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Tbio
GRID2
Glutamate receptor ionotropic, delta-2

Protein Summary
Description
Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the beta-NRX1-CBLN1-GRID2 triad complex (PubMed:27418511). The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells du ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282020
  • ENSP00000282020
  • ENSG00000152208
  • ENST00000510992
  • ENSP00000421257

Symbol
  • GLURD2
  • GluD2
  • SCAR18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.95
molecular function
0.9
trait
0.86
protein domain
0.73
phenotype
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 161.06   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 161.06   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
3
4
91.8
self reported educational attainment
1
2
2
90.1
intelligence
2
2
1
6
78.9
body mass index
1
1
1
76.6
cognitive function measurement
1
1
1
65.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
4
91.8
self reported educational attainment
2
90.1
intelligence
1
6
78.9
body mass index
1
76.6
cognitive function measurement
1
65.9
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutamate ionotropic receptor delta type subunit 2
VGNC:7421
743067
Macaque
glutamate receptor ionotropic, delta-2
704787
Mouse
MGI:95813
14804
Rat
RGD:68368
79220
Dog
glutamate ionotropic receptor delta type subunit 2
VGNC:41484
487863
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutamate ionotropic receptor delta type subunit 2
Macaque
glutamate receptor ionotropic, delta-2
Mouse
Rat
Dog
glutamate ionotropic receptor delta type subunit 2
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O43424-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (128)
1 – 10 of 128
GRID2IP
Tbio
Novelty: 0.12241834
Score: 0.945
Data Source: STRINGDB
GOPC
Tbio
Novelty: 0.01110168
Score: 0.856
Data Source: STRINGDB
CBLN1
Tbio
Novelty: 0.01830505
Score: 0.855
Data Source: STRINGDB
BECN1
Tbio
Novelty: 0.0003792
Score: 0.801
Data Source: STRINGDB
PTPN4
Tbio
Family: Enzyme
Novelty: 0.02977641
Score: 0.798
Data Source: STRINGDB
GRIA2
Tclin
Family: IC
Novelty: 0.00141257
Score: 0.762
Data Source: STRINGDB
CBLN3
Tdark
Novelty: 0.21939076
Score: 0.761
Data Source: STRINGDB
GRIA1
Tclin
Family: IC
Novelty: 0.0005008
Score: 0.74
Data Source: STRINGDB
CACNG7
Tdark
Family: IC
Novelty: 0.32460059
Score: 0.734
Data Source: STRINGDB
DLG4
Tchem
Novelty: 0.00057285
Score: 0.727
Data Source: STRINGDB
Publication Statistics
PubMed Score  161.06

PubMed score by year
PubTator Score  17.37

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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