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Tchem
MAP3K7
Mitogen-activated protein kinase kinase kinase 7

Protein Summary
Description
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369325
  • ENSP00000358331
  • ENSG00000135341
  • ENST00000369327
  • ENSP00000358333
  • ENST00000369329
  • ENSP00000358335
  • ENST00000369332
  • ENSP00000358338

Symbol
  • TAK1
  • CSCF
  • FMD2
  • TAK1
  • MEKK7
  • TGF1a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
kinase perturbation
0.99
molecular function
0.99
transcription factor perturbation
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 244.18   (req: < 5)
Gene RIFs: 179   (req: <= 3)
Antibodies: 1045   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 244.18   (req: >= 5)
Gene RIFs: 179   (req: > 3)
Antibodies: 1045   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 42
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1