Tbio TXNL1 Thioredoxin-like protein 1

Protein Summary

Description

Active thioredoxin with a redox potential of about -250 mV.

Uniprot Accession IDs

• O43396

Gene Name

• TXNL1

Ensembl ID

• ENST00000217515
• ENSP00000217515
• ENSG00000091164
• ENST00000590954
• ENSP00000464918

Symbol

• TRP32
• TXL
• TXNL
• Txl
• TXNL
• TRP32
• TXL-1
• HEL-S-114

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
virus perturbation	0.99
kinase perturbation	0.88
protein domain	0.85
transcription factor binding site profile	0.8

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.36   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 193   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.36   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 193   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	thioredoxin like 1	VGNC:5219	455433
Macaque	thioredoxin like 1		695194
Mouse	thioredoxin-like 1	MGI:1860078	53382
Rat	thioredoxin-like 1	RGD:621717	140922
Dog	thioredoxin like 1	VGNC:48018	483970

Species	Name	OMA	EggNOG	Inparanoid
Chimp	thioredoxin like 1
Macaque	thioredoxin like 1
Mouse	thioredoxin-like 1
Rat	thioredoxin-like 1
Dog	thioredoxin like 1

Protein Structure (2 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O43396-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Gene Ontology Terms (6)

Functions (1)

Components (4)

Processes (1)

Find Similar Targets

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
disulfide oxidoreductase activity	Inferred from Direct Assay (IDA)	UniProtKB

Protein-Protein Interactions (135)

Explore Interacting Targets

1 – 10 of 135

• See Interactions on String-DB

SPANXN4

Tdark

Novelty: 1.91062423

p_int: 0.983231138

p_ni: 0.016768862

Data Source: BioPlex

FAM24B

Tdark

Novelty: 1.04675689

p_int: 0.763035444

p_ni: 0.236964556

Data Source: BioPlex

PSMD14

Tbio

Family: Enzyme

Novelty: 0.01019285

Score: 0.967

Data Source: STRINGDB

TXNDC17

Tbio

Novelty: 0.0142537

Score: 0.929

Data Source: STRINGDB

PSMD4

Tbio

Family: Enzyme

Novelty: 0.00614538

Score: 0.898

Data Source: STRINGDB

USP14

Tchem

Family: Enzyme

Novelty: 0.00947074

Score: 0.891

Data Source: STRINGDB

PSMD13

Tbio

Family: Enzyme

Novelty: 0.04204417

Score: 0.884

Data Source: STRINGDB

PSMD6

Tbio

Family: Enzyme

Novelty: 0.04419339

Score: 0.883

Data Source: STRINGDB

PSMC1

Tbio

Family: Enzyme

Novelty: 0.04631888

Score: 0.86

Data Source: STRINGDB

PSMD3

Tbio

Family: Enzyme

Novelty: 0.03106272

Score: 0.829

Data Source: STRINGDB

Publication Statistics

PubMed Score  80.36

PubMed score by year

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PubTator Score  51.93

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Complete proteome
Cytoplasm
Direct protein sequencing
Disulfide bond
Electron transport
Nucleus
Phosphoprotein
Proteasome
Redox-active center