Tbio EEF1E1 Eukaryotic translation elongation factor 1 epsilon-1

Protein Summary

Description

Positive modulator of ATM response to DNA damage. This gene encodes a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog) gene. An EEF1E1-related pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2010]

Uniprot Accession IDs

• O43324
• C9JLK5
• Q5THS2

Gene Name

• EEF1E1

Ensembl ID

• ENST00000379715
• ENSP00000369038
• ENSG00000124802
• ENST00000429723
• ENSP00000414363

Symbol

• AIMP3
• P18
• P18
• AIMP3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.99
interacting protein	0.91
histone modification site profile	0.72
transcription factor binding site profile	0.72
disease perturbation	0.68

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.95   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 189   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.95   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 189   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Protein-Protein Interactions (113)

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1 – 10 of 113

• See Interactions on String-DB

KARS

Tchem

Family:  Enzyme

Novelty:  0.00386511

p_int:  0.998835167

p_ni:  0.001164833

Score:  0.994

Data Source:  BioPlex,STRINGDB

RARS

Tchem

Family:  Enzyme

Novelty:  0.00099479

p_int:  0.998485918

p_ni:  0.001514082

Score:  0.997

Data Source:  BioPlex,STRINGDB

AIMP1

Tbio

Family:  Enzyme

Novelty:  0.00743447

p_int:  0.998215101

p_ni:  0.001784899

Score:  0.999

Data Source:  BioPlex,STRINGDB

QARS

Tchem

Family:  Enzyme

Novelty:  0.01684657

p_int:  0.995857055

p_ni:  0.004142945

Score:  0.993

Data Source:  BioPlex,STRINGDB

LARS

Tchem

Family:  Enzyme

Novelty:  0.00361711

p_int:  0.992659961

p_ni:  0.007340039

Score:  0.993

Data Source:  BioPlex,STRINGDB

SDCBP

Tbio

Novelty:  0.00242211

p_int:  0.95271146

p_ni:  0.04728854

Score:  0.809

Data Source:  BioPlex,STRINGDB

MARS

Tchem

Family:  Enzyme

Novelty:  0.01318702

Score:  0.999

Data Source:  STRINGDB

AIMP2

Tchem

Family:  Enzyme

Novelty:  0.03283387

Score:  0.999

Data Source:  STRINGDB

EPRS

Tchem

Family:  Enzyme

Novelty:  0.00084896

Score:  0.999

Data Source:  STRINGDB

IARS

Tchem

Family:  Enzyme

Novelty:  0.00539046

Score:  0.993

Data Source:  STRINGDB

Pathways (8)

Reactome (7)

WikiPathways (1)

Cytosolic tRNA aminoacylation (R-HSA-379716)

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5

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytosolic tRNA aminoacylation	24 targets	R-HSA-379716
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of amino acids and derivatives	373 targets	R-HSA-71291
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Selenoamino acid metabolism	119 targets	R-HSA-2408522

Name	Explore in Pharos	Explore in Source
Cytosolic tRNA aminoacylation	24 targets	R-HSA-379716
Metabolism	2112 targets	R-HSA-1430728
Metabolism of amino acids and derivatives	373 targets	R-HSA-71291
Metabolism of proteins	2050 targets	R-HSA-392499
Selenoamino acid metabolism	119 targets	R-HSA-2408522

Gene Ontology Terms (11)

Components (6)

Processes (5)

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Items per page:

10

1 – 6 of 6

GO Term	Evidence	Assigned by
aminoacyl-tRNA synthetase multienzyme complex	Inferred from Direct Assay (IDA)	UniProtKB
cytosol	Inferred from Direct Assay (IDA)	UniProtKB
nucleolus	Inferred from Direct Assay (IDA)	HPA
nucleoplasm	Inferred from Direct Assay (IDA)	HPA
nucleus	Inferred from Direct Assay (IDA)	HPA
cytoplasm	Inferred from Sequence or structural Similarity (ISS)	UniProtKB

GWAS Traits (1)

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5

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular hemoglobin concentration	EFO_0004528	1	1	1		63.1

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5

1 – 1 of 1

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular hemoglobin concentration	EFO_0004528	1		63.1

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Coiled coil
Complete proteome
Cytoplasm
Direct protein sequencing
Nucleus
Protein biosynthesis
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
mean corpuscular hemoglobin concentration

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
hematopoietic system phenotype
immune system phenotype
mortality/aging
neoplasm

Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	eukaryotic translation elongation factor 1 epsilon 1		462423
Macaque	eukaryotic translation elongation factor 1 epsilon 1		695426
Mouse	eukaryotic translation elongation factor 1 epsilon 1	MGI:1913393	66143
Rat	eukaryotic translation elongation factor 1 epsilon 1	RGD:1311056	291057
Dog	eukaryotic translation elongation factor 1 epsilon 1		478717

Species	Name	OMA	EggNOG	Inparanoid
Chimp	eukaryotic translation elongation factor 1 epsilon 1
Macaque	eukaryotic translation elongation factor 1 epsilon 1
Mouse	eukaryotic translation elongation factor 1 epsilon 1
Rat	eukaryotic translation elongation factor 1 epsilon 1
Dog	eukaryotic translation elongation factor 1 epsilon 1

Publication Statistics

PubMed Score 20.95

PubMed score by year

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PubTator Score 12.12

PubTator score by year

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