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Tbio
FIBP
Acidic fibroblast growth factor intracellular-binding protein

Protein Summary
Description
May be involved in mitogenic function of FGF1. May mediate with IER2 FGF-signaling in the establishment of laterality in the embryo (By similarity). Acidic fibroblast growth factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesis or inducing morphological changes and differentiation. The FIBP protein is an intracellular protein that binds selectively to acidic fibroblast growth factor (aFGF). It is postulated that FIBP may be involved in the mitogenic action of aFGF. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338369
  • ENSP00000344572
  • ENSG00000172500
  • ENST00000357519
  • ENSP00000350124

Symbol
  • FGFIBP
  • FIBP-1
  • TROFAS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
kinase perturbation
0.97
transcription factor binding site profile
0.84
virus perturbation
0.76
co-expressed gene
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.01   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.01   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (55)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
3
6
6
98.5
eosinophil count
3
2
3
93.7
glomerular filtration rate
5
3
6
93.1
eosinophil percentage of leukocytes
2
2
2
91.6
uric acid measurement
2
2
2
89.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
6
98.5
eosinophil count
3
93.7
glomerular filtration rate
6
93.1
eosinophil percentage of leukocytes
2
91.6
uric acid measurement
2
89.6
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FGF1 intracellular binding protein
VGNC:10276
745847
Macaque
FGF1 intracellular binding protein
715457
Mouse
MGI:1926233
58249
Rat
RGD:628715
282837
Dog
FGF1 intracellular binding protein
VGNC:40878
476019
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FGF1 intracellular binding protein
Macaque
FGF1 intracellular binding protein
Mouse
Rat
Dog
FGF1 intracellular binding protein
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O43427-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
MGI
Protein-Protein Interactions (24)
1 – 10 of 24
CDK5
Tchem
Family:  Kinase
Novelty:  0.00071394
p_int:  0.999999983
p_ni:  1.7e-8
Score:  0.778
Data Source:  BioPlex,STRINGDB
C2CD5
Tbio
Novelty:  0.40144687
p_int:  0.999999954
p_ni:  3.2e-8
p_wrong:  1.4e-8
Score:  0.927
Data Source:  BioPlex,STRINGDB
CABLES2
Tdark
Novelty:  0.35458236
p_int:  0.999999583
p_ni:  4.16e-7
p_wrong:  1e-9
Score:  0.869
Data Source:  BioPlex,STRINGDB
CABLES1
Tbio
Novelty:  0.04822454
p_int:  0.999999302
p_ni:  2e-8
p_wrong:  6.78e-7
Score:  0.857
Data Source:  BioPlex,STRINGDB
TMEM94
Tdark
Novelty:  0.39746809
p_int:  0.999999047
p_ni:  9.38e-7
p_wrong:  1.5e-8
Score:  0.816
Data Source:  BioPlex,STRINGDB
DLK1
Tchem
Novelty:  0.00212394
p_int:  0.996160744
p_ni:  0.003052594
p_wrong:  0.000786662
Score:  0.759
Data Source:  BioPlex,STRINGDB
WDFY2
Tbio
Novelty:  0.01835759
p_int:  0.995736259
p_ni:  0.001506968
p_wrong:  0.002756773
Score:  0.367
Data Source:  BioPlex,STRINGDB
CAPN2
Tchem
Novelty:  0.00431673
p_int:  0.917830342
p_ni:  0.007387207
p_wrong:  0.074782452
Data Source:  BioPlex
TMIE
Tbio
Novelty:  0.02939225
p_int:  0.851232921
p_ni:  0.003596147
p_wrong:  0.145170933
Data Source:  BioPlex
GRAMD1C
Tdark
Novelty:  0.46102163
p_int:  0.821583604
p_ni:  0.129112245
p_wrong:  0.049304151
Score:  0.228
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  10.01

PubMed score by year
PubTator Score  4.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer