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Tbio
EEF1E1
Eukaryotic translation elongation factor 1 epsilon-1

Protein Summary
Description
Positive modulator of ATM response to DNA damage. This gene encodes a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog) gene. An EEF1E1-related pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379715
  • ENSP00000369038
  • ENSG00000124802
  • ENST00000429723
  • ENSP00000414363

Symbol
  • AIMP3
  • P18
  • P18
  • AIMP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
interacting protein
0.91
histone modification site profile
0.72
transcription factor binding site profile
0.72
disease perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.95   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 189   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.95   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 189   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (113)
KARS
Tchem
Family:  Enzyme
Novelty:  0.00386511
p_int:  0.998835167
p_ni:  0.001164833
Score:  0.994
Data Source:  BioPlex,STRINGDB
RARS
Tchem
Family:  Enzyme
Novelty:  0.00099479
p_int:  0.998485918
p_ni:  0.001514082
Score:  0.997
Data Source:  BioPlex,STRINGDB
AIMP1
Tbio
Family:  Enzyme
Novelty:  0.00743447
p_int:  0.998215101
p_ni:  0.001784899
Score:  0.999
Data Source:  BioPlex,STRINGDB
QARS
Tchem
Family:  Enzyme
Novelty:  0.01684657
p_int:  0.995857055
p_ni:  0.004142945
Score:  0.993
Data Source:  BioPlex,STRINGDB
LARS
Tchem
Family:  Enzyme
Novelty:  0.00361711
p_int:  0.992659961
p_ni:  0.007340039
Score:  0.993
Data Source:  BioPlex,STRINGDB
SDCBP
Tbio
Novelty:  0.00242211
p_int:  0.95271146
p_ni:  0.04728854
Score:  0.809
Data Source:  BioPlex,STRINGDB
MARS
Tchem
Family:  Enzyme
Novelty:  0.01318702
Score:  0.999
Data Source:  STRINGDB
AIMP2
Tchem
Family:  Enzyme
Novelty:  0.03283387
Score:  0.999
Data Source:  STRINGDB
EPRS
Tchem
Family:  Enzyme
Novelty:  0.00084896
Score:  0.999
Data Source:  STRINGDB
IARS
Tchem
Family:  Enzyme
Novelty:  0.00539046
Score:  0.993
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Cytosolic tRNA aminoacylation (R-HSA-379716)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic tRNA aminoacylation
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Metabolism of proteins
Reactome
Selenoamino acid metabolism
Name
Explore in Pharos
Explore in Source
Cytosolic tRNA aminoacylation
Metabolism
Metabolism of amino acids and derivatives
Metabolism of proteins
Selenoamino acid metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
63.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
63.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation elongation factor 1 epsilon 1
462423
Macaque
eukaryotic translation elongation factor 1 epsilon 1
695426
Mouse
MGI:1913393
66143
Rat
RGD:1311056
291057
Dog
eukaryotic translation elongation factor 1 epsilon 1
478717
Species
Name
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation elongation factor 1 epsilon 1
Macaque
eukaryotic translation elongation factor 1 epsilon 1
Mouse
Rat
Dog
eukaryotic translation elongation factor 1 epsilon 1
Publication Statistics
PubMed Score 20.95
PubMed score by year
PubTator Score 12.12
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title