You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ARHGEF9
Rho guanine nucleotide exchange factor 9

Protein Summary
Description
Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters (By similarity). The protein encoded by this gene is a Rho-like GTPase that switches between the active (GTP-bound) state and inactive (GDP-bound) state to regulate CDC42 and other genes. This brain-specific protein also acts as an adaptor protein for the recruitment of gephyrin and together these proteins facilitate receceptor recruitement in GABAnergic and glycinergic synapses. Defects in this gene are the cause of startle disease with epilepsy (STHEE), also known as hyperekplexia with epilepsy, as well as several other types of cognitive disability. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253401
  • ENSP00000253401
  • ENSG00000131089
  • ENST00000623517
  • ENSP00000485369
  • ENST00000624843
  • ENSP00000485626

Symbol
  • ARHDH9
  • KIAA0424
  • PEM2
  • EIEE8
  • PEM-2
  • HPEM-2
  • COLLYBISTIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
cell type or tissue
0.84
virus perturbation
0.79
PubMedID
0.75
cell line
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.44   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 166   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.44   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (119)
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.994
Data Source:  STRINGDB
GPHN
Tbio
Novelty:  0.0020752
Score:  0.981
Data Source:  STRINGDB
RAC1
Tbio
Family:  Enzyme
Novelty:  0.00365325
Score:  0.977
Data Source:  STRINGDB
RAC3
Tbio
Family:  Enzyme
Novelty:  0.02125361
Score:  0.976
Data Source:  STRINGDB
RAC2
Tbio
Family:  Enzyme
Novelty:  0.00116234
Score:  0.975
Data Source:  STRINGDB
GABRG2
Tclin
Family:  IC
Novelty:  0.00819163
Score:  0.954
Data Source:  STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.949
Data Source:  STRINGDB
RHOD
Tbio
Family:  Enzyme
Novelty:  0.0029764
Score:  0.942
Data Source:  STRINGDB
RHOBTB1
Tbio
Novelty:  0.02152609
Score:  0.939
Data Source:  STRINGDB
RHOBTB2
Tbio
Novelty:  0.00734789
Score:  0.938
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Cell death signalling via NRAGE, NRIF and NADE (R-HSA-204998)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell death signalling via NRAGE, NRIF and NADE
Reactome
Death Receptor Signalling
Reactome
G alpha (12/13) signalling events
Reactome
GABA receptor activation
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Cell death signalling via NRAGE, NRIF and NADE
Death Receptor Signalling
G alpha (12/13) signalling events
GABA receptor activation
GPCR downstream signalling
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
74.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
74.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Cdc42 guanine nucleotide exchange factor 9
VGNC:6429
465666
Macaque
Cdc42 guanine nucleotide exchange factor 9
707387
Mouse
MGI:2442233
236915
Dog
Cdc42 guanine nucleotide exchange factor 9
VGNC:38092
100686228
Horse
Cdc42 guanine nucleotide exchange factor 9
VGNC:15497
100054217
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Cdc42 guanine nucleotide exchange factor 9
Macaque
Cdc42 guanine nucleotide exchange factor 9
Mouse
Dog
Cdc42 guanine nucleotide exchange factor 9
Horse
Cdc42 guanine nucleotide exchange factor 9
Publication Statistics
PubMed Score 78.44
PubMed score by year
PubTator Score 35.72
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title