You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
KCNAB3
Voltage-gated potassium channel subunit beta-3

Protein Summary
Description
Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv1.5. This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. The encoded protein is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. The encoded protein forms a heterodimer with the potassium voltage-gated channel, shaker-related subfamily, member 5 gene product and regulates the activity of the alpha subunit. [provided by RefSeq, May 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303790
  • ENSP00000302719
  • ENSG00000170049

Symbol
  • KCNA3B
  • AKR6A9
  • KCNA3B
  • KCNA3.1B
  • KV-BETA-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.84
ligand (protein) perturbation
0.83
protein domain
0.73
tissue sample
0.68
cell type or tissue
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.43   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.43   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
1
1
80.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
80.4
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily A regulatory beta subunit 3
VGNC:12331
455208
Macaque
potassium voltage-gated channel subfamily A regulatory beta subunit 3
716583
Mouse
MGI:1336208
16499
Rat
RGD:61830
58981
Dog
potassium voltage-gated channel subfamily A regulatory beta subunit 3
VGNC:53420
489483
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily A regulatory beta subunit 3
Macaque
potassium voltage-gated channel subfamily A regulatory beta subunit 3
Mouse
Rat
Dog
potassium voltage-gated channel subfamily A regulatory beta subunit 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O43448-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Potassium Channels
Reactome
Voltage gated Potassium channels
Name
Explore in Pharos
Explore in Source
Neuronal System
Potassium Channels
Voltage gated Potassium channels
Protein-Protein Interactions (79)
1 – 10 of 79
KCNAB2
Tbio
Family: IC
Novelty: 0.01752175
p_int: 0.999999708
p_ni: 2.92e-7
Score: 0.266
Data Source: BioPlex,Reactome,STRINGDB
MAPK8
Tchem
Family: Kinase
Novelty: 0.00055723
p_int: 0.99999692
p_ni: 0.000003075
p_wrong: 5e-9
Score: 0.222
Data Source: BioPlex,STRINGDB
HDAC6
Tclin
Family: Epigenetic
Novelty: 0.00122232
p_int: 0.999265822
p_ni: 0.000734176
p_wrong: 2e-9
Score: 0.267
Data Source: BioPlex,STRINGDB
MAD1L1
Tbio
Novelty: 0.03550138
p_int: 0.99351065
p_ni: 0.00648935
Score: 0.235
Data Source: BioPlex,STRINGDB
DHPS
Tbio
Family: Enzyme
Novelty: 0.00776893
p_int: 0.905143561
p_ni: 0.094856439
Score: 0.234
Data Source: BioPlex,STRINGDB
KCNA4
Tclin
Family: IC
Novelty: 0.00362065
Score: 0.987
Data Source: STRINGDB
KCNA5
Tclin
Family: IC
Novelty: 0.00182891
Score: 0.984
Data Source: STRINGDB
KCNB2
Tclin
Family: IC
Novelty: 0.02629102
Score: 0.979
Data Source: STRINGDB
KCNF1
Tclin
Family: IC
Novelty: 0.00797195
Score: 0.977
Data Source: STRINGDB
KCNH3
Tclin
Family: IC
Novelty: 0.05847445
Score: 0.975
Data Source: STRINGDB
Publication Statistics
PubMed Score  8.43

PubMed score by year
PubTator Score  4.21

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer