
1 – 10 of 73
NKAIN1
Tdark
Family:  Enzyme
Novelty:  0.52190272
p_int:  0.961984043
p_ni:  0.00516354
p_wrong:  0.032852417
Data Source:  BioPlex
SARAF
Tbio
Novelty:  0.0383833
p_int:  0.854827657
p_ni:  0.145074543
p_wrong:  0.0000978
Score:  0.332
Data Source:  BioPlex,STRINGDB
IL17RC
Tclin
Novelty:  0.01844832
p_int:  0.779248828
p_ni:  0.000095745
p_wrong:  0.220655427
Score:  0.189
Data Source:  BioPlex,STRINGDB
SREBF2
Tchem
Family:  TF
Novelty:  0.00171709
Score:  0.979
Data Source:  Reactome,STRINGDB
ATF6
Tbio
Family:  TF
Novelty:  0.00149266
Score:  0.976
Data Source:  Reactome,STRINGDB
SREBF1
Tbio
Family:  TF
Novelty:  0.00055257
Score:  0.973
Data Source:  Reactome,STRINGDB
CREB3L3
Tbio
Family:  TF
Novelty:  0.02519904
Score:  0.969
Data Source:  Reactome,STRINGDB
CREB3L1
Tbio
Family:  TF
Novelty:  0.02295608
Score:  0.958
Data Source:  Reactome,STRINGDB
CREB3L2
Tbio
Family:  TF
Novelty:  0.0284456
Score:  0.954
Data Source:  Reactome,STRINGDB
MBTPS1
Tchem
Family:  Enzyme
Novelty:  0.00845881
Score:  0.95
Data Source:  STRINGDB
Publication Statistics
PubMed Score  160.35

PubMed score by year
PubTator Score  87.86

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer