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Tbio
TXNL1
Thioredoxin-like protein 1

Protein Summary
Description
Active thioredoxin with a redox potential of about -250 mV.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217515
  • ENSP00000217515
  • ENSG00000091164
  • ENST00000590954
  • ENSP00000464918

Symbol
  • TRP32
  • TXL
  • TXNL
  • Txl
  • TXNL
  • TRP32
  • TXL-1
  • HEL-S-114
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
virus perturbation
0.99
kinase perturbation
0.88
protein domain
0.85
transcription factor binding site profile
0.8


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.36   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 193   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.36   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 193   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
thioredoxin like 1
VGNC:5219
455433
Macaque
thioredoxin like 1
695194
Mouse
MGI:1860078
53382
Rat
RGD:621717
140922
Dog
thioredoxin like 1
VGNC:48018
483970
Species
Name
OMA
EggNOG
Inparanoid
Chimp
thioredoxin like 1
Macaque
thioredoxin like 1
Mouse
Rat
Dog
thioredoxin like 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O43396-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (135)
1 – 10 of 135
SPANXN4
Tdark
Novelty: 1.91062423
p_int: 0.983231138
p_ni: 0.016768862
Data Source: BioPlex
FAM24B
Tdark
Novelty: 1.04675689
p_int: 0.763035444
p_ni: 0.236964556
Data Source: BioPlex
PSMD14
Tbio
Family: Enzyme
Novelty: 0.01019285
Score: 0.967
Data Source: STRINGDB
TXNDC17
Tbio
Novelty: 0.0142537
Score: 0.929
Data Source: STRINGDB
PSMD4
Tbio
Family: Enzyme
Novelty: 0.00614538
Score: 0.898
Data Source: STRINGDB
USP14
Tchem
Family: Enzyme
Novelty: 0.00947074
Score: 0.891
Data Source: STRINGDB
PSMD13
Tbio
Family: Enzyme
Novelty: 0.04204417
Score: 0.884
Data Source: STRINGDB
PSMD6
Tbio
Family: Enzyme
Novelty: 0.04419339
Score: 0.883
Data Source: STRINGDB
PSMC1
Tbio
Family: Enzyme
Novelty: 0.04631888
Score: 0.86
Data Source: STRINGDB
PSMD3
Tbio
Family: Enzyme
Novelty: 0.03106272
Score: 0.829
Data Source: STRINGDB
Publication Statistics
PubMed Score  80.36

PubMed score by year
PubTator Score  51.93

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer