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Tbio
MSI1
RNA-binding protein Musashi homolog 1

Protein Summary
Description
RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity). This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257552
  • ENSP00000257552
  • ENSG00000135097
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.58
biological term
0.57
hub protein
0.53
cell type or tissue
0.5
small molecule perturbation
0.49


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 175.89   (req: < 5)
Gene RIFs: 67   (req: <= 3)
Antibodies: 530   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 175.89   (req: >= 5)
Gene RIFs: 67   (req: > 3)
Antibodies: 530   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
musashi RNA binding protein 1
VGNC:13253
452305
Macaque
musashi RNA binding protein 1
699286
Mouse
MGI:107376
17690
Rat
RGD:628778
259272
Dog
musashi RNA binding protein 1
VGNC:43442
611488
Species
Name
OMA
EggNOG
Inparanoid
Chimp
musashi RNA binding protein 1
Macaque
musashi RNA binding protein 1
Mouse
Rat
Dog
musashi RNA binding protein 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O43347-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Regulation of expression of SLITs and ROBOs
Reactome
Signaling by ROBO receptors
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Regulation of expression of SLITs and ROBOs
Signaling by ROBO receptors
Gene Ontology Terms (8)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (73)
1 – 10 of 73
LOXL3
Tbio
Family: Enzyme
Novelty: 0.03895154
p_int: 0.987470628
p_ni: 0.012529372
Score: 0.369
Data Source: BioPlex,STRINGDB
ROBO2
Tbio
Novelty: 0.00757203
Score: 0.914
Data Source: STRINGDB
LHX2
Tbio
Family: TF
Novelty: 0.00915095
Score: 0.906
Data Source: STRINGDB
RBX1
Tbio
Family: Enzyme
Novelty: 0.00596986
Score: 0.904
Data Source: STRINGDB
CUL2
Tbio
Novelty: 0.00512916
Score: 0.903
Data Source: STRINGDB
ROBO1
Tbio
Novelty: 0.00494884
Score: 0.903
Data Source: STRINGDB
ZSWIM8
Tdark
Novelty: 0.26740136
Score: 0.902
Data Source: STRINGDB
ELOB
Tbio
Novelty: 0.01315739
Score: 0.9
Data Source: STRINGDB
ELOC
Tbio
Novelty: 0.00964847
Score: 0.9
Data Source: STRINGDB
LHX9
Tbio
Family: TF
Novelty: 0.02952374
Score: 0.9
Data Source: STRINGDB
Publication Statistics
PubMed Score  175.89

PubMed score by year
PubTator Score  161.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer