You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
HOXA3
Homeobox protein Hox-A3

Protein Summary
Description
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317201
  • ENSP00000324884
  • ENSG00000105997
  • ENST00000396352
  • ENSP00000379640
  • ENST00000612286
  • ENSP00000484411

Symbol
  • HOX1E
  • HOX1
  • HOX1E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
PubMedID
0.83
microRNA
0.76
virus perturbation
0.64
tissue sample
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.81   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 173   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.81   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (39)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
7
12
96.2
BMI-adjusted waist-hip ratio
9
13
20
96
waist-hip ratio
5
15
16
91.3
diastolic blood pressure
5
7
10
91.1
waist circumference
1
7
7
86.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
12
96.2
BMI-adjusted waist-hip ratio
20
96
waist-hip ratio
16
91.3
diastolic blood pressure
10
91.1
waist circumference
7
86.4
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
homeobox A3
VGNC:14024
472323
Mouse
MGI:96175
15400
Dog
homeobox A3
VGNC:41747
482368
Horse
homeobox A3 [Source:HGNC Symbol;Acc:HGNC:5104]
Cow
homeobox A3
VGNC:29911
509991
Species
Name
OMA
EggNOG
Inparanoid
Chimp
homeobox A3
Mouse
Dog
homeobox A3
Horse
homeobox A3 [Source:HGNC Symbol;Acc:HGNC:5104]
Cow
homeobox A3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O43365-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Activation of HOX genes during differentiation (R-HSA-5619507)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Developmental Biology
Gene Ontology Terms (27)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (97)
1 – 10 of 97
GUSB
Tchem
Family:  Enzyme
Novelty:  0.00053974
p_int:  0.999930799
p_wrong:  0.000069201
Score:  0.688
Data Source:  BioPlex,STRINGDB
PBX1
Tbio
Family:  TF
Novelty:  0.00329442
Score:  0.961
Data Source:  STRINGDB
PKNOX1
Tbio
Family:  TF
Novelty:  0.01063674
Score:  0.96
Data Source:  STRINGDB
HOXB1
Tbio
Family:  TF
Novelty:  0.00731831
Score:  0.927
Data Source:  STRINGDB
MAFB
Tbio
Family:  TF
Novelty:  0.00646074
Score:  0.926
Data Source:  STRINGDB
ASH2L
Tbio
Family:  Enzyme
Novelty:  0.01586766
Score:  0.922
Data Source:  STRINGDB
KDM6A
Tchem
Family:  Epigenetic
Novelty:  0.00267001
Score:  0.915
Data Source:  STRINGDB
CTCF
Tbio
Family:  TF
Novelty:  0.00085923
Score:  0.914
Data Source:  STRINGDB
WDR5
Tchem
Novelty:  0.0059945
Score:  0.912
Data Source:  STRINGDB
KMT2C
Tbio
Family:  Epigenetic
Novelty:  0.00689437
Score:  0.911
Data Source:  STRINGDB
Publication Statistics
PubMed Score  69.81

PubMed score by year
PubTator Score  23.11

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: