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Tbio
DHH
Desert hedgehog protein

Protein Summary
Description
Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development. This gene encodes a member of the hedgehog family. The hedgehog gene family encodes signaling molecules that play an important role in regulating morphogenesis. This protein is predicted to be made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. Defects in this protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. This protein may be involved in both male gonadal differentiation and perin ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266991
  • ENSP00000266991
  • ENSG00000139549
  • ENST00000649637
  • ENSP00000497483

Symbol
  • GDXYM
  • HHG-3
  • SRXY7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
tissue sample
0.71
PubMedID
0.69
phenotype
0.56
transcription factor
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 245.8   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 366   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 245.8   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 366   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (144)
RPIA
Tbio
Family:  Enzyme
Novelty:  0.00968705
p_int:  0.999998815
p_ni:  0.000001185
Score:  0.228
Data Source:  BioPlex,STRINGDB
EIPR1
Tbio
Novelty:  0.08803081
p_int:  0.999998646
p_ni:  0.000001354
Score:  0.171
Data Source:  BioPlex,STRINGDB
HSPA5
Tchem
Novelty:  0.00043424
p_int:  0.914240825
p_ni:  0.085759175
Data Source:  BioPlex
RCC1L
Tbio
Novelty:  0.03545003
p_int:  0.887987485
p_ni:  0.112012515
Score:  0.269
Data Source:  BioPlex,STRINGDB
FKBP14
Tbio
Family:  Enzyme
Novelty:  0.02742616
p_int:  0.837681697
p_ni:  0.13633547
p_wrong:  0.025982834
Score:  0.165
Data Source:  BioPlex,STRINGDB
NME6
Tbio
Family:  Kinase
Novelty:  0.12087274
p_int:  0.758025154
p_ni:  0.228127375
p_wrong:  0.013847471
Score:  0.315
Data Source:  BioPlex,STRINGDB
HHIP
Tbio
Novelty:  0.00982404
Score:  0.995
Data Source:  STRINGDB
PTCH1
Tbio
Novelty:  0.00077635
Score:  0.994
Data Source:  STRINGDB
BOC
Tbio
Novelty:  0.10938194
Score:  0.992
Data Source:  STRINGDB
CDON
Tbio
Novelty:  0.00447262
Score:  0.991
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (36)
Activation of SMO (R-HSA-5635838)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of SMO
Reactome
Class B/2 (Secretin family receptors)
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Activation of SMO
Class B/2 (Secretin family receptors)
Disease
Diseases of signal transduction
GPCR ligand binding
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
2
5
89
cognitive function measurement
3
2
3
86.2
intelligence
6
6
4
6.1
83.3
HbA1c measurement
1
2
2
76.2
self reported educational attainment
4
1
3
6.1
74.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
5
89
cognitive function measurement
3
86.2
intelligence
4
6.1
83.3
HbA1c measurement
2
76.2
self reported educational attainment
3
6.1
74.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
desert hedgehog
711048
Mouse
MGI:94891
13363
Rat
RGD:620711
84380
Dog
desert hedgehog
VGNC:39930
100685337
Horse
desert hedgehog
VGNC:17161
100059016
Species
Name
OMA
EggNOG
Inparanoid
Macaque
desert hedgehog
Mouse
Rat
Dog
desert hedgehog
Horse
desert hedgehog
Publication Statistics
PubMed Score 245.80
PubMed score by year
PubTator Score 61.61
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title