Tbio KCNAB3 Voltage-gated potassium channel subunit beta-3

Protein Summary

Description

Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv1.5. This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. The encoded protein is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. The encoded protein forms a heterodimer with the potassium voltage-gated channel, shaker-related subfamily, member 5 gene product and regulates the activity of the alpha subunit. [provided by RefSeq, May 2012]

Uniprot Accession IDs

• O43448
• Q4VAW0

Gene Name

• KCNAB3

Ensembl ID

• ENST00000303790
• ENSP00000302719
• ENSG00000170049

Symbol

• KCNA3B
• AKR6A9
• KCNA3B
• KCNA3.1B
• KV-BETA-3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.84
ligand (protein) perturbation	0.83
protein domain	0.73
tissue sample	0.68
cell type or tissue	0.58

Protein Classes

DTO Classes

Protein / Ion Channel / Voltage-gated Potassium Channel -Subunit (Kv) Family / Voltage-gated Potassium Channel Subunit Beta-3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.87   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 143   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.87   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0