You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CCP110
Centriolar coiled-coil protein of 110 kDa

Protein Summary
Description
Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545 PubMed:17681131, PubMed:23486064). Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (PubMed:16760425).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381396
  • ENSP00000370803
  • ENSG00000103540
  • ENST00000396208
  • ENSP00000379511
  • ENST00000396212
  • ENSP00000379515

Symbol
  • CEP110
  • CP110
  • KIAA0419
  • CP110
  • Cep110
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.96
transcription factor perturbation
0.91
virus perturbation
0.83
transcription factor
0.76
tissue sample
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.79   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.79   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (191)
SKAP1
Tbio
Family:  Enzyme
Novelty:  0.03753848
p_int:  0.994766709
p_ni:  0.005233291
Score:  0.173
Data Source:  BioPlex,STRINGDB
CDC16
Tbio
Novelty:  0.00916715
p_int:  0.983177897
p_ni:  0.016822103
Data Source:  BioPlex
MTUS2
Tbio
Novelty:  0.13504593
p_int:  0.933779847
p_ni:  0.066220153
Score:  0.232
Data Source:  BioPlex,STRINGDB
DISC1
Tbio
Novelty:  0.00183442
p_int:  0.892811338
p_ni:  0.107188662
Data Source:  BioPlex
CEP97
Tbio
Novelty:  0.12709162
Score:  0.997
Data Source:  STRINGDB
CEP290
Tbio
Novelty:  0.00526375
Score:  0.997
Data Source:  STRINGDB
PLK4
Tchem
Family:  Kinase
Novelty:  0.00265851
Score:  0.993
Data Source:  STRINGDB
CENPJ
Tbio
Novelty:  0.01337231
Score:  0.992
Data Source:  STRINGDB
CEP135
Tbio
Novelty:  0.03507768
Score:  0.991
Data Source:  STRINGDB
CEP76
Tdark
Novelty:  0.3880387
Score:  0.991
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (23)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
centriolar coiled coil protein 110
VGNC:5704
741286
Macaque
centriolar coiled-coil protein 110
694966
Mouse
MGI:2141942
101565
Rat
RGD:1310509
361634
Dog
centriolar coiled-coil protein 110
VGNC:38909
479826
Species
Name
OMA
EggNOG
Inparanoid
Chimp
centriolar coiled coil protein 110
Macaque
centriolar coiled-coil protein 110
Mouse
Rat
Dog
centriolar coiled-coil protein 110
Publication Statistics
PubMed Score 44.79
PubMed score by year
PubTator Score 28.96
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title