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Tbio
PPIH
Peptidyl-prolyl cis-trans isomerase H

Protein Summary
Description
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone. The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304979
  • ENSP00000306614
  • ENSG00000171960
  • ENST00000372550
  • ENSP00000361630

Symbol
  • CYP20
  • CYPH
  • CYPH
  • CYP-20
  • USA-CYP
  • SnuCyp-20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
interacting protein
0.9
transcription factor binding site profile
0.76
cellular component
0.71
transcription factor perturbation
0.61


Related Tools
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.27   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 158   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.27   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peptidylprolyl isomerase H
VGNC:6959
469303
Macaque
peptidylprolyl isomerase H
697669
Mouse
MGI:106499
66101
Rat
RGD:1564921
366461
Dog
peptidylprolyl isomerase H
VGNC:44854
606899
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peptidylprolyl isomerase H
Macaque
peptidylprolyl isomerase H
Mouse
Rat
Dog
peptidylprolyl isomerase H
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O43447-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Protein-Protein Interactions (224)
1 – 10 of 224
PRPF4
Tchem
Novelty: 0.08229072
p_int: 0.965311911
p_ni: 0.034688089
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
PRPF3
Tbio
Novelty: 0.01600014
Score: 0.999
Data Source: Reactome,STRINGDB
SNU13
Tbio
Novelty: 0.01613497
Score: 0.999
Data Source: STRINGDB
SNRPF
Tdark
Novelty: 0.17624854
Score: 0.999
Data Source: STRINGDB
PRPF31
Tbio
Novelty: 0.0105753
Score: 0.999
Data Source: STRINGDB
LSM2
Tbio
Novelty: 0.03339237
Score: 0.998
Data Source: STRINGDB
EFTUD2
Tbio
Novelty: 0.01805571
Score: 0.998
Data Source: STRINGDB
SNRPD1
Tbio
Novelty: 0.0136355
Score: 0.998
Data Source: STRINGDB
LSM3
Tbio
Novelty: 0.05044984
Score: 0.998
Data Source: STRINGDB
SNRPG
Tbio
Novelty: 0.1684808
Score: 0.997
Data Source: STRINGDB
Publication Statistics
PubMed Score  29.27

PubMed score by year
PubTator Score  13.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer