EEF1E1
Eukaryotic translation elongation factor 1 epsilon-1
Protein Summary
Positive modulator of ATM response to DNA damage. This gene encodes a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog) gene. An EEF1E1-related pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2010]
- ENST00000379715
- ENSP00000369038
- ENSG00000124802
- ENST00000429723
- ENSP00000414363
- AIMP3
- P18
- P18
- AIMP3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.99 | ||
interacting protein | 0.91 | ||
histone modification site profile | 0.72 | ||
transcription factor binding site profile | 0.72 | ||
disease perturbation | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22.66 (req: < 5)
Gene RIFs: 15 (req: <= 3)
Antibodies: 189 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22.66 (req: >= 5)
Gene RIFs: 15 (req: > 3)
Antibodies: 189 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0