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Tclin
MGAM
Maltase-glucoamylase, intestinal

Protein Summary
Description
May serve as an alternate pathway for starch digestion when luminal alpha-amylase activity is reduced because of immaturity or malnutrition. May play a unique role in the digestion of malted dietary oligosaccharides used in food manufacturing. This gene encodes maltase-glucoamylase, which is a brush border membrane enzyme that plays a role in the final steps of digestion of starch. The protein has two catalytic sites identical to those of sucrase-isomaltase, but the proteins are only 59% homologous. Both are members of glycosyl hydrolase family 31, which has a variety of substrate specificities. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000549489
  • ENSP00000447378
  • ENSG00000257335
  • ENST00000620571
  • ENSP00000482292

Symbol
  • MGA
  • MGAML
  • MG
  • MGA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.94
protein domain
0.73
cellular component
0.67
cell type or tissue
0.6
tissue
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1884.81   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 33   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1884.81   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 33   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 55
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
acarbose
chemical structure image
miglitol
chemical structure image
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sensory perception of bitter taste
2
2
3
99
1,5 anhydroglucitol measurement
1
1
0
10
84.9
blood metabolite measurement
1
1
1
61.5
tea consumption measurement
1
1
1
25.3
bitter alcoholic beverage consumption measurement
1
1
1
24.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sensory perception of bitter taste
3
99
1,5 anhydroglucitol measurement
0
10
84.9
blood metabolite measurement
1
61.5
tea consumption measurement
1
25.3
bitter alcoholic beverage consumption measurement
1
24.4
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
maltase-glucoamylase
695030
Mouse
MGI:1203495
232714
Rat
Dog
maltase-glucoamylase
VGNC:43211
475523
Horse
maltase-glucoamylase
VGNC:20159
100064486
Species
Name
OMA
EggNOG
Inparanoid
Macaque
maltase-glucoamylase
Mouse
Rat
Dog
maltase-glucoamylase
Horse
maltase-glucoamylase
Protein Data Bank (12)
1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (11)
Digestion (R-HSA-8935690)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Digestion
Reactome
Digestion and absorption
Reactome
Digestion of dietary carbohydrate
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Digestion
Digestion and absorption
Digestion of dietary carbohydrate
Immune System
Innate Immune System
Gene Ontology Terms (15)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (367)
1 – 10 of 367
AMY2A
Tclin
Family: Enzyme
Novelty: 0.00132709
Score: 0.971
Data Source: STRINGDB
AMY1A
Tchem
Family: Enzyme
Novelty: 0.00210045
Score: 0.97
Data Source: STRINGDB
ATP11A
Tbio
Family: Transporter
Novelty: 0.05334905
Score: 0.97
Data Source: STRINGDB
AMY2B
Tbio
Family: Enzyme
Novelty: 0.01126737
Score: 0.964
Data Source: STRINGDB
AGL
Tbio
Novelty: 0.00166875
Score: 0.952
Data Source: STRINGDB
GLA
Tclin
Family: Enzyme
Novelty: 0.00075604
Score: 0.949
Data Source: STRINGDB
CLEC5A
Tbio
Novelty: 0.01710591
Score: 0.946
Data Source: STRINGDB
GBE1
Tbio
Family: Enzyme
Novelty: 0.00233237
Score: 0.946
Data Source: STRINGDB
SLC11A1
Tbio
Family: Transporter
Novelty: 0.00121416
Score: 0.934
Data Source: STRINGDB
PYGB
Tbio
Family: Enzyme
Novelty: 0.00224148
Score: 0.933
Data Source: STRINGDB
Publication Statistics
PubMed Score  1884.81

PubMed score by year
PubTator Score  64.27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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