EEF1E1
Eukaryotic translation elongation factor 1 epsilon-1
Protein Summary
Positive modulator of ATM response to DNA damage. This gene encodes a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog) gene. An EEF1E1-related pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2010]
- ENST00000379715
- ENSP00000369038
- ENSG00000124802
- ENST00000429723
- ENSP00000414363
- AIMP3
- P18
- P18
- AIMP3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.99 | ||
interacting protein | 0.91 | ||
histone modification site profile | 0.72 | ||
transcription factor binding site profile | 0.72 | ||
disease perturbation | 0.68 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 18.96 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 189 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 18.96 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 189 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | eukaryotic translation elongation factor 1 epsilon 1 | 462423 | ||||||
Macaque | eukaryotic translation elongation factor 1 epsilon 1 | 695426 | ||||||
Mouse | MGI:1913393 | 66143 | ||||||
Rat | RGD:1311056 | 291057 | ||||||
Dog | eukaryotic translation elongation factor 1 epsilon 1 | 478717 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | eukaryotic translation elongation factor 1 epsilon 1 | |||||
Macaque | eukaryotic translation elongation factor 1 epsilon 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | eukaryotic translation elongation factor 1 epsilon 1 | |||||
Protein Structure (6 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 6
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (8)
Reactome (7)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 7
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytosolic tRNA aminoacylation | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of amino acids and derivatives | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Selenoamino acid metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytosolic tRNA aminoacylation | ||||
Metabolism | ||||
Metabolism of amino acids and derivatives | ||||
Metabolism of proteins | ||||
Selenoamino acid metabolism | ||||
Gene Ontology Terms (11)
Components (6)
Processes (5)
Items per page:
10
1 – 6 of 6
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | HPA | |||
Inferred from Direct Assay (IDA) | HPA | |||
Inferred from Direct Assay (IDA) | HPA | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Protein-Protein Interactions (113)
1 – 10 of 113
KARS
Family: Enzyme
Novelty: 0.00386511
p_int: 0.998835167
p_ni: 0.001164833
Score: 0.994
Data Source: BioPlex,STRINGDB
RARS
Family: Enzyme
Novelty: 0.00099479
p_int: 0.998485918
p_ni: 0.001514082
Score: 0.997
Data Source: BioPlex,STRINGDB
AIMP1
Family: Enzyme
Novelty: 0.00743447
p_int: 0.998215101
p_ni: 0.001784899
Score: 0.999
Data Source: BioPlex,STRINGDB
QARS
Family: Enzyme
Novelty: 0.01684657
p_int: 0.995857055
p_ni: 0.004142945
Score: 0.993
Data Source: BioPlex,STRINGDB
LARS
Family: Enzyme
Novelty: 0.00361711
p_int: 0.992659961
p_ni: 0.007340039
Score: 0.993
Data Source: BioPlex,STRINGDB
SDCBP
Novelty: 0.00242211
p_int: 0.95271146
p_ni: 0.04728854
Score: 0.809
Data Source: BioPlex,STRINGDB
MARS
Family: Enzyme
Novelty: 0.01318702
Score: 0.999
Data Source: STRINGDB
AIMP2
Family: Enzyme
Novelty: 0.03283387
Score: 0.999
Data Source: STRINGDB
EPRS
Family: Enzyme
Novelty: 0.00084896
Score: 0.999
Data Source: STRINGDB
IARS
Family: Enzyme
Novelty: 0.00539046
Score: 0.993
Data Source: STRINGDB
Publication Statistics
PubMed Score 18.96
PubMed score by year
PubTator Score 12.12
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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