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Tchem
ADCY6
Adenylate cyclase type 6

Protein Summary
Description
Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors (PubMed:17916776, PubMed:17110384). Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells (PubMed:17916776). Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion (By similarity). Signaling mediates cAMP-dependent activation of protein kinase PKA. This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility. May contribute to no ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307885
  • ENSP00000311405
  • ENSG00000174233
  • ENST00000357869
  • ENSP00000350536
  • ENST00000550422
  • ENSP00000446730

Symbol
  • KIAA0422
  • AC6
  • LCCS8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
molecular function
0.95
disease perturbation
0.79
pathway
0.75
small molecule perturbation
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 195.26   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 162   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 195.26   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 162   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
NKY80
chemical structure image
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
1
1
47.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
47.9
Pathways (111)
Activation of GABAB receptors (R-HSA-991365)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of GABAB receptors
Reactome
Adenylate cyclase activating pathway
Reactome
Adenylate cyclase inhibitory pathway
Reactome
Adrenaline,noradrenaline inhibits insulin secretion
Reactome
Aquaporin-mediated transport
Name
Explore in Pharos
Explore in Source
Activation of GABAB receptors
Adenylate cyclase activating pathway
Adenylate cyclase inhibitory pathway
Adrenaline,noradrenaline inhibits insulin secretion
Aquaporin-mediated transport
Gene Ontology Terms (24)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (483)
1 – 10 of 483
LGALS8
Tchem
Novelty: 0.00623836
p_int: 0.999994706
p_ni: 0.000005294
Data Source: BioPlex
NEUROG3
Tbio
Family: TF
Novelty: 0.00341077
p_int: 0.998263373
p_ni: 0.001736627
Data Source: BioPlex
B4GAT1
Tbio
Family: Enzyme
Novelty: 0.14959923
p_int: 0.99816879
p_ni: 0.00183121
Data Source: BioPlex
YIPF3
Tbio
Novelty: 0.12021667
p_int: 0.996853287
p_ni: 0.003146701
p_wrong: 1.2e-8
Data Source: BioPlex
ANKMY2
Tdark
Novelty: 0.50777631
p_int: 0.996465395
p_ni: 0.003534427
p_wrong: 1.78e-7
Score: 0.242
Data Source: BioPlex,STRINGDB
IPPK
Tbio
Family: Enzyme
Novelty: 0.02169701
p_int: 0.991189407
p_ni: 0.008810585
p_wrong: 7e-9
Data Source: BioPlex
SYNE4
Tbio
Novelty: 0.0739848
p_int: 0.989123375
p_ni: 0.010875609
p_wrong: 0.000001016
Data Source: BioPlex
ZNRF4
Tbio
Novelty: 0.16505328
p_int: 0.987830143
p_ni: 0.012169636
p_wrong: 2.21e-7
Data Source: BioPlex
LGALS3
Tchem
Novelty: 0.00032754
p_int: 0.981675538
p_ni: 0.01832413
p_wrong: 3.32e-7
Data Source: BioPlex
NKAIN1
Tdark
Family: Enzyme
Novelty: 0.52190272
p_int: 0.96807185
p_ni: 0.031924958
p_wrong: 0.000003191
Data Source: BioPlex
Publication Statistics
PubMed Score  195.26

PubMed score by year
PubTator Score  52.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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