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Tbio
PPIH
Peptidyl-prolyl cis-trans isomerase H

Protein Summary
Description
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone. The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304979
  • ENSP00000306614
  • ENSG00000171960
  • ENST00000372550
  • ENSP00000361630

Symbol
  • CYP20
  • CYPH
  • CYPH
  • CYP-20
  • USA-CYP
  • SnuCyp-20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
interacting protein
0.9
transcription factor binding site profile
0.76
cellular component
0.71
transcription factor perturbation
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.99   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 158   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.99   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (224)
PRPF4
Tchem
Novelty:  0.08229072
p_int:  0.965311911
p_ni:  0.034688089
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
PRPF3
Tbio
Novelty:  0.01600014
Score:  0.999
Data Source:  Reactome,STRINGDB
SNU13
Tbio
Novelty:  0.01613497
Score:  0.999
Data Source:  STRINGDB
SNRPF
Tdark
Novelty:  0.17624854
Score:  0.999
Data Source:  STRINGDB
PRPF31
Tbio
Novelty:  0.0105753
Score:  0.999
Data Source:  STRINGDB
LSM2
Tbio
Novelty:  0.03339237
Score:  0.998
Data Source:  STRINGDB
EFTUD2
Tbio
Novelty:  0.01805571
Score:  0.998
Data Source:  STRINGDB
SNRPD1
Tbio
Novelty:  0.0136355
Score:  0.998
Data Source:  STRINGDB
LSM3
Tbio
Novelty:  0.05044984
Score:  0.998
Data Source:  STRINGDB
SNRPG
Tbio
Novelty:  0.1684808
Score:  0.997
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of RNA (R-HSA-8953854)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
1
1
65.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
65.3
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peptidylprolyl isomerase H
VGNC:6959
469303
Macaque
peptidylprolyl isomerase H
697669
Mouse
MGI:106499
66101
Rat
RGD:1564921
366461
Dog
peptidylprolyl isomerase H
VGNC:44854
606899
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peptidylprolyl isomerase H
Macaque
peptidylprolyl isomerase H
Mouse
Rat
Dog
peptidylprolyl isomerase H
Publication Statistics
PubMed Score 29.99
PubMed score by year
PubTator Score 13.12
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title