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Tchem
MAP3K7
Mitogen-activated protein kinase kinase kinase 7

Protein Summary
Description
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369325
  • ENSP00000358331
  • ENSG00000135341
  • ENST00000369327
  • ENSP00000358333
  • ENST00000369329
  • ENSP00000358335
  • ENST00000369332
  • ENSP00000358338

Symbol
  • TAK1
  • CSCF
  • FMD2
  • TAK1
  • MEKK7
  • TGF1a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
kinase perturbation
0.99
molecular function
0.99
transcription factor perturbation
0.94


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 200.75   (req: < 5)
Gene RIFs: 144   (req: <= 3)
Antibodies: 1045   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 200.75   (req: >= 5)
Gene RIFs: 144   (req: > 3)
Antibodies: 1045   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 39
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
nintedanib
chemical structure image
Active Ligands (39)
1 – 10 of 39
CHEMBL603469
chemical structure image
CHEMBL574738
chemical structure image
CHEMBL1908395,CHEMBL1908842
chemical structure image
RGB-286638
chemical structure image
CHEMBL2010872
chemical structure image
NG-25
chemical structure image
CHEMBL2207198
chemical structure image
Takinib
chemical structure image
CHEMBL3735673
chemical structure image
CHEMBL1077979
chemical structure image
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cortical surface area measurement
1
3
0
13.8
48.7
mathematical ability
2
1
2
20.4
intelligence
1
1
0
5.5
0.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cortical surface area measurement
0
13.8
48.7
mathematical ability
2
20.4
intelligence
0
5.5
0.3
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase kinase kinase 7
VGNC:7196
462888
Macaque
mitogen-activated protein kinase kinase kinase 7
703101
Mouse
MGI:1346877
26409
Rat
RGD:1309438
313121
Dog
mitogen-activated protein kinase kinase kinase 7
VGNC:42977
102156745
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase kinase kinase 7
Macaque
mitogen-activated protein kinase kinase kinase 7
Mouse
Rat
Dog
mitogen-activated protein kinase kinase kinase 7
Protein Structure (20 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O43318-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 20
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (166)
Activation of NF-kappaB in B cells (R-HSA-1169091)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 54
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NF-kappaB in B cells
Reactome
Adaptive Immune System
Reactome
Beta-catenin independent WNT signaling
Reactome
C-type lectin receptors (CLRs)
Reactome
CLEC7A (Dectin-1) signaling
Name
Explore in Pharos
Explore in Source
Activation of NF-kappaB in B cells
Adaptive Immune System
Beta-catenin independent WNT signaling
C-type lectin receptors (CLRs)
CLEC7A (Dectin-1) signaling
Gene Ontology Terms (38)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
WormBase
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (283)
1 – 10 of 283
TAB1
Tchem
Family: Kinase
Novelty: 0.00721424
p_int: 0.999999992
p_ni: 9e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
EMILIN1
Tbio
Novelty: 0.02550566
p_int: 0.999998764
p_ni: 0.000001236
Score: 0.168
Data Source: BioPlex,STRINGDB
SYNC
Tbio
Novelty: 0.04605223
p_int: 0.999998469
p_ni: 0.00000153
Data Source: BioPlex
CARNMT1
Tbio
Family: Enzyme
Novelty: 0.28121779
p_int: 0.999954894
p_ni: 0.000045106
Score: 0.152
Data Source: BioPlex,STRINGDB
AARSD1
Tdark
Novelty: 0.75372406
p_int: 0.999943975
p_ni: 0.000056025
Data Source: BioPlex
TH
Tclin
Family: Enzyme
Novelty: 0.00025719
p_int: 0.999518484
p_ni: 0.000481515
Score: 0.169
Data Source: BioPlex,STRINGDB
TGM2
Tchem
Family: Enzyme
Novelty: 0.0005293
p_int: 0.999236077
p_ni: 0.000763393
p_wrong: 5.3e-7
Data Source: BioPlex
PCDH20
Tbio
Novelty: 0.07862843
p_int: 0.996164796
p_ni: 0.003835202
p_wrong: 1e-9
Data Source: BioPlex
CCDC102B
Tdark
Novelty: 0.28075569
p_int: 0.99195838
p_ni: 0.008041598
p_wrong: 2.1e-8
Data Source: BioPlex
CARD8
Tbio
Family: Enzyme
Novelty: 0.0146799
p_int: 0.991420129
p_ni: 0.008579864
p_wrong: 7e-9
Score: 0.156
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  200.75

PubMed score by year
PubTator Score  351.31

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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