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Tbio
HOXA2
Homeobox protein Hox-A2

Protein Summary
Description
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. The encoded protein may be involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222718
  • ENSP00000222718
  • ENSG00000105996

Symbol
  • HOX1K
  • HOX1K
  • MCOHI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.9
gene perturbation
0.76
PubMedID
0.76
protein domain
0.73
cell type or tissue
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122.84   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122.84   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (90)
PBX1
Tbio
Family:  TF
Novelty:  0.00329442
Score:  0.953
Data Source:  STRINGDB
EGR2
Tbio
Family:  TF
Novelty:  0.00215433
Score:  0.952
Data Source:  STRINGDB
PKNOX1
Tbio
Family:  TF
Novelty:  0.01063674
Score:  0.95
Data Source:  STRINGDB
ROBO1
Tbio
Novelty:  0.00494884
Score:  0.939
Data Source:  STRINGDB
ROBO2
Tbio
Novelty:  0.00757203
Score:  0.933
Data Source:  STRINGDB
LHX2
Tbio
Family:  TF
Novelty:  0.00915095
Score:  0.928
Data Source:  STRINGDB
HOXB1
Tbio
Family:  TF
Novelty:  0.00731831
Score:  0.926
Data Source:  STRINGDB
RCHY1
Tbio
Novelty:  0.01853663
Score:  0.924
Data Source:  STRINGDB
WDR5
Tchem
Novelty:  0.0059945
Score:  0.921
Data Source:  STRINGDB
ASH2L
Tbio
Family:  Enzyme
Novelty:  0.01586766
Score:  0.92
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Activation of HOX genes during differentiation (R-HSA-5619507)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Regulation of expression of SLITs and ROBOs
Name
Explore in Pharos
Explore in Source
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Axon guidance
Developmental Biology
Regulation of expression of SLITs and ROBOs
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (23)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (32)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
6
10
95.9
BMI-adjusted waist-hip ratio
8
11
18
95.6
waist-hip ratio
4
13
14
91.1
waist circumference
1
7
7
86.4
BMI-adjusted waist circumference
3
8
9
79.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
10
95.9
BMI-adjusted waist-hip ratio
18
95.6
waist-hip ratio
14
91.1
waist circumference
7
86.4
BMI-adjusted waist circumference
9
79.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
homeobox A2
VGNC:14023
472322
Mouse
MGI:96174
15399
Rat
RGD:2813
103690123
Dog
homeobox A2
VGNC:54768
609592
Horse
homeobox A2
VGNC:49464
100054296
Species
Name
OMA
EggNOG
Inparanoid
Chimp
homeobox A2
Mouse
Rat
Dog
homeobox A2
Horse
homeobox A2
Publication Statistics
PubMed Score 122.84
PubMed score by year
PubTator Score 40.69
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title