MGAM
Maltase-glucoamylase, intestinal
Protein Summary
May serve as an alternate pathway for starch digestion when luminal alpha-amylase activity is reduced because of immaturity or malnutrition. May play a unique role in the digestion of malted dietary oligosaccharides used in food manufacturing. This gene encodes maltase-glucoamylase, which is a brush border membrane enzyme that plays a role in the final steps of digestion of starch. The protein has two catalytic sites identical to those of sucrase-isomaltase, but the proteins are only 59% homologous. Both are members of glycosyl hydrolase family 31, which has a variety of substrate specificities. [provided by RefSeq, Jul 2008]
- ENST00000549489
- ENSP00000447378
- ENSG00000257335
- ENST00000620571
- ENSP00000482292
- MGA
- MGAML
- MG
- MGA
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.94 | ||
protein domain | 0.73 | ||
cellular component | 0.67 | ||
cell type or tissue | 0.6 | ||
tissue | 0.55 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2275.7 (req: < 5)
Gene RIFs: 15 (req: <= 3)
Antibodies: 33 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2275.7 (req: >= 5)
Gene RIFs: 15 (req: > 3)
Antibodies: 33 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 56
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2