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Tbio
HNRNPR
Heterogeneous nuclear ribonucleoprotein R

Protein Summary
Description
Component of ribonucleosomes, which are complexes of at least 20 other different heterogenious nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus. This gene encodes an RNA-binding protein that is a member of the spliceosome C complex, which functions in pre-mRNA processing and transport. The encoded protein also promotes transcription at the c-fos gene. Alternative splicing results in multiple transcript variants. There are pseudogenes for this gene on chromosomes 4, 11, and 10. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302271
  • ENSP00000304405
  • ENSG00000125944
  • ENST00000374612
  • ENSP00000363741
  • ENST00000374616
  • ENSP00000363745
  • ENST00000427764
  • ENSP00000392799
  • ENST00000478691
  • ENSP00000474437
  • ENST00000634263
  • ENSP00000489371
  • ENSG00000282958
  • ENST00000634634
  • ENSP00000488941
  • ENST00000634713
  • ENSP00000488945
  • ENST00000634766
  • ENSP00000489252
  • ENST00000635150
  • ENSP00000489275

Symbol
  • HNRPR
  • HNRPR
  • hnRNP-R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
interacting protein
1
kinase perturbation
0.96
hub protein
0.88
transcription factor binding site profile
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.81   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 168   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.81   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
1
1
1
47.4
waist-hip ratio
1
1
1
47.4
monocyte percentage of leukocytes
1
1
1
28.7
monocyte percentage of leukocytes
1
1
1
28.7
glomerular filtration rate
1
1
0
7.8
4.7
Items per page:
1 – 5 of 5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
1
47.4
waist-hip ratio
1
47.4
monocyte percentage of leukocytes
1
28.7
monocyte percentage of leukocytes
1
28.7
glomerular filtration rate
0
7.8
4.7
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
heterogeneous nuclear ribonucleoprotein R
VGNC:1263
456615
Macaque
heterogeneous nuclear ribonucleoprotein R
718721
Mouse
MGI:1891692
74326
Rat
RGD:631348
319110
Dog
heterogeneous nuclear ribonucleoprotein R
VGNC:41735
478192
Species
Name
OMA
EggNOG
Inparanoid
Chimp
heterogeneous nuclear ribonucleoprotein R
Macaque
heterogeneous nuclear ribonucleoprotein R
Mouse
Rat
Dog
heterogeneous nuclear ribonucleoprotein R
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O43390-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Gene Ontology Terms (16)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (390)
1 – 10 of 390
STRBP
Tbio
Novelty: 0.00919158
p_int: 0.999999928
p_ni: 7.2e-8
Score: 0.853
Data Source: BioPlex,STRINGDB
ZFR
Tbio
Novelty: 0.01859772
p_int: 0.999605908
p_ni: 0.000394092
Score: 0.855
Data Source: BioPlex,STRINGDB
PRMT8
Tchem
Family: Epigenetic
Novelty: 0.04213384
p_int: 0.999453057
p_ni: 0.000546943
Score: 0.634
Data Source: BioPlex,STRINGDB
ILF2
Tbio
Novelty: 0.01598188
p_int: 0.998886118
p_ni: 0.001113882
Score: 0.98
Data Source: BioPlex,STRINGDB
APOBEC3D
Tbio
Novelty: 0.01102619
p_int: 0.983906223
p_ni: 0.016093777
Score: 0.481
Data Source: BioPlex,STRINGDB
ELAVL2
Tbio
Novelty: 0.00370708
p_int: 0.942197238
p_ni: 0.057802759
p_wrong: 4e-9
Score: 0.923
Data Source: BioPlex,STRINGDB
HNRNPA1
Tchem
Novelty: 0.0020871
p_int: 0.937862233
p_ni: 0.062137767
Score: 0.998
Data Source: BioPlex,STRINGDB
SNRNP70
Tbio
Novelty: 0.00116631
p_int: 0.907644782
p_ni: 0.092355218
Score: 0.992
Data Source: BioPlex,STRINGDB
MRPS5
Tbio
Novelty: 0.11423336
p_int: 0.902959584
p_ni: 0.097040416
Score: 0.535
Data Source: BioPlex,STRINGDB
ZNF169
Tdark
Family: TF
Novelty: 1.09432767
p_int: 0.892396142
p_ni: 0.107603843
p_wrong: 1.5e-8
Score: 0.532
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  14.81

PubMed score by year
PubTator Score  10.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer